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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

21,851–21,900 of 31,435, by identifier

(2E)-geranyl diphosphate + H2O = (2E)-geranyl phosphate + phosphate + H(+)
Left to rightBalancedRhea 47944
thiamine phosphate + H2O = thiamine + phosphate
Direction not assertedBalancedRhea 47948
[prokaryotic ubiquitin-like protein]-C-terminal-L-glutamine + H2O = [prokaryotic ubiquitin-like protein]-C-terminal-L-glutamate + NH4(+)
Direction not assertedBalance undeterminableRhea 47952
3-maleylpyruvate + H2O = maleate + pyruvate + H(+)
Direction not assertedBalancedRhea 47956
N(tele)-phospho-L-histidyl-[protein] + H2O = L-histidyl-[protein] + phosphate
Direction not assertedBalance undeterminableRhea 47960
N(pros)-phospho-L-histidyl-[protein] + H2O = L-histidyl-[protein] + phosphate
Direction not assertedBalance undeterminableRhea 47964
a ganglioside GM2 + H2O = a ganglioside GM3 + N-acetyl-beta-D-galactosamine

Left to rightBalance undeterminableRhea 47968

dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose + H2O

Direction not assertedBalancedRhea 47972

dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose + H2O

Direction not assertedBalancedRhea 47976

dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose = dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose

Direction not assertedBalancedRhea 47980

presqualene diphosphate + H2O = hydroxysqualene + diphosphate

Direction not assertedBalancedRhea 47984

2-dehydro-3-deoxy-L-galactonate + NAD(+) = 3-deoxy-D-glycero-2,5-hexodiulosonate + NADH + H(+)

Direction not assertedBalancedRhea 47988

NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)

Direction not assertedBalancedTransportRhea 47992

1,6-dihydro-beta-NAD + O2 + H(+) = H2O2 + NAD(+)

Direction not assertedBalancedRhea 47996

1,6-dihydro-beta-NADP + O2 + H(+) = H2O2 + NADP(+)

Direction not assertedBalancedRhea 48000

1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol + H2O2 = 3,4-dimethoxybenzaldehyde + guaiacol + glycolaldehyde + H2O

Direction not assertedBalancedRhea 48004

2-hydroxybenzoyl-CoA + NADH + O2 + H(+) = 2,5-dihydroxybenzoyl-CoA + NAD(+) + H2O

Direction not assertedBalancedRhea 48008

4-methyl-5-nitrocatechol + NADPH + O2 = 2-hydroxy-5-methylquinone + nitrite + NADP(+) + H2O + H(+)

Direction not assertedBalancedRhea 48012

4-methyl-5-nitrocatechol + NADH + O2 = 2-hydroxy-5-methylquinone + nitrite + NAD(+) + H2O + H(+)

Direction not assertedBalancedRhea 48016

a globoside Gb3Cer + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + D-galactose

Left to rightBalance undeterminableRhea 48020

1,2,3-tripropanoylglycerol + H2O = dipropanoylglycerol + propanoate + H(+)

Left to rightBalancedRhea 48024

triacetin + H2O = diacetylglycerol + acetate + H(+)

Direction not assertedBalancedRhea 48028

a globoside Gb4Cer (d18:1(4E)) + H2O = a globoside Gb3Cer (d18:1(4E)) + N-acetyl-beta-D-galactosamine

Direction not assertedBalance undeterminableRhea 48036

a globoside Gb4Cer + H2O = a globoside Gb3Cer + N-acetyl-beta-D-galactosamine

Direction not assertedBalance undeterminableRhea 48040

ganglioside GM1 (d18:1(4E)/18:0) + H2O = ganglioside GM2 (d18:1(4E)/18:0) + D-galactose

Direction not assertedBalancedRhea 48044

a ganglioside GM1 (d18:1(4E)) + H2O = a ganglioside GM2 (d18:1(4E)) + D-galactose

Direction not assertedBalance undeterminableRhea 48048

dermatan + n 3'-phosphoadenylyl sulfate = dermatan 4'-sulfate + n adenosine 3',5'-bisphosphate + n H(+)

Direction not assertedBalance undeterminableRhea 48052

a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + H2O = a beta-D-glucosylceramide + D-galactose

Direction not assertedBalance undeterminableRhea 48056

a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + D-galactose

Direction not assertedBalance undeterminableRhea 48060

a ganglioside GD1b (d18:1(4E)) + H2O = a ganglioside GM1 (d18:1(4E)) + N-acetylneuraminate

Left to rightBalance undeterminableRhea 48064

a ganglioside GM2 (d18:1(4E)) + H2O = a ganglioside GA2 (d18:1(4E)) + N-acetylneuraminate

Left to rightBalance undeterminableRhea 48068

a ganglioside GM1 (d18:1(4E)) + H2O = a ganglioside GA1 (d18:1(4E)) + N-acetylneuraminate

Left to rightBalance undeterminableRhea 48072

N,N-dimethyl-4-nitrosoaniline + a primary alcohol = 4-(hydroxylamino)-N,N-dimethylaniline + an aldehyde

Direction not assertedBalance undeterminableRhea 48076

abieta-8,11,13-triene + reduced [NADPH--hemoprotein reductase] + O2 = ferruginol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 48080

L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)

Left to rightBalance undeterminableRhea 48096

L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 48100

N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 48104

L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalance undeterminableRhea 48108

N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 48112

L-arginyl-[protein] + S-adenosyl-L-methionine = N(5)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 48116

a ganglioside GD3 + H2O = a ganglioside GM3 + N-acetylneuraminate

Left to rightBalance undeterminableRhea 48120

a ganglioside GD3 (d18:1(4E)) + H2O = a ganglioside GM3 (d18:1(4E)) + N-acetylneuraminate

Left to rightBalance undeterminableRhea 48124

(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesyl phosphate + phosphate + H(+)

Left to rightBalancedRhea 48128

(2E,6E)-farnesyl phosphate + H2O = (2E,6E)-farnesol + phosphate

Left to rightBalancedRhea 48132

a ganglioside GM3 + H2O = a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + N-acetylneuraminate

Left to rightBalance undeterminableRhea 48136

pheophorbide a + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = red chlorophyll catabolite + 2 oxidized [2Fe-2S]-[ferredoxin]

Direction not assertedBalance undeterminableRhea 48140

N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-(octadecanoyl)-sphing-4-enine + H2O = ganglioside GT1b (d18:1(4E)/18:0) + N-acetylneuraminate

Direction not assertedBalancedRhea 48144

ganglioside GT1b (d18:1(4E)/18:0) + H2O = ganglioside GD1b(d18:1(4E)/18:0) + N-acetylneuraminate

Direction not assertedBalancedRhea 48148

ganglioside GD1b(d18:1(4E)/18:0) + H2O = ganglioside GM1 (d18:1(4E)/18:0) + N-acetylneuraminate

Direction not assertedBalancedRhea 48152

a ganglioside GQ1b (d18:1(4E)) + H2O = a ganglioside GT1b (d18:1(4E)) + N-acetylneuraminate

Direction not assertedBalance undeterminableRhea 48156

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