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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

Atlas Graph Twin Access

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

16,851–16,900 of 31,435, by identifier

cocaine + H2O = ecgonine methyl ester + benzoate + H(+)
Direction not assertedBalancedRhea 27506
enolpyruvoyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-hydroxy-5-deazariboflavin = dehydro coenzyme F420-0 + GMP + H(+)
Direction not assertedBalancedRhea 27510
sphinganine 1-phosphate + H2O = sphinganine + phosphate
Left to rightBalancedRhea 27514
sphing-4-enine 1-phosphate + H2O = sphing-4-enine + phosphate
Left to rightBalancedRhea 27518
2,5-dihydroxypyridine + O2 = N-formylmaleamate + H(+)
Direction not assertedBalancedRhea 27522
(2E,6E)-farnesyl diphosphate + H2O = (2E,6E)-farnesol + diphosphate
Direction not assertedBalancedRhea 27526
(2E,6E)-farnesyl diphosphate + H2O = (3S,6E)-nerolidol + diphosphate

Direction not assertedBalancedRhea 27530

(2E,6E)-farnesyl diphosphate + H2O = (3R,6E)-nerolidol + diphosphate

Direction not assertedBalancedRhea 27534

N,N-dimethyl-4-nitrosoaniline + ethanol = 4-(hydroxylamino)-N,N-dimethylaniline + acetaldehyde

Direction not assertedBalancedRhea 27538

N,N-dimethyl-4-nitrosoaniline + methanol = 4-(hydroxylamino)-N,N-dimethylaniline + formaldehyde

Direction not assertedBalancedRhea 27542

anthranilate + FADH2 + O2 = 3-hydroxyanthranilate + FAD + H2O + H(+)

Direction not assertedBalancedRhea 27546

8 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate

Direction not assertedBalancedRhea 27551

2 isopentenyl diphosphate + (2E,6E,10E)-geranylgeranyl diphosphate = all-trans-hexaprenyl diphosphate + 2 diphosphate

Direction not assertedBalancedRhea 27555

3 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = all-trans-hexaprenyl diphosphate + 3 diphosphate

Direction not assertedBalancedRhea 27559

7 isopentenyl diphosphate + (2E)-geranyl diphosphate = all-trans-nonaprenyl diphosphate + 7 diphosphate

Direction not assertedBalancedRhea 27563

D-glycero-alpha-D-manno-heptose 7-phosphate + ATP = D-glycero-alpha-D-manno-heptose 1,7-bisphosphate + ADP + H(+)

Direction not assertedBalancedRhea 27570

(3R)-piperidine-3-carboxamide + H2O = (3R)-piperidine-3-carboxylate + NH4(+)

Direction not assertedBalancedRhea 27574

(R)-N-tert-butylpiperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + tert-butylamine

Direction not assertedBalancedRhea 27578

(S)-2-hydroxymethylglutarate = 2-methyleneglutarate + H2O

Direction not assertedBalancedRhea 27582

L-tryptophan + pyruvate = indole-3-pyruvate + L-alanine

Direction not assertedBalancedRhea 27586

(R)-pantoate + beta-alanine + ATP = (R)-pantothenate + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 27590

5 isopentenyl diphosphate + (2E,6E,10E)-geranylgeranyl diphosphate = all-trans-nonaprenyl diphosphate + 5 diphosphate

Direction not assertedBalancedRhea 27594

(2Z,6E)-farnesyl diphosphate + 9 isopentenyl diphosphate = di-trans,nona-cis-dodecaprenyl diphosphate + 9 diphosphate

Direction not assertedBalancedRhea 27602

a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + ethanolamine

Left to rightBalance undeterminableRhea 27606

formate + H(+) = H2 + CO2

Direction not assertedBalancedRhea 27610

(2Z,6E)-farnesyl diphosphate + 10 isopentenyl diphosphate = di-trans,deca-cis-tridecaprenyl diphosphate + 10 diphosphate

Direction not assertedBalancedRhea 27614

(2Z,6E)-farnesyl diphosphate + 11 isopentenyl diphosphate = di-trans,undeca-cis-tetradecaprenyl diphosphate + 11 diphosphate

Direction not assertedBalancedRhea 27618

geranylgeranyl diphosphate + 7 isopentenyl diphosphate = tri-trans,hepta-cis-undecaprenyl diphosphate + 7 diphosphate

Direction not assertedBalancedRhea 27622

D-erythrose 4-phosphate + D-xylulose 5-phosphate = beta-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate

Direction not assertedBalancedRhea 27626

ethylene glycol + NAD(+) = glycolaldehyde + NADH + H(+)

Direction not assertedBalancedRhea 27630

5-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + NADPH + H(+)

Direction not assertedBalancedRhea 27634

xanthosine + phosphate = alpha-D-ribose 1-phosphate + xanthine

Direction not assertedBalancedRhea 27638

adenosine + phosphate = alpha-D-ribose 1-phosphate + adenine

Left to rightBalancedRhea 27642

inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine

Left to rightBalancedRhea 27646

uridine + GTP = UMP + GDP + H(+)

Direction not assertedBalancedRhea 27650

2-oxobutanoate + pyruvate + H(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + CO2

Direction not assertedBalancedRhea 27654

2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate

Direction not assertedBalancedRhea 27658

(S)-2-hydroxyglutarate + O2 = 2-oxoglutarate + H2O2

Direction not assertedBalancedRhea 27662

(R)-methylmalonyl-CoA + H(+) = propanoyl-CoA + CO2

Direction not assertedBalancedRhea 27666

1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate

Left to rightBalancedRhea 27670

dADP + ATP = dATP + ADP

Direction not assertedBalancedRhea 27674

dCDP + ATP = dCTP + ADP

ReversibleBalancedRhea 27678

dTDP + ATP = dTTP + ADP

Left to rightBalancedRhea 27682

GDP + ATP = GTP + ADP

Left to rightBalancedRhea 27686

dGDP + ATP = dGTP + ADP

Left to rightBalancedRhea 27690

(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O

Direction not assertedBalancedRhea 27694

GDP-beta-L-galactose + phosphate = beta-L-galactose 1-phosphate + GDP + H(+)

Direction not assertedBalancedRhea 27698

aldehydo-D-galacturonate = keto-D-tagaturonate

Direction not assertedBalancedRhea 27702

D-serine + D-alanine + ATP = D-alanyl-D-serine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 27706

guanosine + ATP = GMP + ADP + H(+)

Direction not assertedBalancedRhea 27710

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