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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

24,101–24,150 of 31,435, by identifier

tyramine + L-ascorbate + O2 = (R)-octopamine + L-dehydroascorbate + H2O
Direction not assertedBalancedRhea 57132
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phosphoserine + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
Left to rightBalancedRhea 57136
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-N-(acetyl)-sphing-4-enine + 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine
Left to rightBalancedRhea 57140
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-octadecanoyl-N-(acetyl)-sphing-4-enine
Left to rightBalancedRhea 57144
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + N-(acetyl)-sphing-4-enine = 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine
Left to rightBalancedRhea 57148
L-lysyl-[protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-lysyl-[protein] + succinate + CO2

Left to rightBalance undeterminableRhea 57152

L-lysyl-[protein] + 2-oxoglutarate + O2 = 4-hydroxy-L-lysyl-[protein] + succinate + CO2

Direction not assertedBalance undeterminableRhea 57156

L-arginyl-[ribosomal protein eS6] + 2-oxoglutarate + O2 = (3R)-3-hydroxy-L-arginyl-[ribosomal protein eS6] + succinate + CO2

Direction not assertedBalance undeterminableRhea 57160

L-arginyl-[RCC1 domain-containing protein] + 2-oxoglutarate + O2 = (3R)-3-hydroxy-L-arginyl-[RCC1 domain-containing protein] + succinate + CO2

Direction not assertedBalance undeterminableRhea 57164

(R)-2-hydroxyglutarate + FAD + H(+) = FADH2 + 2-oxoglutarate

Direction not assertedBalancedRhea 57168

(S)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)

Right to leftBalancedRhea 57172

L-arginyl-[protein] + methylglyoxal = N(omega)-(1-hydroxy-2-oxopropyl)-L-arginyl-[protein]

Direction not assertedBalance undeterminableRhea 57176

methylglyoxal + L-lysyl-[protein] = N(6)-(1-hydroxy-2-oxopropyl)-L-lysyl-[protein]

Direction not assertedBalance undeterminableRhea 57180

methylglyoxal + L-cysteinyl-[protein] = S-(1-hydroxy-2-oxopropyl)-L-cysteinyl-[protein]

Direction not assertedBalance undeterminableRhea 57184

N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein] + H2O = L-arginyl-[protein] + glycolate + H(+)

Direction not assertedBalance undeterminableRhea 57188

N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein] + H2O = glycolate + L-lysyl-[protein] + H(+)

Direction not assertedBalance undeterminableRhea 57192

S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein] + H2O = glycolate + L-cysteinyl-[protein] + H(+)

Direction not assertedBalance undeterminableRhea 57196

glyoxal + L-arginyl-[protein] = N(omega)-(1-hydroxy-2-oxoethyl)-L-arginyl-[protein]

Direction not assertedBalance undeterminableRhea 57200

glyoxal + L-lysyl-[protein] = N(6)-(1-hydroxy-2-oxoethyl)-L-lysyl-[protein]

Direction not assertedBalance undeterminableRhea 57204

glyoxal + L-cysteinyl-[protein] = S-(1-hydroxy-2-oxoethyl)-L-cysteinyl-[protein]

Direction not assertedBalance undeterminableRhea 57208

dGTP + methylglyoxal = N(2)-(1-hydroxy-2-oxopropyl)-dGTP

Direction not assertedBalancedRhea 57212

glyoxal + dGTP = N(2)-(1-hydroxy-2-oxoethyl)-dGTP

Direction not assertedBalancedRhea 57216

methylglyoxal + GTP = N(2)-(1-hydroxy-2-oxopropyl)-GTP

Direction not assertedBalancedRhea 57220

glyoxal + GTP = N(2)-(1-hydroxy-2-oxoethyl)-GTP

Direction not assertedBalancedRhea 57224

glyoxal + GDP = N(2)-(1-hydroxy-2-oxoethyl)-GDP

Direction not assertedBalancedRhea 57228

methylglyoxal + GDP = N(2)-(1-hydroxy-2-oxopropyl)-GDP

Direction not assertedBalancedRhea 57232

methylglyoxal + GMP = N(2)-(1-hydroxy-2-oxopropyl)-GMP

Direction not assertedBalancedRhea 57236

glyoxal + GMP = N(2)-(1-hydroxy-2-oxoethyl)-GMP

Direction not assertedBalancedRhea 57240

N(2)-(1-hydroxy-2-oxopropyl)-dGTP + H2O = lactate + dGTP + H(+)

Direction not assertedBalancedRhea 57244

N(2)-(1-hydroxy-2-oxoethyl)-dGTP + H2O = dGTP + glycolate + H(+)

Direction not assertedBalancedRhea 57248

N(2)-(1-hydroxy-2-oxoethyl)-GTP + H2O = glycolate + GTP + H(+)

Direction not assertedBalancedRhea 57252

N(2)-(1-hydroxy-2-oxopropyl)-GTP + H2O = lactate + GTP + H(+)

Direction not assertedBalancedRhea 57256

N(2)-(1-hydroxy-2-oxopropyl)-GDP + H2O = lactate + GDP + H(+)

Direction not assertedBalancedRhea 57260

N(2)-(1-hydroxy-2-oxoethyl)-GDP + H2O = glycolate + GDP + H(+)

Direction not assertedBalancedRhea 57264

N(2)-(1-hydroxy-2-oxopropyl)-GMP + H2O = lactate + GMP + H(+)

Direction not assertedBalancedRhea 57268

a 2'-deoxyguanosine in DNA + methylglyoxal = an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA

Direction not assertedBalance undeterminableRhea 57272

a 2'-deoxyguanosine in DNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA

Direction not assertedBalance undeterminableRhea 57276

a guanosine in RNA + glyoxal = an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA

Direction not assertedBalance undeterminableRhea 57280

a guanosine in RNA + methylglyoxal = an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA

Direction not assertedBalance undeterminableRhea 57284

an N(2)-(1-hydroxy-2-oxopropyl)-guanosine in RNA + H2O = a guanosine in RNA + lactate + H(+)

Direction not assertedBalance undeterminableRhea 57288

an N(2)-(1-hydroxy-2-oxoethyl)-guanosine in RNA + H2O = a guanosine in RNA + glycolate + H(+)

Direction not assertedBalance undeterminableRhea 57292

an N(2)-(1-hydroxy-2-oxoethyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + glycolate + H(+)

Direction not assertedBalance undeterminableRhea 57296

an N(2)-(1-hydroxy-2-oxopropyl)-2'-deoxyguanosine in DNA + H2O = a 2'-deoxyguanosine in DNA + lactate + H(+)

Direction not assertedBalance undeterminableRhea 57300

N(2)-(1-hydroxy-2-oxoethyl)-GMP + H2O = glycolate + GMP + H(+)

Direction not assertedBalancedRhea 57304

N(5)-phospho-L-glutamine + CTP + H(+) = N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine + diphosphate

Direction not assertedBalancedRhea 57308

N(5)-(cytidine 5'-diphosphoramidyl)-L-glutamine + H2O = cytidine 5'-diphosphoramidate + L-glutamate + H(+)

Direction not assertedBalancedRhea 57312

cytidine 5'-diphosphoramidate + ATP = cytidine 3'-phospho-5'-diphosphoramidate + ADP + H(+)

Direction not assertedBalancedRhea 57316

N-terminal L-(Asp/Glu)3-[protein] + acetyl-CoA = N-terminal N-acetyl-L-(Asp/Glu)3-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 57320

N-terminal L-glutamyl-L-glutamyl-L-glutamyl-[protein] + acetyl-CoA = N-terminal N-acetyl-L-glutamyl-L-glutamyl-L-glutamyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 57324

N-terminal L-aspartyl-L-aspartyl-L-aspartyl-[protein] + acetyl-CoA = N-terminal N-acetyl-L-aspartyl-L-aspartyl-L-aspartyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 57328

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