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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

17,701–17,750 of 31,435, by identifier

(S)-2,3-epoxysqualene = camelliol C
Direction not assertedBalancedRhea 31011
indole-3-carboxylate + H(+) = indole + CO2
Direction not assertedBalancedRhea 31015
all-trans-4,4'-diapolycopene + 4 AH2 + 4 O2 = all-trans-4,4'-diapolycopene-4,4'-dial + 4 A + 6 H2O
Direction not assertedBalancedRhea 31019
squalene = dammara-20,24-diene
Direction not assertedBalancedRhea 31023
2-trans-(+)-abscisate + UDP-alpha-D-glucose = beta-D-glucopyranosyl trans-(+)-abscisate + UDP
Direction not assertedBalancedRhea 31027
2-cis-(+)-abscisate + UDP-alpha-D-glucose = beta-D-glucopyranosyl cis-(+)-abscisate + UDP
Direction not assertedBalancedRhea 31031
arabidiol = (S)-2,3-epoxysqualene + H2O

? Direction not asserted

Balanced

Rhea 31035

dodecanoyl-CoA + FAD + H(+) = (2E)-dodecenoyl-CoA + FADH2

Direction not assertedBalancedRhea 31039

(S)-2-methyl-3-oxopropanoate + NAD(+) + H2O = methylmalonate + NADH + 2 H(+)

Direction not assertedBalancedRhea 31043

(S)-2-methyl-3-oxopropanoate + NAD(+) + CoA = propanoyl-CoA + CO2 + NADH

Direction not assertedBalancedRhea 31047

(3R)-beta-leucine + NAD(+) + H2O = 4-methyl-3-oxopentanoate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 31051

estrone 3-sulfate + H2O = estrone + sulfate + H(+)

Direction not assertedBalancedRhea 31055

imidazole-4-acetaldehyde + NAD(+) + H2O = imidazole-4-acetate + NADH + 2 H(+)

Direction not assertedBalancedRhea 31059

6-amino-2-oxohexanoate = Delta(1)-piperideine-2-carboxylate + H2O

Direction not assertedBalancedRhea 31067

(S)-2-methyl-3-oxopropanoate + L-alanine = (S)-3-amino-2-methylpropanoate + pyruvate

Direction not assertedBalancedRhea 31071

(3S)-3-hydroxydodecanoyl-CoA = (2E)-dodecenoyl-CoA + H2O

Right to leftBalancedRhea 31075

3-hydroxyisovaleryl-CoA = 3-methylbut-2-enoyl-CoA + H2O

Right to leftBalancedRhea 31079

N-acetyl-D-muramoyl-L-alanine + H2O = N-acetyl-D-muramate + L-alanine

Direction not assertedBalancedRhea 31083

octanoyl-CoA + acetyl-CoA = 3-oxodecanoyl-CoA + CoA

Right to leftBalancedRhea 31087

dodecanoyl-CoA + acetyl-CoA = 3-oxotetradecanoyl-CoA + CoA

Right to leftBalancedRhea 31091

7,8-dihydrofolate + NADP(+) = folate + NADPH + H(+)

Direction not assertedBalancedRhea 31103

3-phenylpyruvate + O2 = (2-hydroxyphenyl)acetate + CO2

Direction not assertedBalancedRhea 31107

butanoyl-CoA + acetyl-CoA = 3-oxohexanoyl-CoA + CoA

Right to leftBalancedRhea 31111

biotin + ATP + H(+) = biotinyl-5'-AMP + diphosphate

Direction not assertedBalancedRhea 31115

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA = (2E)-2-methylbut-2-enoyl-CoA + H2O

Right to leftBalancedRhea 31119

3-O-methylgallate + O2 = 2-oxo-2H-pyran-4,6-dicarboxylate + methanol + H(+)

Direction not assertedBalancedRhea 31127

N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-5,10-methenyltetrahydrofolate + H2O = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + 2 H(+)

Direction not assertedBalancedRhea 31131

5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + diphosphate = 5-amino-4-imidazolecarboxyamide + 5-phospho-alpha-D-ribose 1-diphosphate

Direction not assertedBalancedRhea 31135

(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = 3-hydroxy-3-methyl-2-oxobutanoate + NADPH + H(+)

Direction not assertedBalancedRhea 31139

(3S)-hydroxyhexanoyl-CoA + NAD(+) = 3-oxohexanoyl-CoA + NADH + H(+)

Left to rightBalancedRhea 31143

3,4-dihydroxyphenylethyleneglycol + NAD(+) = 3,4-dihydroxymandelaldehyde + NADH + H(+)

Direction not assertedBalancedRhea 31147

L-selenocystathionine + H2O = L-selenocysteine + 2-oxobutanoate + NH4(+)

Left to rightBalancedRhea 31151

(3R,5S)-1-pyrroline-3-hydroxy-5-carboxylate + NAD(+) + 2 H2O = (4S)-4-hydroxy-L-glutamate + NADH + H(+)

Direction not assertedBalancedRhea 31155

(3S)-hydroxyhexadecanoyl-CoA + NAD(+) = 3-oxohexadecanoyl-CoA + NADH + H(+)

ReversibleBalancedRhea 31159

(3S)-hydroxyhexadecanoyl-CoA = (2E)-hexadecenoyl-CoA + H2O

Right to leftBalancedRhea 31163

(3S)-hydroxytetradecanoyl-CoA + NAD(+) = 3-oxotetradecanoyl-CoA + NADH + H(+)

Left to rightBalancedRhea 31167

(3S)-hydroxytetradecanoyl-CoA = (2E)-tetradecenoyl-CoA + H2O

Right to leftBalancedRhea 31171

2-methylpropenoyl-CoA + H2O = (S)-3-hydroxyisobutanoyl-CoA

Left to rightBalancedRhea 31175

(3S)-3-hydroxydodecanoyl-CoA + NAD(+) = 3-oxododecanoyl-CoA + NADH + H(+)

Left to rightBalancedRhea 31179

decanoyl-CoA + acetyl-CoA = 3-oxododecanoyl-CoA + CoA

Right to leftBalancedRhea 31183

(3S)-hydroxydecanoyl-CoA + NAD(+) = 3-oxodecanoyl-CoA + NADH + H(+)

Left to rightBalancedRhea 31187

(3S)-hydroxydecanoyl-CoA = (2E)-decenoyl-CoA + H2O

Right to leftBalancedRhea 31191

(3S)-hydroxyoctanoyl-CoA + NAD(+) = 3-oxooctanoyl-CoA + NADH + H(+)

ReversibleBalancedRhea 31195

(3S)-hydroxyoctanoyl-CoA = (2E)-octenoyl-CoA + H2O

Right to leftBalancedRhea 31199

hexanoyl-CoA + acetyl-CoA = 3-oxooctanoyl-CoA + CoA

Right to leftBalancedRhea 31203

hexanoyl-CoA + FAD + H(+) = (2E)-hexenoyl-CoA + FADH2

Direction not assertedBalancedRhea 31207

L-selenomethionine + ATP + H2O = L-adenosylselenomethionine + phosphate + diphosphate

Direction not assertedBalancedRhea 31211

(5-hydroxyindol-3-yl)acetaldehyde + NAD(+) + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H(+)

Direction not assertedBalancedRhea 31215

5-hydroxykynurenamine + CO2 = 5-hydroxy-L-kynurenine + H(+)

Direction not assertedBalancedRhea 31219

cis-beta-D-glucosyl-2-hydroxycinnamate + H2O = cis-2-coumarate + beta-D-glucose

Direction not assertedBalancedRhea 31223

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