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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

24,251–24,300 of 31,435, by identifier

phylloquinol + [protein]-disulfide = phylloquinone + [protein]-dithiol
Right to leftBalance undeterminableRhea 57744
icosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)-methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H(+) = C32-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 NADP(+) + 5 CoA + 2 H2O
Direction not assertedBalance undeterminableRhea 57748
docosanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)-methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H(+) = C34-carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 NADP(+) + 5 CoA + 2 H2O
Direction not assertedBalance undeterminableRhea 57752
17-(4-hydroxyphenyl)heptadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)-methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H(+) = C35-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 NADP(+) + 5 CoA + 2 H2O
Direction not assertedBalance undeterminableRhea 57756
19-(4-hydroxyphenyl)nonadecanoyl-[(phenol)carboxyphthiodiolenone synthase] + 2 (S)-methylmalonyl-CoA + 3 malonyl-CoA + 5 NADPH + 10 H(+) = C37-(phenol)carboxyphthiodiolenone-[(phenol)carboxyphthiodiolenone synthase] + 5 CO2 + 5 NADP(+) + 5 CoA + 2 H2O
Direction not asserted

Balance undeterminable

Rhea 57760

2,6-dinitrotoluene + NADH + O2 = 3-methyl-4-nitrocatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57764

2-nitrotoluene + NADH + O2 = 3-methylcatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57768

3-nitrotoluene + NADH + O2 = 4-methylcatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57772

2-chloro-6-nitrotoluene + NADH + O2 = 4-chloro-3-methylcatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57776

2-chloro-4-nitrotoluene + NADH + O2 = 3-chloro-4-methylcatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57780

1,4-dinitrobenzene + NADH + O2 = 4-nitrocatechol + nitrite + NAD(+) + H(+)

Direction not assertedBalancedRhea 57784

1,3-dinitrobenzene + NADH + O2 = 4-nitrocatechol + nitrite + NAD(+) + H(+)

Direction not assertedBalancedRhea 57788

3,4-dinitrotoluene + NADH + O2 = 4-methyl-6-nitrocatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57792

4-nitrotoluene + NADH + O2 = 4-methylcatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57796

2,3-dinitrotoluene + NADH + O2 = 4-methyl-3-nitrocatechol + nitrite + NAD(+) + H(+)

Direction not assertedBalancedRhea 57800

1-chloro-3-nitrobenzene + NADH + O2 = 4-chlorocatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57804

1-chloro-3-nitrobenzene + NADH + O2 = 3-chlorocatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57808

1-chloro-2-nitrobenzene + NADH + O2 = 3-chlorocatechol + nitrite + NAD(+)

Direction not assertedBalancedRhea 57812

dGMP + H2O = 2-deoxy-D-ribose 5-phosphate + guanine

Direction not assertedBalancedRhea 57816

[phosphate](n) + ADP = [phosphate](n+1) + AMP

Direction not assertedBalance undeterminableRhea 57820

dAMP + H2O = 2-deoxy-D-ribose 5-phosphate + adenine

Direction not assertedBalancedRhea 57824

dIMP + H2O = 2-deoxy-D-ribose 5-phosphate + hypoxanthine

Direction not assertedBalancedRhea 57828

5-oxopentanoate + NADP(+) + H2O = glutarate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 57832

thermospermine + O2 + H2O = 3-aminopropanal + spermidine + H2O2

Direction not assertedBalancedRhea 57836

1D-myo-inositol 1,3-bisphosphate + H2O = 1D-myo-inositol 1-phosphate + phosphate

Direction not assertedBalancedRhea 57840

fraxetin + reduced [NADPH--hemoprotein reductase] + O2 = sideretin (reduced form) + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 57844

scopoletin + 2-oxoglutarate + O2 = fraxetin + succinate + CO2

Direction not assertedBalancedRhea 57848

a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = a pyrimidine nucleobase + 2-deoxy-D-ribose 5-phosphate

Direction not assertedBalance undeterminableRhea 57852

(E)-feruloyl-CoA + 2-oxoglutarate + O2 = (E)-6-hydroxyferuloyl-CoA + succinate + CO2

Direction not assertedBalancedRhea 57856

(E)-6-hydroxyferuloyl-CoA = scopoletin + CoA

Direction not assertedBalancedRhea 57860

indole-3-carbonyl nitrile + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxy-indole-3-carbonyl nitrile + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 57864

(E)-4-coumaroyl-CoA + 2-oxoglutarate + O2 = (E)-2,4-dihydroxycinnamoyl-CoA + succinate + CO2

Direction not assertedBalancedRhea 57868

(E)-2,4-dihydroxycinnamoyl-CoA = umbelliferone + CoA

Direction not assertedBalancedRhea 57872

uridine(54) in tRNA = pseudouridine(54) in tRNA

Left to rightBalancedRhea 57876

3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP + H(+)

Left to rightBalance undeterminableRhea 57880

Na(+)(in) + diphosphate + H2O = Na(+)(out) + 2 phosphate + H(+)

Direction not assertedBalancedTransportRhea 57884

a quinone + NADH + 5 H(+)(in) = a quinol + NAD(+) + 4 H(+)(out)

Direction not assertedBalance undeterminableTransportRhea 57888

a quinone + NADPH + 5 H(+)(in) = a quinol + NADP(+) + 4 H(+)(out)

Direction not assertedBalance undeterminableTransportRhea 57892

a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + 2-oxoglutarate + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + formaldehyde + succinate + CO2

Direction not assertedBalance undeterminableRhea 57896

N(6)-methyladenosine in U6 snRNA + 2-oxoglutarate + O2 = adenosine in U6 snRNA + formaldehyde + succinate + CO2

Direction not assertedBalancedRhea 57900

a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in U6 snRNA + 2-oxoglutarate + O2 = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in U6 snRNA + formaldehyde + succinate + CO2

Direction not assertedBalance undeterminableRhea 57904

L-glutamyl-tRNA(Gln) + ATP = 5-phosphooxy-L-glutamyl-tRNA(Gln) + ADP

Direction not assertedBalancedRhea 57908

5-phosphooxy-L-glutamyl-tRNA(Gln) + NH4(+) = L-glutaminyl-tRNA(Gln) + phosphate + H(+)

Direction not assertedBalancedRhea 57912

L-aspartyl-tRNA(Asn) + ATP = 4-phosphooxy-L-aspartyl-tRNA(Asn) + ADP + H(+)

Direction not assertedBalancedRhea 57916

4-phosphooxy-L-aspartyl-tRNA(Asn) + NH4(+) = L-asparaginyl-tRNA(Asn) + phosphate + H(+)

Direction not assertedBalancedRhea 57920

mutildienyl diphosphate + H2O = premutilin + diphosphate

Direction not assertedBalancedRhea 57924

beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + L-glutamine + ATP + H2O = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + L-glutamate + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 57928

beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + NH4(+) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + phosphate + H(+)

Direction not assertedBalancedRhea 57932

isopyridoxal + NAD(+) + H2O = 5-pyridoxate + NADH + 2 H(+)

Direction not assertedBalancedRhea 57936

Fe-coproporphyrin III + H2O2 + H(+) = harderoheme III + CO2 + 2 H2O

Direction not assertedBalancedRhea 57940

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