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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

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Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

16,001–16,050 of 31,435, by identifier

6-methylsalicylate + H(+) = 3-methylphenol + CO2
Direction not assertedBalancedRhea 23112
4-hydroxybenzoate + ATP + CoA = 4-hydroxybenzoyl-CoA + AMP + diphosphate
Direction not assertedBalancedRhea 23116
a dipeptide(out) + ATP + H2O = a dipeptide(in) + ADP + phosphate + H(+)
Direction not assertedBalance undeterminableTransportRhea 23120
2 (2R)-3-phosphoglycerate + 2 H(+) = D-ribulose 1,5-bisphosphate + CO2 + H2O
Direction not assertedBalancedRhea 23124
4-hydroxybutanoate + ATP + CoA = 4-hydroxybutanoyl-CoA + AMP + diphosphate
Direction not assertedBalancedRhea 23128
hydrogen sulfide + 6 oxidized [2Fe-2S]-[ferredoxin] + 3 H2O = sulfite + 6 reduced [2Fe-2S]-[ferredoxin] + 7 H(+)
Direction not assertedBalance undeterminableRhea 23132
a primary amine + S-adenosyl-L-methionine = a methylated primary amine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 23136

beta-nicotinamide D-ribonucleotide + H2O = D-ribose 5-phosphate + nicotinamide + H(+)

Direction not assertedBalancedRhea 23140

N-acetyl-alpha-D-glucosamine + NAD(+) + H2O = N-acetyl-D-glucosaminate + NADH + 2 H(+)

Direction not assertedBalancedRhea 23144

propanoate + ATP = propanoyl phosphate + ADP

Direction not assertedBalancedRhea 23148

a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)

Direction not assertedBalance undeterminableRhea 23152

(E)-(indol-3-yl)acetaldehyde oxime = (indol-3-yl)acetonitrile + H2O

Direction not assertedBalancedRhea 23156

L-rhamnopyranose = L-rhamnulose

Direction not assertedBalancedRhea 23160

a 7-O-hydroxy-flavonol + UDP-alpha-D-glucose = a flavonol 7-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalance undeterminableRhea 23164

coformycin + NADP(+) = 8-oxocoformycin + NADPH + H(+)

Direction not assertedBalancedRhea 23168

L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] + ATP = O-phospho-L-seryl-[3-hydroxy-3-methylglutaryl-coenzyme A reductase] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 23172

acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 23176

a secondary alcohol + O2 = a ketone + H2O2

Direction not assertedBalance undeterminableRhea 23180

(6aS,11aS)-3,6a,9-trihydroxypterocarpan + dimethylallyl diphosphate = (6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + diphosphate

Direction not assertedBalancedRhea 23184

propane-1,3-diol + NAD(+) = 3-hydroxypropanal + NADH + H(+)

Direction not assertedBalancedRhea 23188

Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP + H(+)

Direction not assertedBalancedRhea 23192

L-2-aminoadipate + L-valine + L-cysteine + 3 ATP + H2O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 3 H(+)

Direction not assertedBalancedRhea 23196

N(6)-methyl-L-lysine + O2 + H2O = L-lysine + formaldehyde + H2O2

Direction not assertedBalancedRhea 23200

chlorogenate + D-glucarate = 2-O-caffeoylglucarate + L-quinate

Direction not assertedBalancedRhea 23204

trans-glutaconate + acetyl-CoA = (2E)-glutaconyl-CoA + acetate

Direction not assertedBalancedRhea 23208

N-acetyl-beta-alanine + H2O = beta-alanine + acetate

Direction not assertedBalancedRhea 23212

benzoyl-CoA + NADPH + O2 + H(+) = 3-hydroxybenzoyl-CoA + NADP(+) + H2O

Direction not assertedBalancedRhea 23216

4-chlorobenzoate + ATP + CoA = 4-chlorobenzoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 23220

trans-zeatin + UDP-alpha-D-glucose = O-beta-D-glucosyl-trans-zeatin + UDP + H(+)

Direction not assertedBalancedRhea 23224

L-lysine + NADPH + O2 = N(6)-hydroxy-L-lysine + NADP(+) + H2O

Direction not assertedBalancedRhea 23228

hydrazine + 4 Fe(III)-[cytochrome c] = N2 + 4 Fe(II)-[cytochrome c] + 4 H(+)

Direction not assertedBalance undeterminableRhea 23232

[protein]-L-glutamate 5-O-methyl ester + H2O = L-glutamyl-[protein] + methanol + H(+)

Direction not assertedBalance undeterminableRhea 23236

(6S)-5-formyl-5,6,7,8-tetrahydrofolate + L-glutamate = N-formyl-L-glutamate + (6S)-5,6,7,8-tetrahydrofolate + H(+)

Direction not assertedBalancedRhea 23240

S-adenosyl 3-(methylsulfanyl)propylamine + propane-1,3-diamine = norspermidine + S-methyl-5'-thioadenosine + H(+)

Direction not assertedBalancedRhea 23244

myo-inositol + S-adenosyl-L-methionine = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 23248

a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol

Direction not assertedBalance undeterminableRhea 23252

adenosylcob(III)yrinate a,c-diamide + 4 L-glutamine + 4 ATP + 4 H2O = adenosylcob(III)yrate + 4 L-glutamate + 4 ADP + 4 phosphate + 4 H(+)

Direction not assertedBalancedRhea 23256

(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NAD(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADH + H(+)

Left to rightBalancedRhea 23260

(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADP(+) = 15-oxo-(5Z,8Z,11Z,13E)-eicosatetraenoate + NADPH + H(+)

Direction not assertedBalancedRhea 23264

guanidinoacetate + H2O = urea + glycine

Direction not assertedBalancedRhea 23268

an N(6)-alkylaminopurine + UDP-alpha-D-glucose = an N(6)-alkylamino-7-beta-D-glucosylpurine + UDP + H(+)

Direction not assertedBalance undeterminableRhea 23272

2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde

Direction not assertedBalancedRhea 23276

cysteamine + acetyl-CoA = S-acetylcysteamine + CoA

Direction not assertedBalancedRhea 23280

isopentenyl diphosphate = dimethylallyl diphosphate

Direction not assertedBalancedRhea 23284

acetaldehyde + NAD(+) + CoA = acetyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 23288

L-lombricine + ATP = N-phospho-L-lombricine + ADP + H(+)

Direction not assertedBalancedRhea 23292

aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

Direction not assertedBalancedRhea 23296

isopentenyl diphosphate + (2E)-geranyl diphosphate = (2Z,6E)-farnesyl diphosphate + diphosphate

Direction not assertedBalancedRhea 23300

atropine + H2O = tropate + tropine + H(+)

Direction not assertedBalancedRhea 23304

D-glucarate + (E)-sinapoyl-CoA = 2-O-[(E)-sinapoyl]-D-glucarate + CoA

Direction not assertedBalancedRhea 23308

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