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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

20,351–20,400 of 31,435, by identifier

(2E)-dodecenoyl-[ACP] + NADPH + H(+) = dodecanoyl-[ACP] + NADP(+)
Left to rightBalance undeterminableRhea 41880
dodecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxotetradecanoyl-[ACP] + holo-[ACP] + CO2
Left to rightBalance undeterminableRhea 41884
3-oxotetradecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxytetradecanoyl-[ACP] + NADP(+)
Left to rightBalance undeterminableRhea 41888
(3R)-hydroxytetradecanoyl-[ACP] = (2E)-tetradecenoyl-[ACP] + H2O
Left to rightBalance undeterminableRhea 41892
(2E)-tetradecenoyl-[ACP] + NADPH + H(+) = tetradecanoyl-[ACP] + NADP(+)
Left to rightBalance undeterminableRhea 41896
tetradecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxohexadecanoyl-[ACP] + holo-[ACP] + CO2
Left to rightBalance undeterminableRhea 41900
3-oxohexadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyhexadecanoyl-[ACP] + NADP(+)

Left to rightBalance undeterminableRhea 41904

(3R)-hydroxyhexadecanoyl-[ACP] = (2E)-hexadecenoyl-[ACP] + H2O

Left to rightBalance undeterminableRhea 41908

(2E)-hexadecenoyl-[ACP] + NADPH + H(+) = hexadecanoyl-[ACP] + NADP(+)

Left to rightBalance undeterminableRhea 41912

hexadecanoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxooctadecanoyl-[ACP] + holo-[ACP] + CO2

Left to rightBalance undeterminableRhea 41916

3-oxooctadecanoyl-[ACP] + NADPH + H(+) = (3R)-hydroxyoctadecanoyl-[ACP] + NADP(+)

Left to rightBalance undeterminableRhea 41920

(3R)-hydroxyoctadecanoyl-[ACP] = (2E)-octadecenoyl-[ACP] + H2O

Left to rightBalance undeterminableRhea 41924

(2E)-octadecenoyl-[ACP] + NADPH + H(+) = octadecanoyl-[ACP] + NADP(+)

Left to rightBalance undeterminableRhea 41928

hexadecanoyl-[ACP] + H2O = hexadecanoate + holo-[ACP] + H(+)

Left to rightBalance undeterminableRhea 41932

a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP-alpha-D-galactose = a neolactoside IV(3)-beta-[Gal-beta-(1->3)-GlcNAc]-nLc4Cer(d18:1(4E)) + UDP + H(+)

Left to rightBalance undeterminableRhea 41936

[amino-group carrier protein]-C-terminal-L-glutamate + L-2-aminoadipate + ATP = [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 41940

[amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ATP = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + ADP

Direction not assertedBalance undeterminableRhea 41944

[amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + phosphate + NADP(+) = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-phosphooxy-5-oxopentan-1-yl)-L-glutamine + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 41948

[amino-group carrier protein]-C-terminal-gamma-(L-lysyl)-L-glutamate + 2-oxoglutarate = [amino-group carrier protein]-C-terminal-N-(1-carboxy-5-oxopentan-1-yl)-L-glutamine + L-glutamate

Direction not assertedBalance undeterminableRhea 41952

2',3'-cyclophospho-CMP + H2O = cytidine 2'-phosphate + H(+)

Direction not assertedBalancedRhea 41956

a ganglioside GA2 (d18:1(4E)) + UDP-alpha-D-galactose = a ganglioside GA1 (d18:1(4E)) + UDP + H(+)

Left to rightBalance undeterminableRhea 41960

butanoyl-CoA + O2 = (2E)-butenoyl-CoA + H2O2

Direction not assertedBalancedRhea 41964

a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1alpha (d18:1(4E)) + CMP + H(+)

Left to rightBalance undeterminableRhea 41968

a ganglioside GD1a (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1aalpha (d18:1(4E)) + CMP + H(+)

Left to rightBalance undeterminableRhea 41972

a ganglioside GT1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1balpha (d18:1(4E)) + CMP + H(+)

Left to rightBalance undeterminableRhea 41976

3alpha-hydroxy-5alpha-pregnan-20-one + NAD(+) = 5alpha-pregnane-3,20-dione + NADH + H(+)

Left to rightBalancedRhea 41980

propan-2-ol + NAD(+) = acetone + NADH + H(+)

Direction not assertedBalancedRhea 41984

3beta-hydroxy-5alpha-pregnane-20-one + NAD(+) = 5alpha-pregnane-3,20-dione + NADH + H(+)

Direction not assertedBalancedRhea 41988

17beta-hydroxy-5alpha-androstan-3-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)

Left to rightBalancedRhea 41992

a globoside Gb4Cer (d18:1(4E)) + UDP-alpha-D-galactose = a globoside GalGb4Cer (d18:1(4E)) + UDP + H(+)

Left to rightBalance undeterminableRhea 41996

a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + UDP-alpha-D-galactose = an isogloboside iGb3Cer (d18:1(4E)) + UDP + H(+)

Left to rightBalance undeterminableRhea 42000

5alpha-androstane-3alpha,17beta-diol + NAD(+) = 17beta-hydroxy-5alpha-androstan-3-one + NADH + H(+)

Right to leftBalancedRhea 42004

5alpha-pregnan-20beta-ol-3-one + NAD(+) = 5alpha-pregnane-3,20-dione + NADH + H(+)

Left to rightBalancedRhea 42008

cortisol + NAD(+) = 11beta,17alpha-dihydroxypregn-4-ene-3,20,21-trione + NADH + H(+)

Left to rightBalancedRhea 42012

cortisone + NAD(+) = 17alpha-hydroxypregn-4-en-3,11,20-trione-21-al + NADH + H(+)

Left to rightBalancedRhea 42016

11-dehydrocorticosterone + NAD(+) = pregn-4-ene-3,11,20,21-tetraone + NADH + H(+)

Left to rightBalancedRhea 42020

3beta,7beta-dihydroxy-5beta-cholan-24-oate + NAD(+) = 3beta-hydroxy-7-oxo-5beta-cholan-24-oate + NADH + H(+)

Left to rightBalancedRhea 42024

ursodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)

Left to rightBalancedRhea 42028

N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(36)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2

Left to rightBalance undeterminableRhea 42032

chenodeoxycholate + NAD(+) = 7-oxolithocholate + NADH + H(+)

Left to rightBalancedRhea 42036

a ganglioside GM1 (d18:1(4E)) + GDP-beta-L-fucose = a ganglioside Fuc-GM1 (d18:1(4E)) + GDP + H(+)

Left to rightBalance undeterminableRhea 42040

a globoside GalGb4Cer (d18:1(4E)) + GDP-beta-L-fucose = a globoside Globo-H (d18:1(4E)) + GDP + H(+)

Left to rightBalance undeterminableRhea 42044

3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 42048

9-cis-retinol + NAD(+) = 9-cis-retinal + NADH + H(+)

Left to rightBalancedRhea 42052

13-cis-retinol + NAD(+) = 13-cis-retinal + NADH + H(+)

Direction not assertedBalancedRhea 42056

11-cis-retinol + NAD(+) = 11-cis-retinal + NADH + H(+)

Direction not assertedBalancedRhea 42060

GTP + ATP = 2',3'-cGAMP + 2 diphosphate

Left to rightBalancedRhea 42064

(3R,5R)-clavulanate-9-aldehyde + NADPH + H(+) = clavulanate + NADP(+)

Direction not assertedBalancedRhea 42068

(4Z)-2-oxohept-4-enedioate + H2O = (4S)-4-hydroxy-2-oxoheptanedioate

Direction not assertedBalancedRhea 42072

2-hydroxyglutarate + acetyl-CoA = 2-hydroxyglutaryl-CoA + acetate

Direction not assertedBalancedRhea 42076

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