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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

22,451–22,500 of 31,435, by identifier

prostaglandin H3 = prostaglandin D3
Direction not assertedBalancedRhea 50456
a medium-chain fatty acid + holo-[ACP] + ATP = a medium-chain fatty acyl-[ACP] + AMP + diphosphate
Direction not assertedBalance undeterminableRhea 50460
4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 8 malonyl-CoA + 16 NADPH + 24 H(+) = 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 16 NADP(+) + 8 CoA + 8 H2O
Direction not assertedBalance undeterminableRhea 50464
4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 9 malonyl-CoA + 18 NADPH + 27 H(+) = 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 18 NADP(+) + 9 CoA + 9 H2O
Direction not assertedBalance undeterminableRhea 50468
anthraniloyl-CoA + malonyl-CoA + H(+) = (2-aminobenzoyl)acetyl-CoA + CO2 + CoA
Direction not assertedBalancedRhea 50472
L-cysteinyl-[PqsD protein] + anthraniloyl-CoA = S-anthraniloyl-L-cysteinyl-[PqsD protein] + CoA
Direction not asserted

?

Balance undeterminable

Rhea 50476

N-terminal L-methionyl-L-aspartyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-aspartyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50480

N-terminal L-methionyl-L-asparaginyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-asparaginyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50484

N-terminal L-methionyl-L-glutamyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutamyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50488

N-terminal L-methionyl-L-glutaminyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-glutaminyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50492

N-terminal glycyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetylglycyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50496

N-terminal L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-alanyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50500

N-terminal L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50504

N-terminal L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-valyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50508

N-terminal L-cysteinyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-cysteinyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50512

N-terminal L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-threonyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50516

N-terminal L-methionyl-L-leucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-leucyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50520

N-terminal L-methionyl-L-isoleucyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-isoleucyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50524

N-terminal L-methionyl-L-phenylalanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-phenylalanyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50528

N-terminal L-methionyl-L-tyrosyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tyrosyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50532

prostaglandin E2 = prostaglandin A2 + H2O

Direction not assertedBalancedRhea 50536

prostaglandin A2 = prostaglandin C2

Direction not assertedBalancedRhea 50540

prostaglandin C2 = prostaglandin B2

Direction not assertedBalancedRhea 50544

prostaglandin E1 = prostaglandin A1 + H2O

Direction not assertedBalancedRhea 50548

prostaglandin C1 = prostaglandin B1

Direction not assertedBalancedRhea 50552

prostaglandin D2 = prostaglandin J2 + H2O

Direction not assertedBalancedRhea 50556

N-terminal L-methionyl-L-tryptophyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-tryptophyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50560

N-terminal L-methionyl-L-alanyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-alanyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50564

N-terminal L-methionyl-L-seryl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-seryl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50568

N-terminal L-methionyl-L-valyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-valyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50572

N-terminal L-methionyl-L-threonyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-threonyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50576

N-terminal L-methionyl-L-lysyl-[protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-L-lysyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50580

13,14-dihydro-15-oxo-prostaglandin E1 + NADP(+) = 15-oxoprostaglandin E1 + NADPH + H(+)

Right to leftBalancedRhea 50584

13,14-dihydro-15-oxo-PGF2alpha + NADP(+) = 15-oxoprostaglandin F2alpha + NADPH + H(+)

Right to leftBalancedRhea 50588

13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP(+) = 15-oxoprostaglandin F1alpha + NADPH + H(+)

Right to leftBalancedRhea 50592

N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50596

N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50600

N-terminal L-methionyl-[transmembrane protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50604

leukotriene B4 + NADP(+) = 12-oxo-leukotriene B4 + NADPH + H(+)

Left to rightBalancedRhea 50608

decanal + NADP(+) = (2E)-decenal + NADPH + H(+)

Right to leftBalancedRhea 50612

nonan-2-one + NADP(+) = (3E)-nonen-2-one + NADPH + H(+)

Right to leftBalancedRhea 50616

N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-galactose = alpha-D-Gal-(1->3)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl diphosphate + UDP + H(+)

Direction not assertedBalancedRhea 50620

an omega-(methylsulfanyl)-2-oxoalkanoate + acetyl-CoA + H2O = a 2-(omega-methylsulfanyl)alkylmalate + CoA + H(+)

Direction not assertedBalance undeterminableRhea 50624

a 2-(omega-methylsulfanyl)alkylmalate = a 3-(omega-methylsulfanyl)alkylmalate

Direction not assertedBalance undeterminableRhea 50628

a 2-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O

Direction not assertedBalance undeterminableRhea 50632

a 3-(omega-methylsulfanyl)alkylmalate = a 2-(omega-methylsulfanyl)alkylmaleate + H2O

Direction not assertedBalance undeterminableRhea 50636

2-(2-methylsulfanyl)ethylmalate = 3-(2-methylsulfanyl)ethylmalate

Direction not assertedBalancedRhea 50640

2-(3-methylsulfanyl)propylmalate = 3-(3-methylsulfanyl)propylmalate

Direction not assertedBalancedRhea 50644

2-(2-methylsulfanyl)ethylmalate = 2-(2-methylsulfanyl)ethylmaleate + H2O

Direction not assertedBalancedRhea 50648

2-(3-methylsulfanyl)propylmalate = 2-(2-methylsulfanyl)propylmaleate + H2O

Direction not assertedBalancedRhea 50652

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