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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

17,451–17,500 of 31,435, by identifier

2'-deoxyadenosine(in) + H(+)(in) = 2'-deoxyadenosine(out) + H(+)(out)
Direction not assertedBalancedTransportRhea 29979
cytidine(in) + H(+)(in) = cytidine(out) + H(+)(out)
Direction not assertedBalancedTransportRhea 29983
adenosine(in) + H(+)(in) = adenosine(out) + H(+)(out)
Direction not assertedBalancedTransportRhea 29987
L-lyxopyranose(in) + H(+)(in) = L-lyxopyranose(out) + H(+)(out)
Direction not assertedBalancedTransportRhea 29991
putrescine(out) + ATP + H2O = putrescine(in) + ADP + phosphate + H(+)
Left to rightBalancedTransportRhea 29995
spermidine(out) + ATP + H2O = spermidine(in) + ADP + phosphate + H(+)
Direction not assertedBalancedTransportRhea 29999
alpha-D-Gal-(1->6)-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP + H(+)

Direction not assertedBalancedRhea 30003

L-arabinose(out) + ATP + H2O = L-arabinose(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 30007

beta-D-galactose(out) + ATP + H2O = beta-D-galactose(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 30011

alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP-alpha-D-glucose = alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + UDP + H(+)

Direction not assertedBalancedRhea 30015

alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-[alpha-D-Gal-(1->6)]-alpha-D-Glc-(1->3)-[L-alpha-D-Hep-(1->7)]-4-O-PO3(2-)-L-alpha-D-Hep-(1->3)-4-O-PO3(2-)-L-alpha-D-Hep-(1->5)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->6)-lipid A + ADP-L-glycero-beta-D-manno-heptose = lipid A-core + ADP + H(+)

Direction not assertedBalancedRhea 30019

pyridoxal 5'-phosphate + L-alanine = pyridoxamine 5'-phosphate + pyruvate

Direction not assertedBalancedRhea 30023

D-glyceraldehyde + NADH + H(+) = glycerol + NAD(+)

Direction not assertedBalancedRhea 30027

(S)-muconolactone = cis,cis-muconate + H(+)

Direction not assertedBalancedRhea 30031

3,4-dihydroxybenzoate + NADH + O2 + 2 H(+) = benzene-1,2,4-triol + CO2 + NAD(+) + H2O

Direction not assertedBalancedRhea 30035

3,4-dihydroxybenzoate + NADPH + O2 + 2 H(+) = benzene-1,2,4-triol + CO2 + NADP(+) + H2O

Direction not assertedBalancedRhea 30039

fumarate + L-aspartate = iminosuccinate + succinate

Direction not assertedBalancedRhea 30043

chloroacetaldehyde + NAD(+) + H2O = chloroacetate + NADH + 2 H(+)

Direction not assertedBalancedRhea 30047

fluoroacetate + H2O = fluoride + glycolate + H(+)

Direction not assertedBalancedRhea 30051

L-allo-threonine + NADP(+) = (2S)-2-amino-3-oxobutanoate + NADPH + H(+)

Direction not assertedBalancedRhea 30055

(S)-dihydroorotate + fumarate = orotate + succinate

Direction not assertedBalancedRhea 30059

2-demethylmenaquinol-8 + S-adenosyl-L-methionine = menaquinol-8 + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 30063

betaine aldehyde + NADP(+) + H2O = glycine betaine + NADPH + 2 H(+)

Direction not assertedBalancedRhea 30067

butanoate + acetyl-CoA = butanoyl-CoA + acetate

Direction not assertedBalancedRhea 30071

CMP + H2O = cytosine + D-ribose 5-phosphate

Direction not assertedBalancedRhea 30075

crotonobetaine + ATP + CoA = crotonobetainyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 30079

4 Cu(+) + O2 + 4 H(+) = 4 Cu(2+) + 2 H2O

Left to rightBalancedRhea 30083

(S)-2-hydroxyglutarate + FAD + H(+) = FADH2 + 2-oxoglutarate

Direction not assertedBalancedRhea 30087

a ubiquinone + D-alanine + H2O = a ubiquinol + pyruvate + NH4(+)

Direction not assertedBalance undeterminableRhea 30091

a menaquinone + (S)-malate = a menaquinol + oxaloacetate

Direction not assertedBalance undeterminableRhea 30095

all-trans-octaprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) = 2-demethylmenaquinol-8 + CO2 + diphosphate

Direction not assertedBalancedRhea 30099

2,5-didehydro-D-gluconate + NADH + H(+) = 5-dehydro-D-gluconate + NAD(+)

Direction not assertedBalancedRhea 30103

D-serine + NADP(+) = 2-aminomalonate semialdehyde + NADPH + H(+)

Direction not assertedBalancedRhea 30107

Fe(III)-enterobactin + 3 H2O + H(+) = Fe(III)-[N-(2,3-dihydroxybenzoyl)-L-serine] + 2 N-(2,3-dihydroxybenzoyl)-L-serine

Direction not assertedBalancedRhea 30111

decanoyl-[ACP] + H2O = decanoate + holo-[ACP] + H(+)

Direction not assertedBalance undeterminableRhea 30115

dodecanoyl-[ACP] + H2O = dodecanoate + holo-[ACP] + H(+)

Direction not assertedBalance undeterminableRhea 30119

tetradecanoyl-[ACP] + H2O = tetradecanoate + holo-[ACP] + H(+)

Left to rightBalance undeterminableRhea 30123

octanoyl-[ACP] + H2O = octanoate + holo-[ACP] + H(+)

Direction not assertedBalance undeterminableRhea 30131

dodecanoyl-CoA + H2O = dodecanoate + CoA + H(+)

Left to rightBalancedRhea 30135

octadecanoyl-CoA + H2O = octadecanoate + CoA + H(+)

Left to rightBalancedRhea 30139

octanoyl-CoA + H2O = octanoate + CoA + H(+)

Left to rightBalancedRhea 30143

FADH2 + NAD(+) = FAD + NADH + 2 H(+)

Direction not assertedBalancedRhea 30147

FADH2 + NADP(+) = FAD + NADPH + 2 H(+)

Direction not assertedBalancedRhea 30151

2 Fe(3+) + FADH2 = 2 Fe(2+) + FAD + 3 H(+)

Direction not assertedBalancedRhea 30155

D-erythrose 4-phosphate + dihydroxyacetone phosphate = D-sedoheptulose 1,7-bisphosphate

Direction not assertedBalancedRhea 30167

hexadecanoyl-[ACP] + sn-glycerol 3-phosphate = 1-hexadecanoyl-sn-glycero-3-phosphate + holo-[ACP]

Direction not assertedBalance undeterminableRhea 30171

2 plastoquinone-9 + 15-cis-phytoene = 2 plastoquinol-9 + 9,9',15-tri-cis-zeta-carotene

Direction not assertedBalancedRhea 30175

oxidized 2[4Fe-4S]-[ferredoxin] + oxalate = reduced 2[4Fe-4S]-[ferredoxin] + 2 CO2

Direction not assertedBalance undeterminableRhea 30179

L-galactonate + NAD(+) = keto-D-tagaturonate + NADH + H(+)

Direction not assertedBalancedRhea 30183

(S)-dihydroorotate + a quinone = orotate + a quinol

Direction not assertedBalance undeterminableRhea 30187

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