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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

23,301–23,350 of 31,435, by identifier

a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)
Direction not assertedBalance undeterminableRhea 53876
ADP-alpha-D-glucose + D-glucose 6-phosphate = alpha,alpha-trehalose 6-phosphate + ADP + H(+)
Direction not assertedBalancedRhea 53880
CDP-alpha-D-glucose + D-glucose 6-phosphate = alpha,alpha-trehalose 6-phosphate + CDP + H(+)
Direction not assertedBalancedRhea 53884
TDP-alpha-D-glucose + D-glucose 6-phosphate = 5-methyl-UDP + alpha,alpha-trehalose 6-phosphate + H(+)
Direction not assertedBalancedRhea 53888
an S-polyprenyl-L-cysteine + O2 + H2O = a polyprenal + L-cysteine + H2O2
Left to rightBalance undeterminableRhea 53892
an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-D-GlcNAc derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-D-GlcNAc derivative + CMP + H(+)
Left to rightBalance undeterminable

Rhea 53896

L-threonyl-[myosin light chain] + ATP = O-phospho-L-threonyl-[myosin light chain] + ADP + H(+)

Left to rightBalance undeterminableRhea 53900

L-threonyl-[tau protein] + ATP = O-phospho-L-threonyl-[tau protein] + ADP + H(+)

Left to rightBalance undeterminableRhea 53904

(2E)-butenoyl-CoA + L-lysyl-[protein] = N(6)-(2E)-butenoyl-L-lysyl-[protein] + CoA + H(+)

Left to rightBalance undeterminableRhea 53908

butanoyl-CoA + L-lysyl-[protein] = N(6)-butanoyl-L-lysyl-[protein] + CoA + H(+)

Left to rightBalance undeterminableRhea 53912

an acyl-CoA + L-lysyl-[protein] = N(6)-acyl-L-lysyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 53916

L-threonyl-[Fas-activated protein] + ATP = O-phospho-L-threonyl-[Fas-activated protein] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 53920

a secondary amine + S-adenosyl-L-methionine = a methylated secondary amine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 53924

a tertiary amine + S-adenosyl-L-methionine = a methylated tertiary amine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 53928

prostaglandin I2 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-prostaglandin I2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 53932

thromboxane A2 + reduced [NADPH--hemoprotein reductase] + O2 = 19-hydroxy-thromboxane A2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 53936

thromboxane A2 + reduced [NADPH--hemoprotein reductase] + O2 = 18-hydroxy-thromboxane A2 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 53940

2-ethyl-4-hydroxy-5-methyl-3(2H)-furanone + NADP(+) = (2E)-2-ethylidene-4-hydroxy-5-methylfuran-3(2H)-one + NADPH + H(+)

Direction not assertedBalancedRhea 53944

holo-[BtrI ACP] + L-glutamate + ATP = gamma-L-glutamyl-[BtrI ACP] + ADP + phosphate

Direction not assertedBalance undeterminableRhea 53948

4-aminobutanoyl-[BtrI ACP] + L-glutamate + ATP = 4-(gamma-L-glutamylamino)butanoyl-[BtrI ACP] + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 53952

gamma-L-glutamyl-[BtrI ACP] + H(+) = 4-aminobutanoyl-[BtrI ACP] + CO2

Direction not assertedBalance undeterminableRhea 53956

4-(gamma-L-glutamylamino)butanoyl-[BtrI ACP] + FMNH2 + O2 = 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + FMN + H2O + H(+)

Direction not assertedBalance undeterminableRhea 53960

4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI ACP] + ribostamycin = gamma-L-glutamyl-butirosin B + holo-[BtrI ACP] + H(+)

Direction not assertedBalance undeterminableRhea 53964

apo-[BtrI ACP] + CoA = holo-[BtrI ACP] + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalance undeterminableRhea 53968

(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate

Left to rightBalancedRhea 53972

(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate

Left to rightBalancedRhea 53976

(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate

Left to rightBalancedRhea 53980

(11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate

Left to rightBalancedRhea 53984

O-phospho-L-threonyl-[myosin light chain] + H2O = L-threonyl-[myosin light chain] + phosphate

Direction not assertedBalance undeterminableRhea 53988

(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14R,15R)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate

Left to rightBalancedRhea 53992

(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H2O = (14S,15S)-dihydroxy-(5Z,8Z,11Z)-eicosatrienoate

Left to rightBalancedRhea 53996

(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11R,12R)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate

Left to rightBalancedRhea 54000

(11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H2O = (11S,12S)-dihydroxy-(5Z,8Z,14Z)-eicosatrienoate

Left to rightBalancedRhea 54004

(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8S,9S)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate

Direction not assertedBalancedRhea 54008

(8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate

Direction not assertedBalancedRhea 54012

(8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H2O = (8R,9R)-dihydroxy-(5Z,11Z,14Z)-eicosatrienoate

Left to rightBalancedRhea 54016

propanoyl-CoA + L-lysyl-[protein] = N(6)-propanoyl-L-lysyl-[protein] + CoA + H(+)

Left to rightBalance undeterminableRhea 54020

L-histidyl-[ribosomal protein uL15] + 2-oxoglutarate + O2 = (3S)-3-hydroxy-L-histidyl-[ribosomal protein uL15] + succinate + CO2

Direction not assertedBalance undeterminableRhea 54024

a 14alpha-methyl steroid + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = a Delta(14) steroid + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)

Left to rightBalance undeterminableRhea 54028

dTDP-4-amino-4,6-dideoxy-alpha-D-glucose + (6R)-10-formyltetrahydrofolate = dTDP-4-formamido-4,6-dideoxy-alpha-D-glucose + (6S)-5,6,7,8-tetrahydrofolate + H(+)

Direction not assertedBalancedRhea 54032

[mycoredoxin]-L-cysteine + arseno-mycothiol + H(+) = [mycoredoxin]-S-mycothiol-L-cysteine + arsenite

Direction not assertedBalance undeterminableRhea 54036

(2E,6E,10E)-geranylgeranyl diphosphate = (3E,7E)-dolathalia-3,7,11-triene + diphosphate

Direction not assertedBalancedRhea 54040

(2E,6E)-farnesyl diphosphate + H2O = 7-epi-alpha-eudesmol + diphosphate

Direction not assertedBalancedRhea 54044

(2E,6E)-farnesyl diphosphate + H2O = 4-epi-cubebol + diphosphate

Direction not assertedBalancedRhea 54048

(2E,6E)-farnesyl diphosphate + H2O = tau-cadinol + diphosphate

Direction not assertedBalancedRhea 54052

(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-hedycaryol + diphosphate

Direction not assertedBalancedRhea 54056

(2E,6E)-farnesyl diphosphate + H2O = (2Z,6E)-hedycaryol + diphosphate

Direction not assertedBalancedRhea 54060

(2E,6E)-farnesyl diphosphate + H2O = 10-epi-cubebol + diphosphate

Direction not assertedBalancedRhea 54064

(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = sesterfisherol + diphosphate

Direction not assertedBalancedRhea 54068

(2E)-geranyl diphosphate = beta-thujene + diphosphate

Direction not assertedBalancedRhea 54072

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