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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

18,451–18,500 of 31,435, by identifier

3,5,7-trioxododecanoyl-CoA = olivetolate + CoA + H(+)
Direction not assertedBalancedRhea 34123
olivetolate + (2E)-geranyl diphosphate = cannabigerolate + diphosphate
Direction not assertedBalancedRhea 34127
olivetolate + neryl diphosphate = cannabinerolate + diphosphate
Direction not assertedBalancedRhea 34131
cannabigerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2
Direction not assertedBalancedRhea 34135
Delta(9)-tetrahydrocannabinolate + H(+) = Delta(9)-tetrahydrocannabinol + CO2
Direction not assertedBalancedRhea 34139
cannabinerolate + O2 = Delta(9)-tetrahydrocannabinolate + H2O2
Direction not assertedBalancedRhea 34143
2-deoxy-L-scyllo-inosose + L-glutamine = 2-deoxy-scyllo-inosamine + 2-oxoglutaramate

Direction not assertedBalancedRhea 34147

3-amino-2,3-dideoxy-scyllo-inosose + L-glutamine = 2-deoxystreptamine + 2-oxoglutaramate

Direction not assertedBalancedRhea 34151

UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine + acetyl-CoA = UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altrose + CoA + H(+)

Direction not assertedBalancedRhea 34155

UDP-N-acetylbacillosamine + acetyl-CoA = UDP-N,N'-diacetylbacillosamine + CoA + H(+)

Direction not assertedBalancedRhea 34159

hydroquinone + O2 = (2E,4Z)-4-hydroxy-6-oxohexa-2,4-dienoate + H(+)

Direction not assertedBalancedRhea 34163

2,6-dihydroxypseudooxynicotine + H2O = 2,6-dihydroxypyridine + 4-(methylamino)butanoate + H(+)

Direction not assertedBalancedRhea 34167

L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O + H(+)

Direction not assertedBalancedRhea 34171

2-hydroxybenzoyl-CoA + malonyl-CoA = 4-hydroxycoumarin + CO2 + 2 CoA

Direction not assertedBalancedRhea 34175

mycophenolic acid O-acyl-beta-D-glucuronide + H2O = mycophenolate + D-glucuronate + H(+)

Left to rightBalancedRhea 34179

CDP-alpha-D-abequose + alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate = alpha-D-Abe-(1->3)-alpha-D-Man-(1->4)-alpha-L-Rha-(1->3)-alpha-D-Gal-di-trans,octa-cis-undecaprenyl diphosphate + CDP + H(+)

Direction not assertedBalancedRhea 34183

(2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + succinate + H(+)

Direction not assertedBalancedRhea 34187

(2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)

Direction not assertedBalancedRhea 34191

2 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + O2 + 2 H(+) = 2 aureusidin 6-O-beta-glucoside + 2 H2O

Direction not assertedBalancedRhea 34195

2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + O2 + H(+) = bracteatin 6-O-beta-glucoside + H2O

Direction not assertedBalancedRhea 34199

2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + O2 = aureusidin 6-O-beta-glucoside + H2O

Direction not assertedBalancedRhea 34203

3-O-alpha-D-glucosyl-L-rhamnose + phosphate = beta-D-glucose 1-phosphate + L-rhamnopyranose

Direction not assertedBalancedRhea 34207

ecgonine methyl ester + NADP(+) = ecgonone methyl ester + NADPH + H(+)

Direction not assertedBalancedRhea 34211

4-oxo-4-(pyridin-3-yl)butanal + NADP(+) + H2O = 4-oxo-4-(pyridin-3-yl)butanoate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 34215

(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + NAD(+) + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H(+)

Direction not assertedBalancedRhea 34219

6-hydroxypseudooxynicotine + A + H2O = 2,6-dihydroxypseudooxynicotine + AH2

Direction not assertedBalancedRhea 34223

5-nitrosalicylate + O2 = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite + H(+)

Direction not assertedBalancedRhea 34227

5-nitrosalicylate + O2 = 4-nitro-6-oxohepta-2,4-dienedioate + H(+)

Direction not assertedBalancedRhea 34231

4-nitro-6-oxohepta-2,4-dienedioate = 2-oxo-3-(5-oxofuran-2-ylidene)propanoate + nitrite

Direction not assertedBalancedRhea 34235

L-glutamate = 3-aminopentanedioate

Direction not assertedBalancedRhea 34239

Mo-molybdopterin + GTP + H(+) = Mo-molybdopterin guanine dinucleotide + diphosphate

Direction not assertedBalancedRhea 34243

1-deoxymethyl-sphinganine + NADP(+) = 1-deoxymethyl-3-dehydrosphinganine + NADPH + H(+)

Direction not assertedBalancedRhea 34247

1-deoxysphinganine + NADP(+) = 1-deoxy-3-dehydrosphinganine + NADPH + H(+)

Direction not assertedBalancedRhea 34251

sporulenol = (R)-tetraprenyl-beta-curcumene + H2O

Direction not assertedBalancedRhea 34255

(+)-larreatricin + AH2 + O2 = (+)-3'-hydroxylarreatricin + A + H2O

Direction not assertedBalancedRhea 34259

fumigaclavine A + dimethylallyl diphosphate = fumigaclavine C + diphosphate

Direction not assertedBalancedRhea 34263

fumigaclavine B + acetyl-CoA = fumigaclavine A + CoA

Direction not assertedBalancedRhea 34267

2-nitroimidazole + H2O = 1,3-dihydro-2H-imidazol-2-one + nitrite + H(+)

Direction not assertedBalancedRhea 34271

2-deoxy-scyllo-inosamine + S-adenosyl-L-methionine = 3-amino-2,3-dideoxy-scyllo-inosose + 5'-deoxyadenosine + L-methionine + H(+)

Direction not assertedBalancedRhea 34275

a di-trans,poly-cis-dolichol + NADP(+) = a di-trans,poly-cis-polyprenol + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 34279

2 L-tyrosine + O2 = 2 L-dopa

Direction not assertedBalancedRhea 34283

2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O

Left to rightBalancedRhea 34287

2',4,4',6'-tetrahydroxychalcone + UDP-alpha-D-glucose = 2',4,4',6'-tetrahydroxychalcone 4'-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 34291

2',3,4,4',6'-pentahydroxychalcone + UDP-alpha-D-glucose = 2',3,4,4',6'-pentahydroxychalcone 4'-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 34295

2'-deamino-2'-hydroxyneamine + 2-oxoglutarate = 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate

Direction not assertedBalancedRhea 34299

L-lysine = L-pipecolate + NH4(+)

Direction not assertedBalancedRhea 34303

4-nitrocatechol + NADPH + O2 = 2-hydroxy-1,4-benzoquinone + nitrite + NADP(+) + H2O

Direction not assertedBalancedRhea 34307

4-nitrocatechol + NADH + O2 = 2-hydroxy-1,4-benzoquinone + nitrite + NAD(+) + H2O

Direction not assertedBalancedRhea 34311

4-nitrophenol + NADPH + O2 + H(+) = 1,4-benzoquinone + nitrite + NADP(+) + H2O

Direction not assertedBalancedRhea 34327

indole-3-pyruvate + NADPH + O2 + H(+) = (indol-3-yl)acetate + CO2 + NADP(+) + H2O

Direction not assertedBalancedRhea 34331

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