Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

23,351–23,400 of 31,435, by identifier

(2E,6E,10E,14E)-geranylfarnesyl diphosphate = stellata-2,6,19-triene + diphosphate
Direction not assertedBalancedRhea 54076
5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-methionine = 5-methoxycarbonylmethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine
Direction not assertedBalancedRhea 54080
7-cyano-7-carbaguanosine(15) in tRNA + L-glutamine + H2O = archaeosine(15) in tRNA + L-glutamate
Direction not assertedBalancedRhea 54084
3,4-dihydroxyphenylacetate + NADH + O2 + H(+) = 2,4,5-trihydroxyphenylacetate + NAD(+) + H2O
Direction not assertedBalancedRhea 54088
3,4-dihydroxyphenylacetate + NADPH + O2 + H(+) = 2,4,5-trihydroxyphenylacetate + NADP(+) + H2O
Direction not assertedBalancedRhea 54092
N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N-terminal N-methyl-L-alanyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)
Left to rightBalance undeterminable

Rhea 54096

N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N-terminal N-methyl-L-prolyl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 54100

N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N-terminal N-methyl-L-seryl-L-prolyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 54104

(2E,6E)-farnesyl diphosphate = guaia-4,6-diene + diphosphate

Direction not assertedBalancedRhea 54108

(2E,6E)-farnesyl diphosphate = selina-4(15),7(11)-diene + diphosphate

Direction not assertedBalancedRhea 54112

(2E,6E,10E)-geranylgeranyl diphosphate = pseudolaratriene + diphosphate

Direction not assertedBalancedRhea 54116

coelenterazine h + O2 = coelenterazine h dioxetanone

Direction not assertedBalancedRhea 54120

coelenterazine h dioxetanone = excited coelenteramide h monoanion + CO2 + H(+)

Direction not assertedBalancedRhea 54124

3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 54128

a ribonucleoside 5'-diphosphate-alpha-D-glucose + D-glucose 6-phosphate = alpha,alpha-trehalose 6-phosphate + a ribonucleoside 5'-diphosphate + H(+)

Direction not assertedBalance undeterminableRhea 54132

cytidine(48) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(48) in tRNA precursor + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 54136

cytidine(49) in tRNA precursor + S-adenosyl-L-methionine = 5-methylcytidine(49) in tRNA precursor + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 54140

5-methylcytidine(34) in mitochondrial tRNA(Met) + 2 2-oxoglutarate + 2 O2 = 5-formylcytidine(34) in mitochondrial tRNA(Met) + 2 succinate + 2 CO2 + H2O

Direction not assertedBalancedRhea 54144

1,1'-dihydroxy-1,1',2,2'-tetrahydroneurosporene = 1-hydroxy-all-trans-1,2-dihydro-neurosporene + H2O

Direction not assertedBalancedRhea 54148

a uridine in rRNA + S-adenosyl-L-methionine = a 2'-O-methyluridine in rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 54152

[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2

Direction not assertedBalance undeterminableRhea 54156

[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2

Direction not assertedBalance undeterminableRhea 54160

N(6)-acyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]

Direction not assertedBalance undeterminableRhea 54172

a long-chain fatty aldehyde + holo-[ACP] + NADP(+) = a long-chain fatty acyl-[ACP] + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 54176

a long-chain fatty aldehyde + holo-[ACP] + NAD(+) = a long-chain fatty acyl-[ACP] + NADH + H(+)

Direction not assertedBalance undeterminableRhea 54180

an N-acyl-aromatic L-alpha-amino acid + H2O = an aromatic L-alpha-amino acid + a carboxylate

ReversibleBalance undeterminableRhea 54184

N-acetyl-L-phenylalanine + H2O = L-phenylalanine + acetate

Direction not assertedBalancedRhea 54188

L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)

Left to rightBalance undeterminableRhea 54192

N(6)-methyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 54196

N(6),N(6)-dimethyl-L-lysyl-[protein] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 54200

2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine

Left to rightBalancedRhea 54204

2-(prostaglandin G2)-sn-glycero-3-phosphoethanolamine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine + A + H2O

Left to rightBalancedRhea 54208

2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + 2 O2 = 2-(prostaglandin G2)-sn-glycero-3-phosphocholine

Left to rightBalancedRhea 54212

2-(prostaglandin G2)-sn-glycero-3-phosphocholine + AH2 = 2-(prostaglandin H2)-sn-glycero-3-phosphocholine + A + H2O

Left to rightBalancedRhea 54216

1-hydroxy-all-trans-1,2-dihydro-neurosporene = all-trans-neurosporene + H2O

Direction not assertedBalancedRhea 54220

2-(prostaglandin H2)-sn-glycero-3-phosphocholine = 2-(prostaglandin E2)-sn-glycero-3-phosphocholine

Direction not assertedBalancedRhea 54224

2-(prostaglandin H2)-sn-glycero-3-phosphoethanolamine = 2-(prostaglandin E2)-sn-glycero-3-phosphoethanolamine

Direction not assertedBalancedRhea 54228

1,2-dioctanoyl-sn-glycerol + CDP-choline = 1,2-dioctanoyl-sn-glycero-3-phosphocholine + CMP + H(+)

Left to rightBalancedRhea 54232

1,2-didecanoyl-sn-glycerol + CDP-choline = 1,2-didecanoyl-sn-glycero-3-phosphocholine + CMP + H(+)

Left to rightBalancedRhea 54236

CDP-choline + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)

Left to rightBalancedRhea 54240

1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-choline = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CMP + H(+)

Left to rightBalancedRhea 54244

CDP-ethanolamine + 1,2-di-(9Z-octadecenoyl)-sn-glycerol = 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)

Left to rightBalancedRhea 54248

1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)

Left to rightBalancedRhea 54252

L-histidyl-[protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[protein] + succinate + CO2

Left to rightBalance undeterminableRhea 54256

L-asparaginyl-[protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-asparaginyl-[protein] + succinate + CO2

Direction not assertedBalance undeterminableRhea 54260

L-histidyl-[ankyrin-repeat domain protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[ankyrin-repeat domain protein] + succinate + CO2

Direction not assertedBalance undeterminableRhea 54264

L-asparaginyl-[hypoxia-inducible factor alpha subunit] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-asparaginyl-[hypoxia-inducible factor alpha subunit] + succinate + CO2

Direction not assertedBalance undeterminableRhea 54268

L-asparaginyl-[ankyrin-repeat domain protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-asparaginyl-[ankyrin-repeat domain protein] + succinate + CO2

Direction not assertedBalance undeterminableRhea 54272

L-aspartyl-[protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-aspartyl-[protein] + succinate + CO2

Direction not assertedBalance undeterminableRhea 54276

L-aspartyl-[ankyrin-repeat domain protein] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-aspartyl-[ankyrin-repeat domain protein] + succinate + CO2

Direction not assertedBalance undeterminableRhea 54280

Page 468 of 629