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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

16,151–16,200 of 31,435, by identifier

pyridoxal + O2 + H2O = 4-pyridoxate + H2O2 + H(+)
Direction not assertedBalancedRhea 23724
(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
Left to rightBalancedRhea 23728
(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + CO2 + phosphate
Direction not assertedBalancedRhea 23732
5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)
Direction not assertedBalancedRhea 23736
L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
Direction not assertedBalancedRhea 23744
GTP + ATP = pppGp(2'-5')A + diphosphate
Left to rightBalancedRhea 23748
all-trans-undecaprenol + ATP = all-trans-undecaprenyl phosphate + ADP + H(+)

Direction not assertedBalancedRhea 23752

D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 + H(+)

Direction not assertedBalancedRhea 23756

oxidized coenzyme F420-(gamma-L-Glu)(n) + H2 + H(+) = reduced coenzyme F420-(gamma-L-Glu)(n)

Direction not assertedBalance undeterminableRhea 23760

L-serine + diphosphate = O-phospho-L-serine + phosphate + H(+)

Direction not assertedBalancedRhea 23764

sphing-4-enine + a fatty acyl-CoA = an N-acylsphing-4-enine + CoA + H(+)

Left to rightBalance undeterminableRhea 23768

(2R,3S)-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + NADH + H(+)

Direction not assertedBalancedRhea 23772

L-aspartate + ATP = 4-phospho-L-aspartate + ADP

Direction not assertedBalancedRhea 23776

propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)

Direction not assertedBalancedRhea 23780

L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)

Direction not assertedBalance undeterminableRhea 23784

holo-[citrate lyase ACP] + acetate + ATP = acetyl-[citrate lyase ACP] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 23788

17-O-acetylnorajmaline + H2O = norajmaline + acetate + H(+)

Direction not assertedBalancedRhea 23796

L-methionine + H2O = methanethiol + 2-oxobutanoate + NH4(+)

Direction not assertedBalancedRhea 23800

N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate

Direction not assertedBalancedRhea 23804

(S)-scoulerine + S-adenosyl-L-methionine = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 23808

(+)-neomenthol + NADP(+) = (1R,4S)-menthone + NADPH + H(+)

Direction not assertedBalancedRhea 23812

putrescine + 2-oxoglutarate = 4-aminobutanal + L-glutamate

Direction not assertedBalancedRhea 23816

GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O

Left to rightBalancedRhea 23820

(2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + NADH + H(+)

Direction not assertedBalancedRhea 23824

2-dehydro-D-gluconate + NADP(+) = 2,5-didehydro-D-gluconate + NADPH + H(+)

Direction not assertedBalancedRhea 23828

an N-acyl-D-mannosamine + ATP = an N-acyl-D-mannosamine 6-phosphate + ADP + H(+)

Left to rightBalance undeterminableRhea 23832

D-methionine + pyruvate = 4-methylsulfanyl-2-oxobutanoate + L-alanine

Direction not assertedBalancedRhea 23836

3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)

Direction not assertedBalancedRhea 23840

sedoheptulose + ATP = D-sedoheptulose 7-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 23844

catechol + O2 = cis,cis-muconate + 2 H(+)

Direction not assertedBalancedRhea 23852

Hg + NADP(+) + H(+) = Hg(2+) + NADPH

Direction not assertedBalancedRhea 23856

deacetylcephalosporin C + acetyl-CoA = cephalosporin C + CoA

Direction not assertedBalancedRhea 23860

4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP

Direction not assertedBalancedRhea 23864

(1-hydroxycyclohexan-1-yl)acetyl-CoA = cyclohexanone + acetyl-CoA

Direction not assertedBalancedRhea 23868

(R)-propane-1,2-diol + NAD(+) = (R)-lactaldehyde + NADH + H(+)

Direction not assertedBalancedRhea 23872

protoaphin aglucone = xanthoaphin + H2O

Direction not assertedBalancedRhea 23876

L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate

Direction not assertedBalance undeterminableRhea 23880

nicotinamide + S-adenosyl-L-methionine = 1-methylnicotinamide + S-adenosyl-L-homocysteine

Left to rightBalancedRhea 23884

[L-4-(L-arginin-2-N-yl)aspartate](n)-L-aspartate + L-arginine + ATP = [L-4-(L-arginin-2-N-yl)aspartate](n+1) + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 23888

3-nitropropanoate + NADP(+) = 3-nitroacrylate + NADPH + H(+)

Direction not assertedBalancedRhea 23892

5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate

Direction not assertedBalancedRhea 23896

cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin

Left to rightBalancedRhea 23900

an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]

ReversibleBalance undeterminableRhea 23904

2 methylcob(III)alamin-[methionine synthase] + 2 S-adenosyl-L-homocysteine + NADP(+) + H(+) = 2 cob(II)alamin-[methionine synthase] + 2 S-adenosyl-L-methionine + NADPH

Right to leftBalance undeterminableRhea 23908

UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2

Left to rightBalancedRhea 23916

(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate

Direction not assertedBalancedRhea 23920

pppGp(2'-5')A = 2',3'-cGAMP + diphosphate

Left to rightBalancedRhea 23924

N(8)-acetylspermidine + H2O = spermidine + acetate

Direction not assertedBalancedRhea 23928

an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine 6-phosphate

Direction not assertedBalance undeterminableRhea 23932

D-gluconate + NADP(+) = 5-dehydro-D-gluconate + NADPH + H(+)

Direction not assertedBalancedRhea 23936

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