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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

18,301–18,350 of 31,435, by identifier

itraconazole(in) + ATP + H2O = itraconazole(out) + ADP + phosphate + H(+)
Direction not assertedBalancedTransportRhea 33503
sphing-4-enine 1-phosphate = (2E)-hexadecenal + phosphoethanolamine
Left to rightBalancedRhea 33507
2 5,6-dihydroxyindole + O2 = 2 indole-5,6-quinone + 2 H2O
Direction not assertedBalancedRhea 33515
sphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O
Direction not assertedBalance undeterminableRhea 33519
ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + H2O = ergosta-5,7,22,24(28)-tetraen-3beta-ol + acetate + H(+)
Direction not assertedBalancedRhea 33523
ergosta-5,7,22,24(28)-tetraen-3beta-ol + acetyl-CoA = ergosta-5,7,22,24(28)-tetraen-3beta-yl acetate + CoA
Direction not assertedBalancedRhea 33527

lanosteryl ester + H2O = lanosterol + a carboxylate + H(+)

Direction not assertedBalance undeterminableRhea 33535

ergosteryl ester + H2O = ergosterol + a carboxylate + H(+)

Direction not assertedBalance undeterminableRhea 33539

ergosteryl hexadecanoate + H2O = ergosterol + hexadecanoate + H(+)

Direction not assertedBalancedRhea 33543

lanosteryl hexadecanoate + H2O = lanosterol + hexadecanoate + H(+)

Direction not assertedBalancedRhea 33547

an N-acylsphinganine + H2O = sphinganine + a fatty acid

Left to rightBalance undeterminableRhea 33551

an N-acyl-(4R)-4-hydroxysphinganine + H2O = (4R)-hydroxysphinganine + a fatty acid

Left to rightBalance undeterminableRhea 33555

sn-glycerol 3-phosphate + an acyl-CoA = a 2-acyl-sn-glycerol 3-phosphate + CoA

Direction not assertedBalance undeterminableRhea 33559

(4R)-hydroxysphinganine + ATP = (4R)-hydroxysphinganine 1-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 33563

ethanol + A = acetaldehyde + AH2

Direction not assertedBalancedRhea 33567

methanol + A = formaldehyde + AH2

Direction not assertedBalancedRhea 33571

an inositol-1-phosphophytoceramide + beta-D-mannose = a mannosylinositol-1-phosphophytoceramide + H2O

Direction not assertedBalance undeterminableRhea 33575

UDP-2-acetamido-2-deoxy-alpha-D-glucuronate + NAD(+) = UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + NADH + H(+)

Direction not assertedBalancedRhea 33579

UDP-2-acetamido-2-deoxy-alpha-D-ribo-hex-3-uluronate + L-glutamate = UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate + 2-oxoglutarate

Direction not assertedBalancedRhea 33583

UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate + acetyl-CoA = UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate + CoA + H(+)

Direction not assertedBalancedRhea 33587

tetracosanoyl-CoA + sphinganine = N-tetracosanoylsphinganine + CoA + H(+)

Left to rightBalancedRhea 33591

tetracosanoyl-CoA + (4R)-hydroxysphinganine = N-tetracosanoyl-(4R)-hydroxysphinganine + CoA + H(+)

Direction not assertedBalancedRhea 33595

N-hexacosanoylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = N-hexacosanoyl-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 33599

N-hexacosanoylsphinganine + NADPH + O2 + H(+) = N-(2-hydroxyhexacosanoyl)-sphinganine + NADP(+) + H2O

Direction not assertedBalancedRhea 33603

(9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 33607

methyl salicylate + H2O = salicylate + methanol + H(+)

Direction not assertedBalancedRhea 33611

octadecanoate + ATP + CoA = octadecanoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 33615

tetradecanoate + ATP + CoA = tetradecanoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 33619

dodecanoate + ATP + CoA = dodecanoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 33623

decanoate + ATP + CoA = decanoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 33627

octanoate + ATP + CoA = octanoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 33631

docosanoate + ATP + CoA = docosanoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 33635

tetracosanoate + ATP + CoA = tetracosanoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 33639

(9Z)-tetradecenoate + ATP + CoA = (9Z)-tetradecenoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 33643

(9Z)-hexadecenoate + ATP + CoA = (9Z)-hexadecenoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 33647

(9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 33651

(9Z)-octadecenoate(out) = (9Z)-octadecenoate(in)

Direction not assertedBalancedTransportRhea 33655

N-tetracosanoylsphinganine + NADPH + O2 + H(+) = N-(2-hydroxytetracosanoyl)-sphinganine + NADP(+) + H2O

Direction not assertedBalancedRhea 33659

N-hexacosanoyl-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 33663

N-tetracosanoyl-(4R)-hydroxysphinganine + NADPH + O2 + H(+) = N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) + H2O

Direction not assertedBalancedRhea 33667

an N-(2,3-dihydroxyhexacosanoyl)-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O = N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+)

Direction not assertedBalance undeterminableRhea 33671

N-(2,3-dihydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADP(+) + H2O = N-(2-hydroxytetracosanoyl)-(4R)-hydroxysphinganine + NADPH + O2 + H(+)

Direction not assertedBalancedRhea 33675

N-tetracosanoylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = N-tetracosanoyl-(4R)-hydroxysphinganine + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 33679

octadecanoyl-CoA + L-serine + H(+) = 3-oxoeicosasphinganine + CO2 + CoA

Left to rightBalancedRhea 33683

3'-N-debenzoyltaxol + benzoyl-CoA = paclitaxel + CoA + H(+)

Direction not assertedBalancedRhea 33687

2-(1-hydroxyethyl)thiamine diphosphate + 2-oxobutanoate = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + thiamine diphosphate

Direction not assertedBalancedRhea 33691

C20 sphinganine + NADP(+) = 3-oxoeicosasphinganine + NADPH + H(+)

Direction not assertedBalancedRhea 33695

C20 sphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (4R)-hydroxyeicosasphinganine + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 33699

(4R)-hydroxyeicosasphinganine + hexacosanoyl-CoA = N-hexacosanoyl-eicosan-(4R)-hydroxysphinganine + CoA + H(+)

Direction not assertedBalancedRhea 33703

L-threonine + ATP = O-phospho-L-threonine + ADP + H(+)

Direction not assertedBalancedRhea 33707

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