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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

22,401–22,450 of 31,435, by identifier

cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 25-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Left to rightBalance undeterminableRhea 50256
11(S)-hydroxy-14(S),15(S)-epoxy-(5Z,8Z,12E)-eicosatrienoate + glutathione = (11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoate
Left to rightBalancedRhea 50260
cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = 26-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Left to rightBalance undeterminableRhea 50264
(5S)-hydroperoxy-(18R)-hydroxy-(6E,8Z,11Z,14Z,16E)-eicosapentaenoate = (5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O
Left to rightBalancedRhea 50268
(5S,6S)-epoxy-(18R)-hydroxy-(7E,9E,11Z,14Z,16E)-eicosapentaenoate + H2O = resolvin E1
Left to rightBalancedRhea 50272
(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14R,15S)-epoxy-(5Z,8Z,10E)-eicosatrienoate
Left to right

Balanced

Rhea 50276

(14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (5S)-hydroperoxy-(14R,15S)-epoxy-(6E,8Z,11Z)-eicosatrienoate

Left to rightBalancedRhea 50280

(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (12S)-hydroperoxy-(14S,15R)-epoxy-(5Z,8Z,10E)-eicosatrienoate

Left to rightBalancedRhea 50284

(14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + O2 = (8S)-hydroperoxy-(14S,15R)-epoxy-(5Z,9E,11Z)-eicosatrienoate

Left to rightBalancedRhea 50288

all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-3,4-didehydroretinol + 2 oxidized [adrenodoxin] + 2 H2O

Left to rightBalance undeterminableRhea 50292

N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + reduced [NADPH--hemoprotein reductase] + O2 = 2-oxo-N-[(5Z,8Z,11Z,14Z)-eicosatetraenoyl]-serotonin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 50296

all-trans-retinol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = all-trans-4-hydroxyretinol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 50300

progesterone + reduced [NADPH--hemoprotein reductase] + O2 = 21-hydroxyprogesterone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 50304

17alpha-hydroxyprogesterone + reduced [NADPH--hemoprotein reductase] + O2 = 11-deoxycortisol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 50308

2-oxopentanoate + H(+) = butanal + CO2

Direction not assertedBalancedRhea 50312

ethyl octadecanoate + H2O = ethanol + octadecanoate + H(+)

Direction not assertedBalancedRhea 50316

1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[(9R,10S)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 50320

1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[(9S,10R)-epoxy-octadecanoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 50324

1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[8-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 50328

1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + reduced [NADPH--hemoprotein reductase] + O2 = 1-[11-hydroxy-(9Z)-octadecenoyl]-sn-glycero-3-phosphocholine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 50332

triacontanoate + reduced [NADPH--hemoprotein reductase] + O2 = omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 50336

testosterone + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 1alpha-hydroxytestosterone + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 50340

holo-[mycolipanoate synthase] + a long-chain fatty acyl-CoA + 3 (S)-methylmalonyl-CoA + 6 NADPH + 9 H(+) = long-chain mycolipanoyl-[mycolipanoate synthase] + 3 CO2 + 6 NADP(+) + 4 CoA + 3 H2O

Direction not assertedBalance undeterminableRhea 50344

a alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + L-asparaginyl-[protein] = N(4)-(alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)

Direction not assertedBalance undeterminableRhea 50348

a long-chain fatty acyl-[mycocerosate synthase] + 3 (R)-methylmalonyl-CoA + 6 NADPH + 9 H(+) = trimethylated-mycocerosoyl-[mycocerosate synthase] + 3 CO2 + 6 NADP(+) + 3 CoA + 3 H2O

Direction not assertedBalance undeterminableRhea 50352

4-hydroxy-6-methylpretetramide + NADPH + O2 = 4-dedimethylamino-4-oxo-anhydrotetracycline + NADP(+) + H2O

Direction not assertedBalancedRhea 50356

(R)-mandelonitrile + O2 = benzoyl cyanide + H2O2

Direction not assertedBalancedRhea 50360

(S)-scoulerine + reduced [NADPH--hemoprotein reductase] + O2 = (S)-nandinine + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 50364

2-methylbutan-2-ol + NADPH + O2 + H(+) = 3-hydroxy-3-methylbut-1-ene + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 50368

an N-acylsphingoid base 1-phosphate(in) = an N-acylsphingoid base 1-phosphate(out)

Direction not assertedBalance undeterminableTransportRhea 50372

a ceramide(in) + ATP + H2O = a ceramide(out) + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableTransportRhea 50376

3 malonyl-CoA + 3 H(+) = 1,3,5-trihydroxybenzene + 3 CO2 + 3 CoA

Direction not assertedBalancedRhea 50380

tetracycline + oxidized coenzyme F420-(gamma-L-Glu)(n) + H(+) = 5a,11a-dehydrotetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)

Direction not assertedBalance undeterminableRhea 50384

5a,11a-dehydrotetracycline + NADPH + O2 + H(+) = 5a,11a-dehydrooxytetracycline + NADP(+) + H2O

Direction not assertedBalancedRhea 50388

oxytetracycline + oxidized coenzyme F420-(gamma-L-Glu)(n) + H(+) = 5a,11a-dehydrooxytetracycline + reduced coenzyme F420-(gamma-L-Glu)(n)

Direction not assertedBalance undeterminableRhea 50392

(2-aminobenzoyl)acetate + octanoyl-CoA + H(+) = 2-heptyl-4(1H)-quinolone + CO2 + CoA + H2O

Direction not assertedBalancedRhea 50396

L-cysteinyl-[PqsC protein] + octanoyl-CoA = S-octanoyl-L-cysteinyl-[PqsC protein] + CoA

Direction not assertedBalance undeterminableRhea 50400

S-octanoyl-L-cysteinyl-[PqsC protein] + (2-aminobenzoyl)acetate + H(+) = L-cysteinyl-[PqsC protein] + 1-(2-aminophenyl)decane-1,3-dione + CO2

Direction not assertedBalance undeterminableRhea 50404

1-(2-aminophenyl)decane-1,3-dione = 2-heptyl-4(1H)-quinolone + H2O

Direction not assertedBalancedRhea 50408

N-terminal L-glutamyl-[protein] + L-leucyl-tRNA(Leu) = N-terminal L-leucyl-L-glutamyl-[protein] + tRNA(Leu) + H(+)

Direction not assertedBalance undeterminableRhea 50412

N-terminal L-arginyl-[protein] + L-leucyl-tRNA(Leu) = N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu) + H(+)

Direction not assertedBalance undeterminableRhea 50416

N-terminal L-aspartyl-[protein] + L-leucyl-tRNA(Leu) = N-terminal L-leucyl-L-aspartyl-[protein] + tRNA(Leu) + H(+)

Direction not assertedBalance undeterminableRhea 50420

(8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1

Left to rightBalancedRhea 50424

methanethiol + S-adenosyl-L-methionine = dimethyl sulfide + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 50428

prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O

Left to rightBalancedRhea 50432

prostaglandin H1 = prostaglandin E1

Direction not assertedBalancedRhea 50436

prostaglandin H1 = prostaglandin D1

Direction not assertedBalancedRhea 50440

(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 O2 = prostaglandin G3

Left to rightBalancedRhea 50444

prostaglandin G3 + AH2 = prostaglandin H3 + A + H2O

Left to rightBalancedRhea 50448

prostaglandin H3 = prostaglandin E3

Direction not assertedBalancedRhea 50452

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