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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

17,501–17,550 of 31,435, by identifier

plastoquinone-9 + 15-cis-phytoene = 15,9'-di-cis-phytofluene + plastoquinol-9
Direction not assertedBalancedRhea 30191
plastoquinone-9 + 15,9'-di-cis-phytofluene = plastoquinol-9 + 9,9',15-tri-cis-zeta-carotene
Direction not assertedBalancedRhea 30195
cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized 2[4Fe-4S]-[ferredoxin] + 2 ADP + 2 phosphate = reduced 2[4Fe-4S]-[ferredoxin] + benzoyl-CoA + 2 ATP + 2 H2O
Direction not assertedBalance undeterminableRhea 30199
P(1),P(4)-bis(5'-guanosyl) tetraphosphate + H2O = 2 GDP + 2 H(+)
Direction not assertedBalancedRhea 30203
2 oxidized [amicyanin] + methylamine + H2O = 2 reduced [amicyanin] + formaldehyde + NH4(+) + 2 H(+)
Direction not assertedBalance undeterminableRhea 30207
nitrous oxide + 2 Fe(III)-[cytochrome c] + H2O = 2 nitric oxide + 2 Fe(II)-[cytochrome c] + 2 H(+)
Direction not assertedBalance undeterminable

Rhea 30211

a menaquinol + 2 nitric oxide = nitrous oxide + a menaquinone + H2O

Direction not assertedBalance undeterminableRhea 30215

dimethyl sulfoxide + NAD(+) + H2O = dimethyl sulfone + NADH + H(+)

Direction not assertedBalancedRhea 30219

hydrogen sulfide + 2 Fe(III)-[cytochrome c] = sulfur + 2 Fe(II)-[cytochrome c] + H(+)

Direction not assertedBalance undeterminableRhea 30223

2 Fe(III)-[cytochrome c2] + dimethyl sulfide + H2O = 2 Fe(II)-[cytochrome c2] + dimethyl sulfoxide + 2 H(+)

Direction not assertedBalance undeterminableRhea 30227

S-(2E,6E)-farnesyl-L-cysteine + O2 + H2O = (2E,6E)-farnesal + L-cysteine + H2O2

Left to rightBalancedRhea 30231

L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)

Direction not assertedBalancedRhea 30235

n a quinone + n hydrogen sulfide + n H(+) = polysulfur(n-2) + n a quinol

Direction not assertedBalance undeterminableRhea 30239

4 L-ascorbate + O2 = 4 monodehydro-L-ascorbate radical + 2 H2O

Direction not assertedBalancedRhea 30243

2 plastoquinone-9 + 4 hnu + 2 H2O = 2 plastoquinol-9 + O2

Direction not assertedBalance undeterminableRhea 30247

2 a ubiquinol + O2 + n H(+)(in) = 2 a ubiquinone + 2 H2O + n H(+)(out)

Direction not assertedBalance undeterminableTransportRhea 30251

2 a ubiquinol + O2 = 2 a ubiquinone + 2 H2O

Direction not assertedBalance undeterminableRhea 30255

2 a menaquinol + O2 + n H(+)(in) = 2 a menaquinone + 2 H2O(in) + n H(+)(out)

Direction not assertedBalance undeterminableTransportRhea 30259

2 L-ascorbate + H2O2 = 2 monodehydro-L-ascorbate radical + 2 H2O

Direction not assertedBalancedRhea 30263

2 monodehydro-L-ascorbate radical = L-dehydroascorbate + L-ascorbate

Direction not assertedBalancedRhea 30267

2 (3,4-dimethoxyphenyl)methanol + H2O2 = 2 (3,4-dimethoxyphenyl)methanol radical + 2 H2O

Direction not assertedBalancedRhea 30271

H2O2 + AH2 = A + 2 H2O

Left to rightBalancedRhea 30275

2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin] + NAD(+) = 2 reduced [2Fe-2S]-[ferredoxin] + NADH + 3 H(+)

Direction not assertedBalance undeterminableRhea 30279

(-)-trans-permethrin + H2O = (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate + H(+)

Direction not assertedBalancedRhea 30283

2 a plastoquinone + 15-cis-phytoene = 9,9',15-tri-cis-zeta-carotene + 2 a plastoquinol

Direction not assertedBalance undeterminableRhea 30287

(9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate

Direction not assertedBalancedRhea 30291

GTP + pyruvate = phosphoenolpyruvate + GDP + H(+)

Direction not assertedBalancedRhea 30295

a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2

Left to rightBalance undeterminableRhea 30299

(+)-(R)-germacrene A + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = germacra-1(10),4,11(13)-trien-12-oate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)

Direction not assertedBalance undeterminableRhea 30303

7-methylxanthine + NADPH + O2 + H(+) = xanthine + formaldehyde + NADP(+) + H2O

Direction not assertedBalancedRhea 30307

7-methylxanthine + NADH + O2 + H(+) = xanthine + formaldehyde + NAD(+) + H2O

Direction not assertedBalancedRhea 30311

1,7-dimethylxanthine + NADH + O2 + H(+) = 7-methylxanthine + formaldehyde + NAD(+) + H2O

Direction not assertedBalancedRhea 30315

theobromine + NADH + O2 + H(+) = 7-methylxanthine + formaldehyde + NAD(+) + H2O

Direction not assertedBalancedRhea 30319

all-trans-beta-carotene + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = beta-cryptoxanthin + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 30323

beta-cryptoxanthin + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = all-trans-zeaxanthin + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 30327

all-trans-beta-carotene + 4 reduced [2Fe-2S]-[ferredoxin] + 2 O2 + 4 H(+) = all-trans-zeaxanthin + 4 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 30331

CTP + H2O + H(+) = UTP + NH4(+)

Left to rightBalancedRhea 30335

L-tryptophan + H(+) = tryptamine + CO2

Direction not assertedBalancedRhea 30339

FAD + succinate + H(+) = fumarate + FADH2

Direction not assertedBalancedRhea 30343

IDP + ATP = ITP + ADP

Left to rightBalancedRhea 30347

pyrrole-2-carboxylate + NADH + O2 + H(+) = 5-hydroxypyrrole-2-carboxylate + NAD(+) + H2O

Direction not assertedBalancedRhea 30351

methane + a quinol + O2 = methanol + a quinone + H2O

Direction not assertedBalance undeterminableRhea 30355

chlorophyllide a + 2 NADPH + 2 O2 + 2 H(+) = chlorophyllide b + 2 NADP(+) + 3 H2O

Direction not assertedBalancedRhea 30359

fumonisin B1 + 2 H2O = (2S,3S,5R,10R,12S,14S,15R,16R)-2-amino-12,16-dimethylicosane-3,5,10,14,15-pentol + 2 tricarballylate + 2 H(+)

Direction not assertedBalancedRhea 30363

adenosylcob(III)alamin 5'-phosphate + H2O = adenosylcob(III)alamin + phosphate

Direction not assertedBalancedRhea 30367

(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone

Direction not assertedBalancedRhea 30371

(2E,6E)-farnesyl diphosphate = (+)-thujopsene + diphosphate

Direction not assertedBalancedRhea 30375

(2E,6E)-farnesyl diphosphate = (+)-beta-chamigrene + diphosphate

Direction not assertedBalancedRhea 30379

(2E,6E)-farnesyl diphosphate = (-)-7-epi-alpha-selinene + diphosphate

Direction not assertedBalancedRhea 30383

GDP-alpha-D-glucose + phosphate = alpha-D-glucose 1-phosphate + GDP + H(+)

Direction not assertedBalancedRhea 30387

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