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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

17,901–17,950 of 31,435, by identifier

dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-galactose
Direction not assertedBalancedRhea 31835
dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-3-dehydro-6-deoxy-alpha-D-glucose
Direction not assertedBalancedRhea 31839
2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA = 2-oxepin-2(3H)-ylideneacetyl-CoA
Direction not assertedBalancedRhea 31843
(S)-2,3-epoxysqualene = shionone
Direction not assertedBalancedRhea 31847
(S)-2,3-epoxysqualene = parkeol
Direction not assertedBalancedRhea 31851
(S)-2,3-epoxysqualene = achilleol B
Direction not assertedBalancedRhea 31855
(S)-2,3-epoxysqualene = glutinol

? Direction not asserted

Balanced

Rhea 31859

(S)-2,3-epoxysqualene = friedelin

Direction not assertedBalancedRhea 31863

(S)-2,3-epoxysqualene = baccharis oxide

Direction not assertedBalancedRhea 31867

(S)-2,3-epoxysqualene = alpha-seco-amyrin

Direction not assertedBalancedRhea 31871

(S)-2,3-epoxysqualene = marneral

Direction not assertedBalancedRhea 31875

(S)-2,3-epoxysqualene = beta-seco-amyrin

Direction not assertedBalancedRhea 31879

(S)-2,3-epoxysqualene = delta-amyrin

Direction not assertedBalancedRhea 31883

(S)-2,3-epoxysqualene = tirucalla-7,24-dien-3beta-ol

Direction not assertedBalancedRhea 31887

2-hydroxy-1-phenyl-1-propanone + NADP(+) = 1-phenyl-1,2-propanedione + NADPH + H(+)

Direction not assertedBalancedRhea 31891

(2E,6E)-farnesyl diphosphate = alpha-humulene + diphosphate

Direction not assertedBalancedRhea 31895

indole + reduced [NADPH--hemoprotein reductase] + O2 = indolin-2-one + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 31899

(S)-norcoclaurine + S-adenosyl-L-methionine = (S)-coclaurine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 31907

beta-D-fructose 1,6-bisphosphate + methylglyoxal = 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + D-glyceraldehyde 3-phosphate

Direction not assertedBalancedRhea 31911

D-maltose + ATP = alpha-maltose 1-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 31915

indolin-2-one + reduced [NADPH--hemoprotein reductase] + O2 = 3-hydroxyindolin-2-one + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 31919

3-hydroxyindolin-2-one + reduced [NADPH--hemoprotein reductase] + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 31927

2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + reduced [NADPH--hemoprotein reductase] + O2 = DIBOA + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 31939

cholest-4-en-3-one + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = (25S)-3-oxocholest-4-en-26-ol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 31943

ent-isokaurene + reduced [NADPH--hemoprotein reductase] + O2 = ent-isokauren-2beta-ol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 31947

9beta-pimara-7,15-diene + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 9beta-pimara-7,15-dien-19-oate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)

Direction not assertedBalance undeterminableRhea 31951

9beta-pimara-7,15-diene + reduced [NADPH--hemoprotein reductase] + O2 = 9beta-pimara-7,15-dien-19-ol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 31955

9beta-pimara-7,15-dien-19-ol + reduced [NADPH--hemoprotein reductase] + O2 = 9beta-pimara-7,15-dien-19-al + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 31959

9beta-pimara-7,15-dien-19-al + reduced [NADPH--hemoprotein reductase] + O2 = 9beta-pimara-7,15-dien-19-oate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 31963

ent-cassa-12,15-diene + reduced [NADPH--hemoprotein reductase] + O2 = ent-11beta-hydroxycassa-12,15-diene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 31967

10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADPH + O2 + H(+) = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP(+) + H2O

Direction not assertedBalancedRhea 31971

taxusin + reduced [NADPH--hemoprotein reductase] + O2 = 7beta-hydroxytaxusin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 31975

trimethylamine + NADPH + O2 = trimethylamine N-oxide + NADP(+) + H2O

Left to rightBalancedRhea 31979

abieta-7,13-dien-18-ol + reduced [NADPH--hemoprotein reductase] + O2 = abieta-7,13-dien-18,18-diol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 31983

(S)-2,3-epoxysqualene = baruol

Direction not assertedBalancedRhea 31987

(2E,6E)-farnesyl diphosphate = sesquithujene + diphosphate

Direction not assertedBalancedRhea 31991

(2E,6E)-farnesyl diphosphate = 7-epi-sesquithujene + diphosphate

Direction not assertedBalancedRhea 31995

(2E,6E)-farnesyl diphosphate = bicyclogermacrene + diphosphate

Direction not assertedBalancedRhea 31999

(+)-copalyl diphosphate = isopimara-8(14),15-diene + diphosphate

Direction not assertedBalancedRhea 32003

9alpha-copalyl diphosphate = isopimara-8(14),15-diene + diphosphate

Direction not assertedBalancedRhea 32007

(2E,6E)-farnesyl diphosphate + H2O = (+)-T-muurolol + diphosphate

Direction not assertedBalancedRhea 32011

(2E,6E)-farnesyl diphosphate = (-)-delta-cadinene + diphosphate

Direction not assertedBalancedRhea 32015

(2E,6E)-farnesyl diphosphate = beta-cubebene + diphosphate

Direction not assertedBalancedRhea 32019

(2E,6E)-farnesyl diphosphate + H2O = avermitilol + diphosphate

Direction not assertedBalancedRhea 32023

(2E,6E)-farnesyl diphosphate = (-)-alpha-cuprenene + diphosphate

Direction not assertedBalancedRhea 32027

(2E,6E)-farnesyl diphosphate = gamma-curcumene + diphosphate

Direction not assertedBalancedRhea 32031

(1E,2Z)-3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate + H2O = 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + (2Z,4Z)-2-hydroxyhexa-2,4-dienoate + H(+)

Direction not assertedBalancedRhea 32035

P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H2O = AMP + ATP + 2 H(+)

Left to rightBalancedRhea 32039

P(1),P(6)-bis(5'-adenosyl) hexaphosphate + H2O = 2 ATP + 2 H(+)

Left to rightBalancedRhea 32043

P(1),P(6)-bis(5'-adenosyl) hexaphosphate + H2O = adenosine 5'-pentaphosphate + AMP + 2 H(+)

Direction not assertedBalancedRhea 32047

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