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Evidence

CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

22,801–22,850 of 31,435, by identifier

esculetin + (2E)-geranyl diphosphate = 8-geranylesculetin + diphosphate
Direction not assertedBalancedRhea 51864
umbelliferone + dimethylallyl diphosphate = demethylsuberosin + diphosphate
Direction not assertedBalancedRhea 51868
umbelliferone + dimethylallyl diphosphate = osthenol + diphosphate
Direction not assertedBalancedRhea 51872
2',4,4',6'-tetrahydroxychalcone + dimethylallyl diphosphate = desmethylxanthohumol + diphosphate
Direction not assertedBalancedRhea 51876
3,4,6-trichlorocatechol + O2 = (2Z,4E)-2,3,5-trichloromuconate + H(+)
Direction not assertedBalancedRhea 51880
L-proline betaine = D-proline betaine
Direction not assertedBalancedRhea 51884
2,3,5,6-tetrachlorohydroquinone + NAD(+) + H(+) = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH

Direction not assertedBalancedRhea 51888

N-acetylcadaverine + H2O = cadaverine + acetate

Direction not assertedBalancedRhea 51892

N(1)-acetylspermine + H2O = spermine + acetate

Direction not assertedBalancedRhea 51896

N(1)-acetylspermidine + H2O = spermidine + acetate

Direction not assertedBalancedRhea 51900

10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 51904

dATP + H2O = dADP + phosphate + H(+)

Left to rightBalancedRhea 51908

(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 51912

(2S)-2-amino-3-butenoate + H2O = 2-oxobutanoate + NH4(+)

Direction not assertedBalancedRhea 51916

a quinone + AH2 = a quinol + A

Direction not assertedBalance undeterminableRhea 51920

menaquinone-9 + AH2 = beta-dihydromenaquinone-9 + A

Direction not assertedBalancedRhea 51924

N-[(2S)-2-amino-2-carboxyethyl]-L-glutamate + NAD(+) + H2O = (S)-2,3-diaminopropanoate + 2-oxoglutarate + NADH + H(+)

Direction not assertedBalancedRhea 51928

2 Fe(III)-[cytochrome c3] + hydrogen sulfide + sulfite = 2 Fe(II)-[cytochrome c3] + thiosulfate

Direction not assertedBalance undeterminableRhea 51932

2-(glutathione-S-yl)-hydroquinone + glutathione = hydroquinone + glutathione disulfide

Direction not assertedBalancedRhea 51936

(1E,2S)-2-methylbutanal oxime = (1Z,2S)-2-methylbutanal oxime

Direction not assertedBalancedRhea 51940

8-amino-8-demethylriboflavin + 2 S-adenosyl-L-methionine = roseoflavin + 2 S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalancedRhea 51944

(2S)-2-methylbutanenitrile + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxy-2-methylbutanenitrile + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 51948

(E)-2-methylpropanal oxime + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxy-2-methylpropanenitrile + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 51952

(E)-2-methylpropanal oxime = (Z)-2-methylpropanal oxime

Direction not assertedBalancedRhea 51956

(Z)-2-methylpropanal oxime = 2-methylpropanenitrile + H2O

Direction not assertedBalancedRhea 51960

2-methylpropanenitrile + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxy-2-methylpropanenitrile + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 51964

(18R)-hydroxy-(5Z,8Z,11Z,14Z,16E)-eicosapentaenoate + O2 = (5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate

Left to rightBalancedRhea 51968

an L-polyhomomethionine + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = an (E)-omega-(methylsulfanyl)-alkanal oxime + 2 oxidized [NADPH--hemoprotein reductase] + CO2 + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 51972

an L-N-hydroxypolyhomomethionine + reduced [NADPH--hemoprotein reductase] + O2 = an L-N,N-dihydroxypolyhomomethionine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 51976

an L-N,N-dihydroxypolyhomomethionine + H(+) = an (E)-omega-(methylsulfanyl)-alkanal oxime + CO2 + H2O

Direction not assertedBalance undeterminableRhea 51980

all-trans-retinoate + reduced [NADPH--hemoprotein reductase] + O2 = all-trans-4-hydroxyretinoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 51984

(5S,6S)-epoxy-(18S)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = 18S-resolvin E1

Left to rightBalancedRhea 51988

an (E)-omega-(methylsulfanyl)-alkanal oxime + glutathione + reduced [NADPH--hemoprotein reductase] + O2 = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 51992

an (E)-omega-(methylsulfanyl)-alkanal oxime + reduced [NADPH--hemoprotein reductase] + O2 = a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 51996

a (1E)-1-aci-nitro-omega-(methylsulfanyl)alkane + glutathione = an S-[(1E)-1-(hydroxyimino)-omega-(methylsulfanyl)alkyl]-L-glutathione + H2O

Direction not assertedBalance undeterminableRhea 52000

methylglyoxal + NAD(+) + H2O = pyruvate + NADH + 2 H(+)

Direction not assertedBalancedRhea 52004

8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoate + ATP + CoA = 8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 52008

11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoate + ATP + CoA = 11,12-epoxy-(5Z,8Z,14Z)-eicosatrienoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 52012

14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate + ATP + CoA = 14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 52016

(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 = resolvin E2 + A + H2O

Direction not assertedBalancedRhea 52020

(5S)-hydroperoxy-(18S)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate + AH2 = 18S-resolvin E2 + A + H2O

Direction not assertedBalancedRhea 52024

a jasmonyl-L-amino acid + H2O = a jasmonate + an L-alpha-amino acid

Direction not assertedBalance undeterminableRhea 52028

L-isoleucine-(+)-7-isojasmonate + H2O = (+)-7-isojasmonate + L-isoleucine

Direction not assertedBalancedRhea 52032

L-isoleucine-(+)-12-hydroxy-7-isojasmonate + H2O = tuberonate + L-isoleucine

Direction not assertedBalancedRhea 52036

L-cystine = S-sulfanyl-L-cysteine + 2-aminoprop-2-enoate

Direction not assertedBalancedRhea 52040

mogrol + UDP-alpha-D-glucose = mogroside IE + UDP + H(+)

Direction not assertedBalancedRhea 52044

9-(9Z-octadecenoyloxy)-octadecanoate + H2O = 9-hydroxy-octadecanoate + (9Z)-octadecenoate + H(+)

Left to rightBalancedRhea 52048

9-hexadecanoyloxy-octadecanoate + H2O = 9-hydroxy-octadecanoate + hexadecanoate + H(+)

Left to rightBalancedRhea 52052

12-hexadecanoyloxy-octadecanoate + H2O = 12-hydroxyoctadecanoate + hexadecanoate + H(+)

Left to rightBalancedRhea 52056

12-(9Z-octadecenoyloxy)-octadecanoate + H2O = 12-hydroxyoctadecanoate + (9Z)-octadecenoate + H(+)

Left to rightBalancedRhea 52060

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