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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Reactions
Reach

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Cell types
Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

18,201–18,250 of 31,435, by identifier

6-amino-6-deoxyfutalosine + H2O = dehypoxanthine futalosine + adenine
Direction not assertedBalancedRhea 33079
dehypoxanthine futalosine + S-adenosyl-L-methionine = cyclic dehypoxanthinylfutalosinate + 5'-deoxyadenosine + L-methionine + H(+)
Direction not assertedBalancedRhea 33083
cyclic dehypoxanthinylfutalosinate = 1,4-dihydroxy-6-naphthoate + dihydroxyacetone
Direction not assertedBalancedRhea 33087
1,4-dihydroxy-6-naphthoate + all-trans-octaprenyl diphosphate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate
Direction not assertedBalancedRhea 33091
chorismate + inosine + phosphoenolpyruvate = futalosine
Direction not assertedUnbalancedRhea 33095
spermine + acetyl-CoA = N(1)-acetylspermine + CoA + H(+)
Left to rightBalancedRhea 33099
(2E,6E)-farnesyl diphosphate = alpha-muurolene + diphosphate

Direction not assertedBalancedRhea 33103

(2E,6E)-farnesyl diphosphate = gamma-muurolene + diphosphate

Direction not assertedBalancedRhea 33107

(2E,6E)-farnesyl diphosphate = beta-copaene + diphosphate

Direction not assertedBalancedRhea 33111

malonate(in) = malonate(out)

Direction not assertedBalancedTransportRhea 33115

(2E,6E)-farnesyl diphosphate = (+)-sativene + diphosphate

Direction not assertedBalancedRhea 33119

all-trans-heptaprenyl diphosphate = (R)-tetraprenyl-beta-curcumene + diphosphate

Direction not assertedBalancedRhea 33123

salicin-6-phosphate + H2O = salicyl alcohol + beta-D-glucose 6-phosphate

Direction not assertedBalancedRhea 33127

tetrahydro-4-hydroxyphenylpyruvate + L-phenylalanine = tetrahydrotyrosine + 3-phenylpyruvate

Direction not assertedBalancedRhea 33131

malonate(in) + Na(+)(in) = malonate(out) + Na(+)(out)

Direction not assertedBalancedTransportRhea 33135

L-aspartate(in) + L-alanine(out) = L-aspartate(out) + L-alanine(in)

Direction not assertedBalancedTransportRhea 33139

galactitol(in) = galactitol(out)

Direction not assertedBalancedTransportRhea 33143

daunorubicin(in) + ATP + H2O = daunorubicin(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 33147

(R)-dihydrolipoamide + acetyl-CoA = (R)-S(6)-acetyldihydrolipoamide + CoA

Direction not assertedBalancedRhea 33151

a 1-acyl-sn-glycero-3-phosphate + H2O = a 1-acyl-sn-glycerol + phosphate

Left to rightBalance undeterminableRhea 33155

an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine + H2O = an N-acylethanolamine + a 1,2-diacyl-sn-glycero-3-phosphate + H(+)

Left to rightBalance undeterminableRhea 33159

beta-nicotinamide D-riboside(in) = beta-nicotinamide D-riboside(out)

Direction not assertedBalancedTransportRhea 33163

2 a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) = sn-glycero-3-phospho-1D-myo-inositol + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)

Direction not assertedBalance undeterminableRhea 33167

D-maltose(in) = D-maltose(out)

Direction not assertedBalancedTransportRhea 33171

4-hydroxyphenylacetate(in) = 4-hydroxyphenylacetate(out)

Direction not assertedBalancedTransportRhea 33175

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)

Left to rightBalance undeterminableRhea 33179

citrate(in) = citrate(out)

Left to rightBalancedTransportRhea 33183

1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA

Left to rightBalancedRhea 33187

a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

Left to rightBalance undeterminableRhea 33191

a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

Left to rightBalance undeterminableRhea 33195

butan-1-ol + NAD(+) = butanal + NADH + H(+)

Direction not assertedBalancedRhea 33199

1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

Left to rightBalance undeterminableRhea 33203

L-glutamate + ATP + NADPH + H(+) = L-glutamate 5-semialdehyde + ADP + phosphate + NADP(+)

Direction not assertedBalancedRhea 33207

all-trans-heptaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) = 2-demethylmenaquinol-7 + CO2 + diphosphate

Direction not assertedBalancedRhea 33211

3 isopentenyl diphosphate + (2E,6E,10E)-geranylgeranyl diphosphate = all-trans-heptaprenyl diphosphate + 3 diphosphate

Direction not assertedBalancedRhea 33215

ent-kaur-16-en-19-oate + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = gibberellin A12 + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)

Direction not assertedBalance undeterminableRhea 33219

2-oxobutanoate + NAD(+) + CoA = propanoyl-CoA + CO2 + NADH

Direction not assertedBalancedRhea 33223

(E)-4-coumarate + H(+) = 4-vinylphenol + CO2

Direction not assertedBalancedRhea 33227

heme b + H2O2 = heme d cis-diol

Direction not assertedBalancedRhea 33231

Mg-protoporphyrin IX 13-monomethyl ester + 3 NADPH + 3 O2 + 2 H(+) = 3,8-divinyl protochlorophyllide a + 3 NADP(+) + 5 H2O

Direction not assertedBalancedRhea 33235

L-threonine + NAD(+) = aminoacetone + CO2 + NADH

Direction not assertedBalancedRhea 33239

L-tetrahomomethionine + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = (E)-7-(methylsulfanyl)heptanal oxime + 2 oxidized [NADPH--hemoprotein reductase] + CO2 + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 33243

putrescine + O2 = 1-pyrroline + H2O2 + NH4(+)

Direction not assertedBalancedRhea 33247

2 sucrose = 6-kestotriose + beta-D-glucose

Direction not assertedBalancedRhea 33251

2-demethylmenaquinol-7 + S-adenosyl-L-methionine = menaquinol-7 + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 33255

4-aminoimidazole + 2 H2O + H(+) = N-formimidoylglycine + NH4(+)

Direction not assertedBalancedRhea 33259

L-phenylalanine + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = (E)-phenylacetaldehyde oxime + 2 oxidized [NADPH--hemoprotein reductase] + CO2 + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 33263

a triacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycerol + a fatty acid + H(+)

Direction not assertedBalance undeterminableRhea 33271

a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 33275

L-tryptophan + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = (E)-(indol-3-yl)acetaldehyde oxime + 2 oxidized [NADPH--hemoprotein reductase] + CO2 + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 33279

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