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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

17,601–17,650 of 31,435, by identifier

15-cis-phytoene + 3 A = all-trans-neurosporene + 3 AH2
Direction not assertedBalancedRhea 30599
15-cis-phytoene + A = all-trans-phytofluene + AH2
Direction not assertedBalancedRhea 30603
all-trans-phytofluene + A = all-trans-zeta-carotene + AH2
Direction not assertedBalancedRhea 30607
all-trans-zeta-carotene + A = all-trans-neurosporene + AH2
Direction not assertedBalancedRhea 30611
15-cis-phytoene + 2 A = all-trans-zeta-carotene + 2 AH2
Direction not assertedBalancedRhea 30615
all-trans-zeta-carotene + 2 A = all-trans-lycopene + 2 AH2
Direction not assertedBalancedRhea 30619
all-trans-neurosporene + A = all-trans-lycopene + AH2

? Direction not asserted

Balanced

Rhea 30623

(2R)-2,3-dihydroxy-3-methylbutanoate + NAD(+) = (2S)-2-acetolactate + NADH + H(+)

Direction not assertedBalancedRhea 30627

alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-1-di-trans,octa-cis-undecaprenyl diphosphate + UDP-alpha-D-glucuronate = beta-D-GlcA-(1->2)-alpha-D-Man-(1->3)-beta-D-Glc-(1->4)-alpha-D-Glc-di-trans,octa-cis-undecaprenyl diphosphate + UDP + H(+)

Direction not assertedBalancedRhea 30631

an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)

Left to rightBalance undeterminableRhea 30635

(R)-glycerate + GDP-alpha-D-mannose = (2R)-2-O-(alpha-D-mannosyl)-glycerate + GDP + H(+)

Direction not assertedBalancedRhea 30639

S-methyl-5'-thioinosine + phosphate = 5-(methylsulfanyl)-alpha-D-ribose 1-phosphate + hypoxanthine

Direction not assertedBalancedRhea 30643

1D-myo-inositol 3-phosphate + CTP + H(+) = CDP-1L-myo-inositol + diphosphate

Direction not assertedBalancedRhea 30647

dUMP + ATP = dUDP + ADP

Direction not assertedBalancedRhea 30655

4-(phosphooxy)-L-threonine + H2O = 4-hydroxy-L-threonine + phosphate

Direction not assertedBalancedRhea 30659

3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole = hapalindole H

Direction not assertedBalancedRhea 30663

N,N'-diacetylchitobiose + H2O = 2 N-acetyl-D-glucosamine

Left to rightBalancedRhea 30671

tetrahymanol = squalene + H2O

Direction not assertedBalancedRhea 30675

D-cellobiose + H2O = beta-D-glucose + D-glucose

Left to rightBalancedRhea 30679

UDP-N-acetyl-alpha-D-glucosamine + H2O = aldehydo-N-acetyl-D-mannosamine + UDP + H(+)

Left to rightBalancedRhea 30683

(4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

Direction not assertedBalancedRhea 30687

methanol + H2O2 = formaldehyde + 2 H2O

Direction not assertedBalancedRhea 30691

3-aminopropanal + NAD(+) + H2O = beta-alanine + NADH + 2 H(+)

Direction not assertedBalancedRhea 30695

beta-alanine + 2-oxoglutarate = 3-oxopropanoate + L-glutamate

Direction not assertedBalancedRhea 30699

salicylate + H(+) = phenol + CO2

Direction not assertedBalancedRhea 30703

putrescine + pyruvate = 4-aminobutanal + L-alanine

Direction not assertedBalancedRhea 30707

(S)-linalool = beta-myrcene + H2O

Direction not assertedBalancedRhea 30711

(2E)-geraniol = (S)-linalool

Direction not assertedBalancedRhea 30715

propanoyl-CoA + acetyl-CoA = 2-methyl-3-oxobutanoyl-CoA + CoA

ReversibleBalancedRhea 30719

A + NH4(+) + 2 ADP + 2 phosphate + H(+) = hydroxylamine + AH2 + 2 ATP + H2O

Direction not assertedBalancedRhea 30723

dATP + pyruvate = dADP + phosphoenolpyruvate + H(+)

Direction not assertedBalancedRhea 30727

butanoyl-CoA + FAD + H(+) = (2E)-butenoyl-CoA + FADH2

Direction not assertedBalancedRhea 30731

1D-myo-inositol 4-phosphate + H2O = myo-inositol + phosphate

Left to rightBalancedRhea 30735

1D-myo-inositol 3-phosphate + H2O = myo-inositol + phosphate

Left to rightBalancedRhea 30739

beta-nicotinamide D-riboside + H2O = D-ribose + nicotinamide + H(+)

Direction not assertedBalancedRhea 30743

hexadecanoyl-CoA + FAD + H(+) = (2E)-hexadecenoyl-CoA + FADH2

Direction not assertedBalancedRhea 30747

hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 30751

carbamate + ATP = carbamoyl phosphate + ADP

Direction not assertedBalancedRhea 30755

5-methylcytosine + H2O + H(+) = thymine + NH4(+)

Direction not assertedBalancedRhea 30759

L-valine + NAD(+) + H2O = 3-methyl-2-oxobutanoate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 30763

D-glucurono-3,6-lactone + H2O = D-glucuronate + H(+)

Direction not assertedBalancedRhea 30767

guanosine + H2O = guanine + D-ribose

Direction not assertedBalancedRhea 30771

pyridoxamine + O2 + H2O = pyridoxal + H2O2 + NH4(+)

Direction not assertedBalancedRhea 30775

D-gluconate + FAD + H(+) = 2-dehydro-D-gluconate + FADH2

Direction not assertedBalancedRhea 30779

D-glyceraldehyde + NAD(+) + H2O = (R)-glycerate + NADH + 2 H(+)

Direction not assertedBalancedRhea 30783

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + L-tyrosine + H2O

Direction not assertedBalancedRhea 30787

dGTP + pyruvate = dGDP + phosphoenolpyruvate + H(+)

Direction not assertedBalancedRhea 30791

2-oxoadipate + NAD(+) + CoA = glutaryl-CoA + CO2 + NADH

Direction not assertedBalancedRhea 30795

(3S)-3-hydroxybutanoyl-CoA + NAD(+) = acetoacetyl-CoA + NADH + H(+)

ReversibleBalancedRhea 30799

4-aminobutanal + NADP(+) + H2O = 4-aminobutanoate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 30803

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