Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

22,001–22,050 of 31,435, by identifier

9-ribosyl-trans-zeatin 5'-phosphate + H2O = trans-zeatin + D-ribose 5-phosphate
Direction not assertedBalancedRhea 48564
3-chlorocatechol + O2 = (2E,4Z)-2-chloromuconate + 2 H(+)
Direction not assertedBalancedRhea 48568
3,5-dichlorocatechol + O2 = (2E,4E)-2,4-dichloromuconate + 2 H(+)
Direction not assertedBalancedRhea 48572
4-chlorocatechol + O2 = 3-chloro-cis,cis-muconate + 2 H(+)
Direction not assertedBalancedRhea 48576
[pyruvate, water dikinase]-phosphate + phosphate + H(+) = [pyruvate, water dikinase] + diphosphate
Direction not assertedBalance undeterminableRhea 48580
2 leukotriene A4 + O2 + 2 H2O = 2 lipoxin A4
Left to rightBalancedRhea 48584
2 leukotriene A4 + O2 + 2 H2O = 2 lipoxin B4

Left to rightBalancedRhea 48588

a quinone + formate + H(+) = a quinol + CO2

Direction not assertedBalance undeterminableRhea 48592

1,2-didecanoylglycerol + H2O = decanoylglycerol + decanoate + H(+)

Left to rightBalancedRhea 48596

[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + UMP + H(+)

Direction not assertedBalance undeterminableRhea 48600

2,3-dihydroxybenzoyl-5'-AMP + holo-[ACP] = 2,3-dihydroxybenzoyl-[ACP] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 48604

a 2,3-saturated acyl-CoA + A = a 2,3-dehydroacyl-CoA + AH2

Direction not assertedBalance undeterminableRhea 48608

[molybdopterin-synthase sulfur-carrier protein]-C-terminal Gly-Gly-AMP + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + AH2 = [molybdopterin-synthase sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + L-cysteinyl-[cysteine desulfurase] + A + AMP + 2 H(+)

Direction not assertedBalance undeterminableRhea 48612

leukotriene D4 + H2O = leukotriene E4 + glycine

Left to rightBalancedRhea 48616

(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

Left to rightBalancedRhea 48620

(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Left to rightBalancedRhea 48624

a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 48628

(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = 5-oxo-(6E,8Z,11Z,14Z)-eicosatetraenoate + H2O

Left to rightBalancedRhea 48632

(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + H2O

Left to rightBalancedRhea 48636

(11R)-hydroxy-(5Z,8Z,12E,14Z)-eicosatetraenoate + NAD(+) = 11-oxo-(5Z,8Z,12E,14Z)-eicosatetraenoate + NADH + H(+)

Left to rightBalancedRhea 48640

prostaglandin H2 = (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde

Left to rightBalancedRhea 48644

lipoxin A4 + reduced [NADPH--hemoprotein reductase] + O2 = 20-hydroxy-lipoxin A4 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 48648

lipoxin B4 + reduced [NADPH--hemoprotein reductase] + O2 = 20-hydroxy-lipoxin B4 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 48652

5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 5,20-dihydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 48656

8-hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 8,20-dihydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 48660

12-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = 12,20-dihydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 48664

20-hydroxy-leukotriene B4 + reduced [NADPH--hemoprotein reductase] + O2 = 20-oxo-leukotriene B4 + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Left to rightBalance undeterminableRhea 48668

20-oxo-leukotriene B4 + reduced [NADPH--hemoprotein reductase] + O2 = 20-carboxy-leukotriene B4 + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Left to rightBalance undeterminableRhea 48672

6-trans-leukotriene B4 + reduced [NADPH--hemoprotein reductase] + O2 = 20-hydroxy-6-trans-leukotriene B4 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 48676

a very-long-chain (3R)-3-hydroxyacyl-CoA + NADP(+) = a very-long-chain 3-oxoacyl-CoA + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 48680

[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + H2O = [amino-group carrier protein]-C-terminal-L-glutamate + L-lysine

Direction not assertedBalance undeterminableRhea 48684

N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-meso-2,6-diaminoheptanedioyl-D-alanine + H2O = N-acetyl-D-glucosaminyl-N-acetylmuramoyl-L-alanyl-meso-2,6-diaminoheptanedioate + D-alanine

Direction not assertedBalancedRhea 48688

1,2-dioctanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = octanoyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + octanoate + H(+)

Left to rightBalancedRhea 48692

1,2-dioctanoyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = octanoyl-3-(beta-D-galactosyl)-sn-glycerol + octanoate + H(+)

Left to rightBalancedRhea 48696

long chain 1,2-diacyl-3-O-beta-D-galactosyl-sn-glycerol + H2O = long chain acyl-3-O-beta-D-galactosyl-sn-glycerol + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 48700

(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 = (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate

Left to rightBalancedRhea 48704

long chain 1,2-diacyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + H2O = long chain acyl-3-O-[alpha-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 48708

2 Fe(2+) + H2O2 + 2 H(+) = 2 Fe(3+) + 2 H2O

Direction not assertedBalancedRhea 48712

(13S)-hydroperoxy-(9Z,11E)-octadecadienoate = 13-oxo-(9Z,11E)-octadecadienoate + H2O

Left to rightBalancedRhea 48716

aurachin B + NAD(+) + H2O = 4-hydroxy-2-methyl-3-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH

Direction not assertedBalancedRhea 48720

aurachin B + H2O + H(+) = 3,4-dihydroxy-2-methyl-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide

Direction not assertedBalancedRhea 48724

3,4-dihydroxy-2-methyl-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NAD(+) = 4-hydroxy-2-methyl-3-oxo-4-[(2E,6E)-farnesyl]-3,4-dihydroquinoline 1-oxide + NADH + H(+)

Direction not assertedBalancedRhea 48728

[CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + H2O = [CysO sulfur-carrier protein]-C-terminal Gly-Gly + L-cysteine + H(+)

Direction not assertedBalance undeterminableRhea 48732

(5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 48736

[CysO sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + O-phospho-L-serine + H(+) = [CysO sulfur-carrier protein]-Gly-NH-CH2-C(O)-S-L-Cys + phosphate

Direction not assertedBalance undeterminableRhea 48740

(-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + succinate + CO2 + H2O

Direction not assertedBalancedRhea 48744

D-threitol + NAD(+) = D-erythrulose + NADH + H(+)

Direction not assertedBalancedRhea 48748

validamycin A + 2-oxoglutarate + O2 = validamycin B + succinate + CO2 + H(+)

Direction not assertedBalancedRhea 48752

erythritol + NAD(+) = D-erythrulose + NADH + H(+)

Direction not assertedBalancedRhea 48756

L-threitol + NAD(+) = L-erythrulose + NADH + H(+)

Direction not assertedBalancedRhea 48760

Page 441 of 629