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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

16,751–16,800 of 31,435, by identifier

all-trans-beta-carotene + O2 = beta-ionone + all-trans-10'-apo-beta-carotenal
Left to rightBalancedRhea 26389
all-trans-zeaxanthin + 2 O2 = 4,9-dimethyldodeca-2,4,6,8,10-pentaenedial + 2 (3R)-hydroxy-beta-ionone
Left to rightBalancedRhea 26393
all-trans-zeaxanthin + 2 O2 = crocetin dialdehyde + 2 3beta-hydroxy-beta-cyclocitral
Direction not assertedBalancedRhea 26397
all-trans-10'-apo-beta-carotenal + O2 = (2E,4E,6E)-4-methylocta-2,4,6-trienedial + 13-apo-beta-carotenone
Direction not assertedBalancedRhea 26401
aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH4(+) = pyridoxal 5'-phosphate + phosphate + 4 H2O + H(+)
Direction not assertedBalancedRhea 26405
N-acetyl-D-muramate 6-phosphate + H2O = N-acetyl-D-glucosamine 6-phosphate + (R)-lactate
Direction not assertedBalancedRhea 26410

a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2

Direction not assertedBalance undeterminableRhea 26414

(3R)-3-hydroxy-8'-apo-beta-carotenal + O2 = (2E,4E,6E)-2,6-dimethylocta-2,4,6-trienedial + (3R)-all-trans-3-hydroxyretinal

Direction not assertedBalancedRhea 26418

thyroxine + 3'-phosphoadenylyl sulfate = thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 26422

UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)

Left to rightBalancedRhea 26426

(+)-copalyl diphosphate + H2O = phyllocladan-16alpha-ol + diphosphate

Direction not assertedBalancedRhea 26430

indole + L-serine = L-tryptophan + H2O

Direction not assertedBalancedRhea 26434

3-hydroxypropanoate + NADP(+) = 3-oxopropanoate + NADPH + H(+)

Direction not assertedBalancedRhea 26438

ethanol + a ubiquinone = a ubiquinol + acetaldehyde

Direction not assertedBalance undeterminableRhea 26442

3-oxopropanoate + NADP(+) + CoA = malonyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 26446

succinate semialdehyde + NADP(+) + CoA = succinyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 26450

propanoyl-CoA + NADP(+) = acryloyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 26454

ethylnitronate + FMNH2 + O2 = acetaldehyde + FMN + nitrite + H2O + 2 H(+)

Direction not assertedBalancedRhea 26458

6-methoxy-2-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-methionine = 2-methoxy-5-methyl-6-all-trans-octaprenyl-1,4-benzoquinone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 26462

a 2-demethylmenaquinone + S-adenosyl-L-methionine = a menaquinone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 26466

16-hydroxyhexadecanoate + (E)-feruloyl-CoA = 16-feruloyloxyhexadecanoate + CoA

Direction not assertedBalancedRhea 26470

beta-D-galactosyl-(1->4)-L-rhamnose + phosphate = alpha-D-galactose 1-phosphate + L-rhamnopyranose

Direction not assertedBalancedRhea 26474

an all-trans-polyprenyl diphosphate + 1,4-dihydroxy-2-naphthoate + H(+) = a 2-demethylmenaquinol + CO2 + diphosphate

Direction not assertedBalance undeterminableRhea 26478

adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate

Direction not assertedBalancedRhea 26482

O-phospho-L-serine + sulfite + H(+) = L-cysteate + phosphate

Direction not assertedBalancedRhea 26486

a secondary nitroalkane + O2 + H2O = a ketone + nitrite + H2O2 + H(+)

Direction not assertedBalance undeterminableRhea 26490

L-tryptophan + FADH2 + chloride + O2 = 7-chloro-L-tryptophan + FAD + 2 H2O

Direction not assertedBalancedRhea 26494

delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside + UDP-alpha-D-glucose = delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP

Direction not assertedBalancedRhea 26498

delphinidin 3-O-(6''-O-malonyl)-beta-D-glucoside-3'-O-beta-D-glucoside + UDP-alpha-D-glucose = ternatin C5 + UDP + 2 H(+)

Direction not assertedBalancedRhea 26502

(9Z)-octadecenamide + H2O = (9Z)-octadecenoate + NH4(+)

Left to rightBalancedRhea 26506

L-prolinamide + H2O = L-proline + NH4(+)

Direction not assertedBalancedRhea 26510

cyclohexan-1,2-dione + H2O = 6-oxohexanoate + H(+)

Direction not assertedBalancedRhea 26514

3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O

Right to leftBalancedRhea 26518

(2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O

Direction not assertedBalancedRhea 26522

a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O

Right to leftBalance undeterminableRhea 26526

4-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O

Direction not assertedBalancedRhea 26530

3-hydroxypropanoate + ATP + CoA = 3-hydroxypropanoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 26534

(R)-piperazine-2-carboxamide + H2O = (R)-piperazine-2-carboxylate + NH4(+)

Direction not assertedBalancedRhea 26542

beta-alaninamide + H2O = beta-alanine + NH4(+)

Direction not assertedBalancedRhea 26546

(S)-piperazine-2-carboxamide + H2O = (S)-piperazine-2-carboxylate + NH4(+)

Direction not assertedBalancedRhea 26550

angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine

Left to rightBalancedRhea 26554

(3S)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O

Right to leftBalancedRhea 26558

2-succinylbenzoyl-CoA + H(+) = 1,4-dihydroxy-2-naphthoyl-CoA + H2O

Direction not assertedBalancedRhea 26562

hexadecanal + NADP(+) + CoA = hexadecanoyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 27270

2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)

Direction not assertedBalancedRhea 27274

2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 27278

2-amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + formate + H(+)

Direction not assertedBalancedRhea 27282

(S)-acetoin + NAD(+) = diacetyl + NADH + H(+)

Direction not assertedBalancedRhea 27286

formate + A + H(+) = AH2 + CO2

Direction not assertedBalancedRhea 27290

oxidized coenzyme F420-(gamma-L-Glu)(n) + D-glucose 6-phosphate + H(+) = 6-phospho-D-glucono-1,5-lactone + reduced coenzyme F420-(gamma-L-Glu)(n)

Direction not assertedBalance undeterminableRhea 27294

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