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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Interactions
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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

17,651–17,700 of 31,435, by identifier

L-pipecolate + NAD(+) = Delta(1)-piperideine-2-carboxylate + NADH + H(+)
Right to leftBalancedRhea 30807
beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinamide D-riboside + phosphate
Direction not assertedBalancedRhea 30815
allantoin + H2O = allantoate + H(+)
Direction not assertedBalancedRhea 30819
UDP-N-acetyl-alpha-D-glucosamine = UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose + H2O
Direction not assertedBalancedRhea 30823
UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose
Direction not assertedBalancedRhea 30827
UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose = UDP-2-acetamido-2,6-dideoxy-beta-L-lyxo-hex-4-ulose
Direction not assertedBalancedRhea 30831
UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + NADPH + H(+) = UDP-2-acetamido-2,6-dideoxy-beta-L-talose + NADP(+)

Direction not assertedBalancedRhea 30835

UDP-2-acetamido-2,6-dideoxy-beta-L-talose = UDP-N-acetyl-beta-L-fucosamine

Direction not assertedBalancedRhea 30839

N-formylmaleamate + H2O = maleamate + formate + H(+)

Direction not assertedBalancedRhea 30843

glutaryl-CoA + FAD + 2 H(+) = (2E)-butenoyl-CoA + FADH2 + CO2

Direction not assertedBalancedRhea 30847

beta-D-fructose 1-phosphate = D-glyceraldehyde + dihydroxyacetone phosphate

ReversibleBalancedRhea 30851

dammarenediol-II = (S)-2,3-epoxysqualene + H2O

Direction not assertedBalancedRhea 30855

dITP + H2O = dIDP + phosphate + H(+)

Direction not assertedBalancedRhea 30859

4-O-phospho-L-tyrosine + H2O = L-tyrosine + phosphate

Direction not assertedBalancedRhea 30863

indole-3-acetaldehyde + NAD(+) + H2O = (indol-3-yl)acetate + NADH + 2 H(+)

Direction not assertedBalancedRhea 30867

2-deoxy-D-ribose + ATP = 2-deoxy-D-ribose 5-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 30871

D-lysine + 2-oxoglutarate = 6-amino-2-oxohexanoate + D-glutamate

Direction not assertedBalancedRhea 30875

prop-2-ynal + NAD(+) + H2O = propynoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 30879

D-glucurono-3,6-lactone + NAD(+) + 2 H2O = D-glucarate + NADH + 3 H(+)

Direction not assertedBalancedRhea 30883

6-hydroxymethyl-7,8-dihydropterin + 4-aminobenzoate = 7,8-dihydropteroate + H2O

Direction not assertedBalancedRhea 30887

O-acetyl-L-serine + thiosulfate = S-sulfo-L-cysteine + acetate + H(+)

Direction not assertedBalancedRhea 30891

propane-1,3-diamine + O2 + H2O = 3-aminopropanal + H2O2 + NH4(+)

Direction not assertedBalancedRhea 30895

bis(beta-D-glucosyl) crocetin + UDP-alpha-D-glucose = beta-D-gentiobiosyl beta-D-glucosyl crocetin + UDP + H(+)

Direction not assertedBalancedRhea 30899

demethylspheroidene + S-adenosyl-L-methionine = spheroidene + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 30903

(S)-3-methyl-2-oxopentanoate + NAD(+) + CoA = (2S)-2-methylbutanoyl-CoA + CO2 + NADH

Direction not assertedBalancedRhea 30907

a sphingomyelin + H2O = sphing-4-enine-phosphocholine + a carboxylate

Direction not assertedBalance undeterminableRhea 30911

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + H2O = beta-D-glucosyl-(1<->1)-sphing-4-enine + a fatty acid

Left to rightBalance undeterminableRhea 30915

rhodopin + A = (3E)-3,4-didehydrorhodopin + AH2

Direction not assertedBalancedRhea 30919

ADP-alpha-D-glucose + (R)-glycerate = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + ADP + H(+)

Direction not assertedBalancedRhea 30923

2-O-(4-deoxy-beta-L-threo-hex-4-enopyranuronosyl)-alpha-L-rhamnose + H2O = 5-dehydro-4-deoxy-D-glucuronate + L-rhamnopyranose

Direction not assertedBalancedRhea 30927

O-acetyl-L-homoserine + L-cysteine = L,L-cystathionine + acetate + H(+)

Direction not assertedBalancedRhea 30931

nicotinate beta-D-ribonucleotide + H2O = beta-D-ribosylnicotinate + phosphate

Direction not assertedBalancedRhea 30935

dIDP + ATP = dITP + ADP

Direction not assertedBalancedRhea 30939

octanoyl-CoA + FAD + H(+) = (2E)-octenoyl-CoA + FADH2

Direction not assertedBalancedRhea 30943

(2E,6E)-farnesyl diphosphate + H2O = 10-epi-gamma-eudesmol + diphosphate

Direction not assertedBalancedRhea 30947

(2E,6E)-farnesyl diphosphate + H2O = alpha-eudesmol + diphosphate

Direction not assertedBalancedRhea 30951

9,9'-di-cis-zeta-carotene + 2 a quinone = 7,7',9,9'-tetra-cis-lycopene + 2 a quinol

Direction not assertedBalance undeterminableRhea 30955

9,9'-di-cis-zeta-carotene + a quinone = 7,9,9'-tri-cis-neurosporene + a quinol

Direction not assertedBalance undeterminableRhea 30959

7,9,9'-tri-cis-neurosporene + a quinone = 7,7',9,9'-tetra-cis-lycopene + a quinol

Direction not assertedBalance undeterminableRhea 30963

9,9',15-tri-cis-zeta-carotene = 9,9'-di-cis-zeta-carotene

Direction not assertedBalancedRhea 30967

7,7',9,9'-tetra-cis-lycopene = all-trans-lycopene

Direction not assertedBalancedRhea 30971

15-cis-phytoene + 5 A = all-trans-3,4-didehydrolycopene + 5 AH2

Direction not assertedBalancedRhea 30975

all-trans-lycopene + A = all-trans-3,4-didehydrolycopene + AH2

Direction not assertedBalancedRhea 30979

a 3-O-[beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-seryl-[protein] + H2O = beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + L-seryl-[protein]

Direction not assertedBalance undeterminableRhea 30983

(S)-2,3-epoxysqualene = (17Z)-protosta-17(20),24-dien-3beta-ol

Direction not assertedBalancedRhea 30987

beta-amyrin + reduced [NADPH--hemoprotein reductase] + O2 = 24-hydroxy-beta-amyrin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 30991

sophoradiol + reduced [NADPH--hemoprotein reductase] + O2 = soyasapogenol B + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 30995

(S)-2,3-epoxysqualene = cucurbitadienol

Direction not assertedBalancedRhea 30999

(S)-2,3-epoxysqualene = germanicol

Direction not assertedBalancedRhea 31003

(S)-2,3-epoxysqualene = beta-amyrin

Direction not assertedBalancedRhea 31007

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