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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

15,901–15,950 of 31,435, by identifier

ricinine + 2 H2O = 4-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-3-carboxylate + NH4(+)
Direction not assertedBalancedRhea 22704
an S-acylglutathione + H2O = a carboxylate + glutathione + H(+)
Direction not assertedBalance undeterminableRhea 22708
adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate
Direction not assertedBalancedRhea 22712
cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Left to rightBalance undeterminableRhea 22716
L-histidyl-[protein] + ATP = N(pros)-phospho-L-histidyl-[protein] + ADP + H(+)
Direction not assertedBalance undeterminableRhea 22720
a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)
Left to rightBalance undeterminableRhea 22724

L-seryl-tRNA(Sec) + selenophosphate + H(+) = L-selenocysteinyl-tRNA(Sec) + phosphate

Direction not assertedBalancedRhea 22728

4-hydroxyphenylacetate + H(+) = 4-methylphenol + CO2

Direction not assertedBalancedRhea 22732

5-formimidoyltetrahydrofolate + 2 H(+) = (6R)-5,10-methenyltetrahydrofolate + NH4(+)

Left to rightBalancedRhea 22736

a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)

Left to rightBalancedRhea 22740

a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyladenosine) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(N(6),2'-O-dimethyladenosine) in mRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 22744

4-hydroxy-4-methyl-2-oxoglutarate = 2 pyruvate

Direction not assertedBalancedRhea 22748

uracil + A + H2O = barbiturate + AH2 + H(+)

Direction not assertedBalancedRhea 22752

a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2

Direction not assertedBalance undeterminableRhea 22756

Cypridina luciferin + O2 = oxidized Cypridina luciferin + hnu + CO2

Direction not assertedBalance undeterminableRhea 22760

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate

Left to rightBalance undeterminableRhea 22764

4-nitrophenyl-3-ketovalidamine = 5D-(5/6)-5-C-(hydroxymethyl)-2,6-dihydroxycyclohex-2-en-1-one + 4-nitroaniline

Direction not assertedBalancedRhea 22768

L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O

Direction not assertedBalancedRhea 22772

2 Mn(2+) + H2O2 + 2 H(+) = 2 Mn(3+) + 2 H2O

Direction not assertedBalancedRhea 22776

(9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate

Left to rightBalancedRhea 22780

(2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite + H(+)

Direction not assertedBalancedRhea 22784

dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + L-methionine + H(+)

Direction not assertedBalancedRhea 22788

isonocardicin A = nocardicin A

Direction not assertedBalancedRhea 22792

D-hamamelose + ATP = D-hamamelose 2'-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 22796

cycloeucalenol = obtusifoliol

Direction not assertedBalancedRhea 22800

(6S,9R)-vomifoliol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + NADH + H(+)

Direction not assertedBalancedRhea 22804

6-hydroxynicotinate + O2 + H2O = 2,6-dihydroxynicotinate + H2O2

Direction not assertedBalancedRhea 22808

(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methenyltetrahydrofolate + NADPH

Left to rightBalancedRhea 22812

alpha-D-xylose = alpha-D-xylulofuranose

Direction not assertedBalancedRhea 22816

3-O-[alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP-alpha-D-xylose = 3-O-[alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl]-L-seryl-[EGF-like domain protein] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 22820

2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil

Left to rightBalancedRhea 22824

1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 22828

N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH4(+)

Direction not assertedBalancedRhea 22832

a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2

Left to rightBalance undeterminableRhea 22836

D-glutamine + H2O = D-glutamate + NH4(+)

Direction not assertedBalancedRhea 22840

(6aS,11aS)-4-dimethylallyl-3,6a,9-trihydroxypterocarpan + reduced [NADPH--hemoprotein reductase] + O2 = glyceollin I + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 22844

(3S)-hydroxyoctanedioyl-CoA + NAD(+) = 3-oxooctanedioyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 22848

L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

Left to rightBalancedRhea 22852

(7S)-salutaridinol + acetyl-CoA = (7S)-O-acetylsalutaridinol + CoA

Direction not assertedBalancedRhea 22856

nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate

ReversibleBalancedRhea 22860

L-lysine = D-lysine

Direction not assertedBalancedRhea 22864

thioglycolate + 3-chloro-L-alanine = S-carboxymethyl-L-cysteine + chloride + H(+)

Direction not assertedBalancedRhea 22868

L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-3-hydroxy-L-prolyl-[collagen] + succinate + CO2

Left to rightBalance undeterminableRhea 22872

(R)-mandelamide + H2O = (R)-mandelate + NH4(+)

Direction not assertedBalancedRhea 22876

L-arogenate + 2-oxoglutarate = prephenate + L-glutamate

Direction not assertedBalancedRhea 22880

glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

Direction not assertedBalancedRhea 22884

(R)-methylmalonyl-CoA = succinyl-CoA

Left to rightBalancedRhea 22888

(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methenyltetrahydrofolate + NADH

Direction not assertedBalancedRhea 22892

n malonyl-CoA + acetyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acyl-CoA + n CO2 + 2n NADP(+) + n CoA + H2O

Direction not assertedBalance undeterminableRhea 22896

(R)-acetoin + NAD(+) = diacetyl + NADH + H(+)

Direction not assertedBalancedRhea 22900

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