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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

16,901–16,950 of 31,435, by identifier

GMP + H2O = guanosine + phosphate
Left to rightBalancedRhea 27714
IMP + H2O = inosine + phosphate
Left to rightBalancedRhea 27718
UDP-4-deoxy-4-formamido-beta-L-arabinose + di-trans,octa-cis-undecaprenyl phosphate = 4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + UDP
Direction not assertedBalancedRhea 27722
5-dehydro-4-deoxy-D-glucarate = 2-hydroxy-3-oxopropanoate + pyruvate
Direction not assertedBalancedRhea 27726
4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid A (E. coli) = beta-L-Ara4N-lipid A (E. coli) + di-trans,octa-cis-undecaprenyl phosphate
Direction not assertedBalancedRhea 27730
4-deoxy-4-formamido-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + H2O = 4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + formate
Direction not assertedBalanced

Rhea 27734

2'-deoxyguanosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + guanine

Direction not assertedBalancedRhea 27738

2'-deoxyadenosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + adenine

Direction not assertedBalancedRhea 27742

L-cysteine + H(+) = cysteamine + CO2

Direction not assertedBalancedRhea 27746

2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine

Direction not assertedBalancedRhea 27750

methylglyoxal + H2O = (R)-lactate + H(+)

Direction not assertedBalancedRhea 27754

(6S)-5,6,7,8-tetrahydrofolate + glycine + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+) + CO2 + NADH

Direction not assertedBalancedRhea 27758

CTP + H2O = CMP + diphosphate + H(+)

Left to rightBalancedRhea 27762

3-(all-trans-octaprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = 2-methoxy-6-(all-trans-octaprenyl)phenol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 27770

2-methoxy-6-(all-trans-octaprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = 5-methoxy-2-methyl-3-(all-trans-octaprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 27774

4-hydroxy-3-(all-trans-octaprenyl)benzoate + H(+) = 2-all-trans-octaprenylphenol + CO2

Direction not assertedBalancedRhea 27778

all-trans-octaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-octaprenyl)benzoate + diphosphate

Direction not assertedBalancedRhea 27782

2-oxoglutarate + NAD(+) + CoA = succinyl-CoA + CO2 + NADH

Direction not assertedBalancedRhea 27786

2-all-trans-octaprenylphenol + NADPH + O2 + H(+) = 3-(all-trans-octaprenyl)benzene-1,2-diol + NADP(+) + H2O

Direction not assertedBalancedRhea 27790

4 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-heptaprenyl diphosphate + 4 diphosphate

Direction not assertedBalancedRhea 27794

5 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-octaprenyl diphosphate + 5 diphosphate

Direction not assertedBalancedRhea 27798

7 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-decaprenyl diphosphate + 7 diphosphate

Left to rightBalancedRhea 27802

acetoacetate + acetyl-CoA = acetoacetyl-CoA + acetate

Direction not assertedBalancedRhea 27806

2 isopentenyl diphosphate + dimethylallyl diphosphate = (2Z,6Z)-farnesyl diphosphate + 2 diphosphate

Direction not assertedBalancedRhea 27810

acetate(in) + Na(+)(in) = acetate(out) + Na(+)(out)

Direction not assertedBalancedTransportRhea 27814

L-idonate + NAD(+) = 2-dehydro-L-idonate + NADH + H(+)

Direction not assertedBalancedRhea 27818

O-acetyl-L-homoserine + hydrogen sulfide = L-homocysteine + acetate

Direction not assertedBalancedRhea 27822

O-succinyl-L-homoserine + hydrogen sulfide = L-homocysteine + succinate

Direction not assertedBalancedRhea 27826

neryl diphosphate = beta-phellandrene + diphosphate

Direction not assertedBalancedRhea 27830

a menaquinone + succinate = a menaquinol + fumarate

Direction not assertedBalance undeterminableRhea 27834

9H-carbazole + NADH + O2 + H(+) = 2'-aminobiphenyl-2,3-diol + NAD(+)

Direction not assertedBalancedRhea 27838

9H-carbazole + NADPH + O2 + H(+) = 2'-aminobiphenyl-2,3-diol + NADP(+)

Direction not assertedBalancedRhea 27842

(2E)-3-(3-hydroxyphenyl)prop-2-enoate + NADH + O2 + H(+) = (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + NAD(+) + H2O

Direction not assertedBalancedRhea 27846

phenylacetyl-CoA + glycine = phenylacetylglycine + CoA + H(+)

Direction not assertedBalancedRhea 27850

4-hydroxybenzoate + (2E)-geranyl diphosphate = 3-geranyl-4-hydroxybenzoate + diphosphate

Direction not assertedBalancedRhea 27854

2',3'-cyclophospho-GMP + H2O = 3'-GMP + H(+)

Direction not assertedBalancedRhea 27858

3'-GMP + H2O = guanosine + phosphate

Direction not assertedBalancedRhea 27862

(2R)-2-O-(6-phospho-alpha-D-mannosyl)-glycerate + H2O = alpha-D-mannose 6-phosphate + (R)-glycerate

Direction not assertedBalancedRhea 27866

(2E,4E)-6-(2-aminophenyl)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + anthranilate + H(+)

Direction not assertedBalancedRhea 27870

isochorismate = salicylate + pyruvate

Direction not assertedBalancedRhea 27874

2',3'-cyclophospho-UMP + H2O = 3'-UMP + H(+)

Direction not assertedBalancedRhea 27878

2',3'-cyclophospho-CMP + H2O = 3'-CMP + H(+)

Direction not assertedBalancedRhea 27882

2',3'-cyclophospho-AMP + H2O = 3'-AMP + H(+)

Direction not assertedBalancedRhea 27886

3'-UMP + H2O = uridine + phosphate

Direction not assertedBalancedRhea 27890

3'-CMP + H2O = cytidine + phosphate

Direction not assertedBalancedRhea 27894

3'-AMP + H2O = adenosine + phosphate

Direction not assertedBalancedRhea 27898

ubiquinone-0 + caffeine + H2O = ubiquinol-0 + 1,3,7-trimethylurate

Direction not assertedBalancedRhea 27902

butanoyl-CoA + NADP(+) = (2E)-butenoyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 27906

4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H2O = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + phosphate + H(+)

Direction not assertedBalancedRhea 27914

propanal + NADP(+) + H2O = propanoate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 27918

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