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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

16,551–16,600 of 31,435, by identifier

(2E,6E,10E)-geranylgeranyl diphosphate = 9alpha-copalyl diphosphate
Direction not assertedBalancedRhea 25524
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate
Left to rightBalance undeterminableRhea 25528
ent-copalyl diphosphate = ent-cassa-12,15-diene + diphosphate
Direction not assertedBalancedRhea 25532
ent-copalyl diphosphate = ent-sandaracopimara-8(14),15-diene + diphosphate
Direction not assertedBalancedRhea 25536
ent-copalyl diphosphate = ent-pimara-8(14),15-diene + diphosphate
Direction not assertedBalancedRhea 25540
ent-copalyl diphosphate = ent-pimara-9(11),15-diene + diphosphate
Direction not assertedBalancedRhea 25544
(+)-copalyl diphosphate = abieta-8(14),12-diene + diphosphate

Direction not assertedBalancedRhea 25548

9alpha-copalyl diphosphate = stemar-13-ene + diphosphate

Direction not assertedBalancedRhea 25552

9alpha-copalyl diphosphate = stemod-13(17)-ene + diphosphate

Direction not assertedBalancedRhea 25556

9alpha-copalyl diphosphate = 9beta-pimara-7,15-diene + diphosphate

Direction not assertedBalancedRhea 25560

N-acetyl-4-O-acetylneuraminate + H2O = N-acetylneuraminate + acetate + H(+)

Direction not assertedBalancedRhea 25564

beta-D-ribosylnicotinate + ATP = nicotinate beta-D-ribonucleotide + ADP + H(+)

Direction not assertedBalancedRhea 25568

protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2

Direction not assertedBalancedRhea 25576

alpha-L-fucose = beta-L-fucose

Direction not assertedBalancedRhea 25580

alpha-L-rhamnose = beta-L-rhamnose

Direction not assertedBalancedRhea 25584

D-threo-isocitrate + NADP(+) = (S)-oxalosuccinate + NADPH + H(+)

Direction not assertedBalancedRhea 25588

isochorismate + 2-oxoglutarate + H(+) = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2

Direction not assertedBalancedRhea 25593

5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate

Direction not assertedBalancedRhea 25597

4-methylsulfanyl-2-oxobutanoate + acetyl-CoA + H2O = 2-(2-methylsulfanyl)ethylmalate + CoA + H(+)

Direction not assertedBalancedRhea 25601

2-(5-methylsulfanyl)oxopentanoate + acetyl-CoA + H2O = 2-(3-methylsulfanyl)propylmalate + CoA + H(+)

Direction not assertedBalancedRhea 25605

beta-D-allofuranose = beta-D-allopyranose

Direction not assertedBalancedRhea 25609

(2E,6E,10E)-geranylgeranyl diphosphate = terpentedienyl diphosphate

Direction not assertedBalancedRhea 25613

terpentedienyl diphosphate = terpentetriene + diphosphate

Direction not assertedBalancedRhea 25617

geranylgeranyl diphosphate = tuberculosinyl diphosphate

Direction not assertedBalancedRhea 25621

histamine + O2 + H2O = imidazole-4-acetaldehyde + H2O2 + NH4(+)

Left to rightBalancedRhea 25625

myricetin + S-adenosyl-L-methionine = laricitrin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 25629

laricitrin + S-adenosyl-L-methionine = syringetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 25633

sulfoacetaldehyde + NAD(+) + H2O = sulfoacetate + NADH + 2 H(+)

Direction not assertedBalancedRhea 25637

(1R,4S)-menthone + NADP(+) = (R)-pulegone + NADPH + H(+)

Direction not assertedBalancedRhea 25641

(2R,5R)-isomenthone + NADP(+) = (R)-pulegone + NADPH + H(+)

Direction not assertedBalancedRhea 25645

(2R,5R)-isopulegone + NADP(+) = (6R)-isopiperitenone + NADPH + H(+)

Direction not assertedBalancedRhea 25649

(2S)-2-amino-3-oxobutanoate + H(+) = aminoacetone + CO2

Direction not assertedBalancedRhea 25653

(R)-pulegone + reduced [NADPH--hemoprotein reductase] + O2 = (R)-menthofuran + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 25658

(2E)-geranyl diphosphate = alpha-pinene + diphosphate

Direction not assertedBalancedRhea 25662

(2E)-geranyl diphosphate = beta-pinene + diphosphate

Direction not assertedBalancedRhea 25666

sucrose + UDP-alpha-D-galactose = loliose + UDP + H(+)

Direction not assertedBalancedRhea 25670

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate

Direction not assertedBalance undeterminableRhea 25674

tRNA(Cys) + O-phospho-L-serine + ATP = O-phospho-L-seryl-tRNA(Cys) + AMP + diphosphate

Direction not assertedBalancedRhea 25678

L-dihomomethionine + reduced [NADPH--hemoprotein reductase] + O2 = N-hydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 25682

O-phospho-L-seryl-tRNA(Cys) + hydrogen sulfide + H(+) = L-cysteinyl-tRNA(Cys) + phosphate

Direction not assertedBalancedRhea 25686

2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + CTP + H(+) = CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol + diphosphate

Direction not assertedBalancedRhea 25690

isopentenyl diphosphate + (2E,6E,10E)-geranylgeranyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate

Direction not assertedBalancedRhea 25694

N,N-dihydroxy-L-hexahomomethionine + H(+) = (E)-9-(methylsulfanyl)nonanal oxime + CO2 + H2O

Direction not assertedBalancedRhea 25698

N-hydroxy-L-dihomomethionine + reduced [NADPH--hemoprotein reductase] + O2 = N,N-dihydroxy-L-dihomomethionine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 25702

N,N-dihydroxy-L-dihomomethionine + H(+) = (E)-5-(methylsulfanyl)pentanal oxime + CO2 + H2O

Direction not assertedBalancedRhea 25706

L-trihomomethionine + reduced [NADPH--hemoprotein reductase] + O2 = N-hydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 25711

N-hydroxy-L-trihomomethionine + reduced [NADPH--hemoprotein reductase] + O2 = N,N-dihydroxy-L-trihomomethionine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 25715

N,N-dihydroxy-L-trihomomethionine + H(+) = (E)-6-(methylsulfanyl)hexanal oxime + CO2 + H2O

Direction not assertedBalancedRhea 25719

L-tetrahomomethionine + reduced [NADPH--hemoprotein reductase] + O2 = N-hydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 25723

N-hydroxy-L-tetrahomomethionine + reduced [NADPH--hemoprotein reductase] + O2 = N,N-dihydroxy-L-tetrahomomethionine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 25727

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