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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Cell types
Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

15,951–16,000 of 31,435, by identifier

ent-7alpha-hydroxykaur-16-en-19-oate + reduced [NADPH--hemoprotein reductase] + O2 = gibberellin A12 aldehyde + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)
Direction not assertedBalance undeterminableRhea 22904
3',5'-cyclic AMP + H2O + H(+) = 3',5'-cyclic IMP + NH4(+)
Direction not assertedBalancedRhea 22908
L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine
Direction not assertedBalancedRhea 22912
4'-hydroxyacetophenone + NADPH + O2 + H(+) = 4-acetoxyphenol + NADP(+) + H2O
Direction not assertedBalancedRhea 22916
scyllo-inosose + L-glutamine = 1-amino-1-deoxy-scyllo-inositol + 2-oxoglutaramate
Direction not assertedBalancedRhea 22920
dCMP + H2O + H(+) = dUMP + NH4(+)
Left to rightBalancedRhea 22924
4-acetamidobutanoyl-CoA + H2O = 4-aminobutanoyl-CoA + acetate

Direction not assertedBalancedRhea 22928

an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)

Left to rightBalance undeterminableRhea 22932

N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

Direction not assertedBalancedRhea 22936

L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + H(+)

Direction not assertedBalancedRhea 22940

3beta-hydroxy-5beta-pregnane-20-one + NADP(+) = 5beta-pregnan-3,20-dione + NADPH + H(+)

Right to leftBalancedRhea 22944

D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate

Direction not assertedBalancedRhea 22948

octanedioyl-CoA + O2 = (2E)-octenedioyl-CoA + H2O2

Direction not assertedBalancedRhea 22952

a 1-(1,2-saturated alkyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + 2 Fe(III)-[cytochrome b5] + 2 H2O

Left to rightBalance undeterminableRhea 22956

formononetin + reduced [NADPH--hemoprotein reductase] + O2 = calycosin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 22960

L-ornithine + H(+) = putrescine + CO2

Direction not assertedBalancedRhea 22964

butanal + NAD(+) + CoA = butanoyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 22968

butanal + NADP(+) + CoA = butanoyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 22972

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + ATP + CoA = (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 22976

a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)

Direction not assertedBalance undeterminableRhea 22980

oxamate + carbamoyl phosphate = N-carbamoyl-2-oxoglycine + phosphate

Direction not assertedBalancedRhea 22984

3-oxopropanoate + NADP(+) + CoA = acetyl-CoA + CO2 + NADPH

Direction not assertedBalancedRhea 22988

3-oxopropanoate + NAD(+) + CoA = acetyl-CoA + CO2 + NADH

Direction not assertedBalancedRhea 22992

L-ascorbate + H2O2 = L-dehydroascorbate + 2 H2O

Direction not assertedBalancedRhea 22996

(R)-pantoate + NAD(+) = (R)-4-dehydropantoate + NADH + H(+)

Direction not assertedBalancedRhea 23000

a neolactoside nLc4Cer(d18:1(4E)) + UDP-N-acetyl-alpha-D-glucosamine = a neolactoside IV(3)-beta-GlcNAc-nLc4Cer(d18:1(4E)) + UDP + H(+)

Left to rightBalance undeterminableRhea 23004

alpha,alpha-trehalose 6-phosphate + H2O = D-glucose 6-phosphate + D-glucose

Direction not assertedBalancedRhea 23008

a fatty acid + S-adenosyl-L-methionine = a fatty acid methyl ester + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 23012

(2R,3S,4S)-3,4-leucopelargonidin + NADP(+) = (2R,3R)-dihydrokaempferol + NADPH + H(+)

Direction not assertedBalancedRhea 23016

[(1->4)-beta-D-glucosyl](n) + phosphate = [(1->4)-beta-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate

Direction not assertedBalance undeterminableRhea 23024

N(6)-biotinyl-L-lysyl-[protein] + malonyl-[ACP] = N(6)-carboxybiotinyl-L-lysyl-[protein] + acetyl-[ACP]

Direction not assertedBalance undeterminableRhea 23028

2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)

Left to rightBalancedRhea 23032

2 inosine + O2 = 2 5'-dehydroinosine + 2 H2O

Direction not assertedBalancedRhea 23036

2-oxobutanoate + acetyl-CoA + H2O = (R)-2-ethylmalate + CoA + H(+)

Direction not assertedBalancedRhea 23040

N,N-dihydroxy-L-tyrosine + H(+) = (E)-4-hydroxyphenylacetaldehyde oxime + CO2 + H2O

Direction not assertedBalancedRhea 23044

(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate

Direction not assertedBalancedRhea 23048

L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 23052

urea = cyanamide + H2O

Direction not assertedBalancedRhea 23056

a (2R,3S)-2-alkyl-3-hydroxyalkanoate + ATP = a cis-3-alkyl-4-alkyloxetan-2-one + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 23060

an alkanesulfonate + FMNH2 + O2 = an aldehyde + FMN + sulfite + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 23064

6 (S)-methylmalonyl-CoA + propanoyl-CoA + 6 NADPH + 12 H(+) = 6-deoxyerythronolide B + 6 CO2 + 6 NADP(+) + 7 CoA + H2O

Direction not assertedBalancedRhea 23068

4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH

Direction not assertedBalancedRhea 23076

L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O

Direction not assertedBalancedRhea 23080

3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 7-methyl-3-oxooct-6-enoyl-CoA + acetate

Direction not assertedBalancedRhea 23084

O-alkylglycerone + ATP = a 1-O-alkylglycerone 3-phosphate + ADP + H(+)

Direction not assertedBalance undeterminableRhea 23088

hydroxyatrazine + H2O + H(+) = N-isopropylammelide + ethylamine

Direction not assertedBalancedRhea 23092

4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)

Direction not assertedBalancedRhea 23096

dAMP + ATP = dADP + ADP

Direction not assertedBalancedRhea 23100

D-arabinose 5-phosphate = D-ribulose 5-phosphate

Direction not assertedBalancedRhea 23104

D-arabinono-1,4-lactone + H2O = D-arabinonate + H(+)

Direction not assertedBalancedRhea 23108

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