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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

16,951–17,000 of 31,435, by identifier

5-methylsulfanyl-2,3-dioxopentyl phosphate + O2 + H2O = 4-methylsulfanyl-2-oxobutanoate + formate + phosphate + 2 H(+)
Direction not assertedBalancedRhea 27922
UMP(in) = UMP(out)
Direction not assertedBalancedTransportRhea 27926
(R)-4-phosphopantoate + beta-alanine + ATP = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+)
Direction not assertedBalancedRhea 27930
(3S)-3-hydroxy-D-aspartate = glyoxylate + glycine
Direction not assertedBalancedRhea 27934
(3R)-3-hydroxy-D-aspartate = glyoxylate + glycine
Direction not assertedBalancedRhea 27938
(3R)-3-hydroxy-D-aspartate = oxaloacetate + NH4(+)
Direction not assertedBalancedRhea 27942
dopamine + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4(+)

Direction not assertedBalancedRhea 27946

L-phenylalanine(in) = L-phenylalanine(out)

ReversibleBalancedTransportRhea 27950

(2E,6E)-farnesyl diphosphate + H2O = presilphiperfolan-8beta-ol + diphosphate

Direction not assertedBalancedRhea 27954

cytidine + H2O = cytosine + D-ribose

Direction not assertedBalancedRhea 27958

pyrroloquinoline quinone + myo-inositol = pyrroloquinoline quinol + scyllo-inosose + H(+)

Direction not assertedBalancedRhea 27962

7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + triphosphate + acetaldehyde + 2 H(+)

Direction not assertedBalancedRhea 27966

D-maltotriose + H2O = D-maltose + alpha-D-glucose

Left to rightBalancedRhea 27970

6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-carbaguanine + NH4(+)

Direction not assertedBalancedRhea 27974

GDP-alpha-D-mannose + H2O = alpha-D-mannose 1-phosphate + GMP + 2 H(+)

Direction not assertedBalancedRhea 27978

7-carboxy-7-carbaguanine + NH4(+) + 2 ATP = 7-cyano-7-carbaguanine + 2 AMP + 2 diphosphate + 2 H(+)

Direction not assertedBalancedRhea 27982

hydroxyacetone + NADP(+) = methylglyoxal + NADPH + H(+)

Right to leftBalancedRhea 27986

1-deoxy-D-xylulose + ATP = 1-deoxy-D-xylulose 5-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 27990

xanthosine + H2O = D-ribose + xanthine

Direction not assertedBalancedRhea 27994

thiamine diphosphate + H2O = thiamine phosphate + phosphate + H(+)

Direction not assertedBalancedRhea 27998

beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate

Direction not assertedBalancedRhea 28002

N(alpha)-methyl-L-tryptophan + O2 + H2O = L-tryptophan + formaldehyde + H2O2

Direction not assertedBalancedRhea 28006

propanoyl-CoA + succinate = propanoate + succinyl-CoA

Direction not assertedBalancedRhea 28010

thiocyanate + S-adenosyl-L-methionine = methyl thiocyanate + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 28014

enterobactin + 3 H2O = 3 N-(2,3-dihydroxybenzoyl)-L-serine + 2 H(+)

Direction not assertedBalancedRhea 28018

octanoate + holo-[ACP] + ATP = octanoyl-[ACP] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 28022

dUDP + [thioredoxin]-disulfide + H2O = [thioredoxin]-dithiol + UDP

Direction not assertedBalance undeterminableRhea 28026

dGDP + [thioredoxin]-disulfide + H2O = [thioredoxin]-dithiol + GDP

Direction not assertedBalance undeterminableRhea 28030

dADP + [thioredoxin]-disulfide + H2O = [thioredoxin]-dithiol + ADP

Direction not assertedBalance undeterminableRhea 28034

dCDP + [thioredoxin]-disulfide + H2O = CDP + [thioredoxin]-dithiol

Direction not assertedBalance undeterminableRhea 28038

pyruvate + NAD(+) + CoA = acetyl-CoA + CO2 + NADH

Direction not assertedBalancedRhea 28042

propanoyl-CoA + phosphate = propanoyl phosphate + CoA

Direction not assertedBalancedRhea 28046

NADP(+) + H2O = phosphate + NAD(+)

Left to rightBalancedRhea 28050

2-oxobutanoate + CoA = propanoyl-CoA + formate

Direction not assertedBalancedRhea 28054

L-lyxopyranose = L-xylulose

Direction not assertedBalancedRhea 28058

alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)

Direction not assertedBalancedRhea 28062

lipid IVA (E. coli) + CMP-3-deoxy-beta-D-manno-octulosonate = alpha-Kdo-(2->6)-lipid IVA (E. coli) + CMP + H(+)

Direction not assertedBalancedRhea 28066

heme b + (2E,6E)-farnesyl diphosphate + H2O = Fe(II)-heme o + diphosphate

Direction not assertedBalancedRhea 28070

(2R)-3-sulfopropanediol + 2 NAD(+) + H2O = (2R)-3-sulfolactate + 2 NADH + 3 H(+)

Direction not assertedBalancedRhea 28074

2-hydroxyethylphosphonate + NAD(+) = phosphonoacetaldehyde + NADH + H(+)

Direction not assertedBalancedRhea 28078

(2S)-ethylmalonyl-CoA + NADP(+) = (2E)-butenoyl-CoA + CO2 + NADPH

Direction not assertedBalancedRhea 28082

Reactive Blue 5 + 2 H2O2 = 2,2'-disulfonyl azobenzene + 3-[(4-amino-6-chloro-1,3,5-triazin-2-yl)amino]benzenesulfonate + phthalate + 2 H2O + 2 H(+)

Direction not assertedBalancedRhea 28086

di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP

Direction not assertedBalancedRhea 28090

di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + phosphate + H(+)

Direction not assertedBalancedRhea 28094

GDP + ATP = guanosine 3',5'-bis(diphosphate) + AMP

Direction not assertedBalancedRhea 28098

GDP-alpha-D-mannose + H2O = D-mannose + GDP + H(+)

Direction not assertedBalancedRhea 28102

galactitol 1-phosphate + NAD(+) = keto-D-tagatose 6-phosphate + NADH + H(+)

Direction not assertedBalancedRhea 28106

chloride + S-adenosyl-L-methionine = 5'-chloro-5'-deoxyadenosine + L-methionine

Direction not assertedBalancedRhea 28110

di-trans,octa-cis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl di-trans,octa-cis-undecaprenyl phosphate + GDP

Direction not assertedBalancedRhea 28118

di-trans,octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H(+)

Direction not assertedBalancedRhea 28122

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