Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

18,251–18,300 of 31,435, by identifier

2-hydroxycyclohexan-1-one + NADPH + O2 = 6-oxohexanoate + NADP(+) + H2O
Direction not assertedBalancedRhea 33283
spermidine + A = 1-pyrroline + propane-1,3-diamine + AH2
Direction not assertedBalancedRhea 33287
L-pentahomomethionine + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = (E)-8-(methylsulfanyl)octanal oxime + 2 oxidized [NADPH--hemoprotein reductase] + CO2 + 3 H2O + 2 H(+)
Direction not assertedBalance undeterminableRhea 33291
L-hexahomomethionine + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = (E)-9-(methylsulfanyl)nonanal oxime + 2 oxidized [NADPH--hemoprotein reductase] + CO2 + 3 H2O + 2 H(+)
Direction not assertedBalance undeterminableRhea 33295
[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine
Direction not assertedBalance undeterminableRhea 33299
(2R)-2-O-(alpha-D-mannosyl)-glycerate(out) + N(pros)-phospho-L-histidyl-[protein] = (2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate(in) + L-histidyl-[protein]

? Direction not asserted

Balance undeterminable

Rhea 33307

hydroxylamine + 2 A + NH4(+) = N2 + 2 AH2 + H2O + H(+)

Direction not assertedBalancedRhea 33311

a 1-acyl-sn-glycero-3-phosphate + hexadecanoyl-CoA = 1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate + CoA

Left to rightBalance undeterminableRhea 33315

a 1-acyl-sn-glycero-3-phosphate + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phosphate + CoA

Direction not assertedBalance undeterminableRhea 33319

a 1-acyl-sn-glycero-3-phosphate + tetradecanoyl-CoA = a 1-acyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA

Direction not assertedBalance undeterminableRhea 33323

1,2-dioctadecanoyl-sn-glycero-3-phosphate + H2O = 1,2-dioctadecanoyl-sn-glycerol + phosphate

Left to rightBalancedRhea 33335

hexacosanoyl-CoA + (4R)-hydroxysphinganine = N-hexacosanoyl-(4R)-hydroxysphinganine + CoA + H(+)

Direction not assertedBalancedRhea 33339

glycine + O2 = 2-iminoacetate + H2O2

Direction not assertedBalancedRhea 33343

2-iminoacetate + H2O = glyoxylate + NH4(+)

Direction not assertedBalancedRhea 33347

hexacosanoyl-CoA + sphinganine = N-hexacosanoylsphinganine + CoA + H(+)

Left to rightBalancedRhea 33351

a 1-acyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = a 1-acyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA

Left to rightBalance undeterminableRhea 33359

D-mannitol(out) + N(pros)-phospho-L-histidyl-[protein] = D-mannitol 1-phosphate(in) + L-histidyl-[protein]

Direction not assertedBalance undeterminableRhea 33363

N(pros)-phospho-L-histidyl-[protein] + D-glucose(out) = D-glucose 6-phosphate(in) + L-histidyl-[protein]

Direction not assertedBalance undeterminableRhea 33367

alpha,alpha-trehalose(out) + N(pros)-phospho-L-histidyl-[protein] = alpha,alpha-trehalose 6-phosphate(in) + L-histidyl-[protein]

Direction not assertedBalance undeterminableRhea 33371

a 1-acylglycerone 3-phosphate + NADPH + H(+) = a 1-acyl-sn-glycero-3-phosphate + NADP(+)

Direction not assertedBalance undeterminableRhea 33375

4-hydroxyeicosasphinganine 1-phosphate + H2O = (4R)-hydroxyeicosasphinganine + phosphate

Direction not assertedBalancedRhea 33379

(S)-malate + UDP-N-acetyl-alpha-D-glucosamine = (S)-malyl N-acetyl-alpha-D-glucosaminide + UDP + H(+)

Direction not assertedBalancedRhea 33383

cadaverine + S-adenosyl 3-(methylsulfanyl)propylamine = aminopropylcadaverine + S-methyl-5'-thioadenosine + H(+)

Direction not assertedBalancedRhea 33387

C20 sphinganine 1-phosphate + H2O = C20 sphinganine + phosphate

Direction not assertedBalancedRhea 33391

N(epsilon)-(5'-guanylyl)-N(alpha)-acetyl-L-lysine methyl ester + H2O = N(alpha)-acetyl-L-lysine methyl ester + GMP

Direction not assertedBalancedRhea 33395

N-acetyl-beta-D-muramate(out) + N(pros)-phospho-L-histidyl-[protein] = N-acetyl-beta-D-muramate 6-phosphate(in) + L-histidyl-[protein]

Direction not assertedBalance undeterminableRhea 33399

L-threonine + ATP = L-threonyl-5'-AMP + diphosphate

Direction not assertedBalancedRhea 33403

glycine + ATP + H(+) = glycyl-5'-AMP + diphosphate

Direction not assertedBalancedRhea 33407

(S)-malyl N-acetyl-alpha-D-glucosaminide + H2O = (S)-malyl alpha-D-glucosaminide + acetate

Direction not assertedBalancedRhea 33411

bornane-2,6-dione + H2O = [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+)

Direction not assertedBalancedRhea 33415

[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + ATP + CoA = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 33419

N,N'-diacetylchitobiose(out) + N(pros)-phospho-L-histidyl-[protein] = diacetylchitobiose-6'-phosphate(in) + L-histidyl-[protein]

Direction not assertedBalance undeterminableRhea 33423

(S)-malyl alpha-D-glucosaminide + L-cysteine = bacillithiol + H2O

Direction not assertedBalancedRhea 33427

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate = (3E)-2-oxohex-3-enedioate

Direction not assertedBalancedRhea 33431

fecosterol = episterol

Direction not assertedBalancedRhea 33435

glyoxal + O2 + H2O = glyoxylate + H2O2 + H(+)

Direction not assertedBalancedRhea 33439

4beta-methylzymosterol-4alpha-carboxylate + NADP(+) = 3-dehydro-4-methylzymosterol + CO2 + NADPH

Left to rightBalancedRhea 33447

N(6),N(6)-dimethyl-L-lysyl-[protein] + A + H2O = N(6)-methyl-L-lysyl-[protein] + formaldehyde + AH2

Direction not assertedBalance undeterminableRhea 33451

4alpha-carboxyzymosterol + NADP(+) = zymosterone + CO2 + NADPH

Left to rightBalancedRhea 33455

zymosterone + NADPH + H(+) = zymosterol + NADP(+)

Left to rightBalancedRhea 33459

episterol + NADPH + O2 + H(+) = 5-dehydroepisterol + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 33463

5-dehydroepisterol + NADPH + O2 + H(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 33467

an N-acyl-(4R)-4-hydroxysphinganine + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = an N-acyl-(4R)-4-hydroxysphinganine-1-phosphoinositol + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 33471

an N-acylsphinganine + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = an N-acylsphinganine-(1D-myo-inositol) + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 33475

lanosterol + an acyl-CoA = lanosteryl ester + CoA

Direction not assertedBalance undeterminableRhea 33479

ergosterol + an acyl-CoA = ergosteryl ester + CoA

Direction not assertedBalance undeterminableRhea 33483

2-hydroxyhexacosanoyl-CoA + (4R)-hydroxysphinganine = N-(2-hydroxyhexacosanyl)-(4R)-hydroxysphinganine + CoA + H(+)

Direction not assertedBalancedRhea 33487

2-hydroxyhexacosanoyl-CoA + sphinganine = N-(2-hydroxyhexacosanoyl)-sphinganine + CoA + H(+)

Direction not assertedBalancedRhea 33491

sn-glycerol 1-phosphate + all-trans-heptaprenyl diphosphate = 3-heptaprenyl-sn-glycero-1-phosphate + diphosphate

Direction not assertedBalancedRhea 33495

prephenate + H(+) = 3-[(4R)-4-hydroxycyclohexa-1,5-dien-1-yl]-2-oxopropanoate + CO2

Direction not assertedBalancedRhea 33499

Page 366 of 629