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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

15,751–15,800 of 31,435, by identifier

quinolin-2-ol + NADH + O2 + H(+) = quinoline-2,8-diol + NAD(+) + H2O
Direction not assertedBalancedRhea 22080
(S)-2,3-diaminopropanoate + H2O + H(+) = pyruvate + 2 NH4(+)
Direction not assertedBalancedRhea 22084
GTP + ATP = guanosine 3'-diphosphate 5'-triphosphate + AMP
Direction not assertedBalancedRhea 22088
(3Z)-phycoerythrobilin + oxidized 2[4Fe-4S]-[ferredoxin] = 15,16-dihydrobiliverdin + reduced 2[4Fe-4S]-[ferredoxin] + 2 H(+)
Direction not assertedBalance undeterminableRhea 22092
RNA(n+1) + phosphate = RNA(n) + a ribonucleoside 5'-diphosphate
Left to rightBalance undeterminableRhea 22096
3,5-dibromo-4-hydroxybenzonitrile + 2 H2O = 3,5-dibromo-4-hydroxybenzoate + NH4(+)
Direction not assertedBalancedRhea 22100
nicotianamine + 2-oxoglutarate = 3''-deamino-3''-oxonicotianamine + L-glutamate

Direction not assertedBalancedRhea 22104

L-threonine = 2-oxobutanoate + NH4(+)

Direction not assertedBalancedRhea 22108

isoxazolin-5-one + O-acetyl-L-serine = 3-(5-oxoisoxazolin-2-yl)-L-alanine + acetate + H(+)

Direction not assertedBalancedRhea 22112

luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] + UDP-alpha-D-glucuronate = luteolin 7-O-[(beta-D-glucuronosyl)-(1->2)-(beta-D-glucuronide)] 4'-O-beta-D-glucuronide + UDP + H(+)

Direction not assertedBalancedRhea 22116

GTP + succinate + CoA = succinyl-CoA + GDP + phosphate

Direction not assertedBalancedRhea 22120

17-O-acetylajmaline + H2O = ajmaline + acetate + H(+)

Direction not assertedBalancedRhea 22124

(1S,2R,4S)-borneol + NAD(+) = (1S,4S)-camphor + NADH + H(+)

Direction not assertedBalancedRhea 22128

D-maltose(out) + ATP + H2O = D-maltose(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 22132

7(1)-hydroxychlorophyllide a + NADPH + O2 + H(+) = chlorophyllide b + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 22136

a nucleoside 5'-phosphate + H2O = a nucleoside + phosphate

Direction not assertedBalance undeterminableRhea 22140

cis-aconitate + H2O = D-threo-isocitrate

Direction not assertedBalancedRhea 22144

2 oxidized [plastocyanin] + a plastoquinol + 2 H(+)(in) = 2 reduced [plastocyanin] + a plastoquinone + 4 H(+)(out)

Direction not assertedBalance undeterminableTransportRhea 22148

a ubiquinone + D-glucose = D-glucono-1,5-lactone + a ubiquinol

Direction not assertedBalance undeterminableRhea 22152

GDP + H2O = GMP + phosphate + H(+)

Left to rightBalancedRhea 22156

a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside + 4-coumaroyl-CoA = a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] + CoA

Direction not assertedBalance undeterminableRhea 22160

a globoside Gb4Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a globoside Forssman (d18:1(4E)) + UDP + H(+)

Direction not assertedBalance undeterminableRhea 22164

UDP-alpha-D-glucose = UDP-alpha-D-galactose

Direction not assertedBalancedRhea 22168

beta-D-fructose 6-phosphate + UDP-alpha-D-glucose = sucrose 6(F)-phosphate + UDP + H(+)

Direction not assertedBalancedRhea 22172

leukotriene B4 + reduced [NADPH--hemoprotein reductase] + O2 = 20-hydroxy-leukotriene B4 + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 22176

(S)-norreticuline + S-adenosyl-L-methionine = (S)-norcodamine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 22180

(+-)-trans-acenaphthene-1,2-diol + 2 NADP(+) = acenaphthene-1,2-dione + 2 NADPH + 2 H(+)

Direction not assertedBalancedRhea 22184

an (R)-2-haloacid + H2O = a (2S)-2-hydroxycarboxylate + a halide anion + H(+)

Direction not assertedBalance undeterminableRhea 22188

(6R)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + (6S)-5,6,7,8-tetrahydrofolate

Left to rightBalancedRhea 22192

trans-aconitate + S-adenosyl-L-methionine = (E)-2-(methoxycarbonylmethyl)but-2-enedioate + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 22200

3-hydroxyphenylacetate + NADPH + O2 + H(+) = homogentisate + NADP(+) + H2O

Direction not assertedBalancedRhea 22204

3-hydroxyphenylacetate + NADH + O2 + H(+) = homogentisate + NAD(+) + H2O

Direction not assertedBalancedRhea 22208

(2R,3R)-tartrate = (2R,3S)-tartrate

Direction not assertedBalancedRhea 22212

(E)-caffeate + O2 = 3-(2-carboxyethenyl)-cis,cis-muconate + 2 H(+)

Direction not assertedBalancedRhea 22216

ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate

Direction not assertedBalancedRhea 22220

N-methylanthraniloyl-CoA + 3 malonyl-CoA + 3 H(+) = 1,3-dihydroxy-N-methylacridone + 3 CO2 + 4 CoA + H2O

Direction not assertedBalancedRhea 22224

presqualene diphosphate + NADH + H(+) = squalene + diphosphate + NAD(+)

Left to rightBalancedRhea 22228

presqualene diphosphate + NADPH + H(+) = squalene + diphosphate + NADP(+)

Left to rightBalancedRhea 22232

2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate

Direction not assertedBalancedRhea 22236

methylenediurea + H2O = N-(carboxyaminomethyl)urea + NH4(+)

Direction not assertedBalancedRhea 22240

kaempferol + UDP-alpha-D-xylose = kaempferol 3-O-beta-D-xyloside + UDP + H(+)

Direction not assertedBalancedRhea 22244

7,8-dihydro-7,8-dihydroxykynurenate + NAD(+) = 7,8-dihydroxykynurenate + NADH + H(+)

Direction not assertedBalancedRhea 22248

a globoside Gb3Cer (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a globoside Gb4Cer (d18:1(4E)) + UDP + H(+)

Left to rightBalance undeterminableRhea 22252

a (3R)-3-hydroxyacyl-CoA + NADP(+) = a 3-oxoacyl-CoA + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 22256

triacetate lactone + H2O = 3,5-dioxohexanoate + H(+)

Direction not assertedBalancedRhea 22260

3,5,6-trichloropyridin-2-ol + FADH2 + O2 = 3,6-dichloropyridine-2,5-dione + FAD + chloride + H2O + 2 H(+)

Direction not assertedBalancedRhea 22264

streptomycin + ATP = streptomycin 6-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 22268

(20S)-protopanaxadiol + reduced [NADPH--hemoprotein reductase] + O2 = (20S)-protopanaxatriol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 22272

2-oxoaldehyde + NAD(+) + H2O = a 2-oxocarboxylate + NADH + 2 H(+)

Direction not assertedBalance undeterminableRhea 22276

O-demethylpuromycin + S-adenosyl-L-methionine = puromycin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 22280

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