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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

15,601–15,650 of 31,435, by identifier

a [peptide]-C-terminal glycine + 2 L-ascorbate + O2 = a [peptide]-C-terminal (2S)-2-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
Direction not assertedBalance undeterminableRhea 21452
(S)-tetrahydrocolumbamine + reduced [NADPH--hemoprotein reductase] + O2 = (S)-canadine + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)
Direction not assertedBalance undeterminableRhea 21456
benzoin = 2 benzaldehyde
Direction not assertedBalancedRhea 21460
thiocyanate + H2O + 2 H(+) = carbonyl sulfide + NH4(+)
Direction not assertedBalancedRhea 21464
tylactone + dTDP-alpha-D-mycaminose = 5-O-beta-D-mycaminosyltylactone + dTDP + H(+)
Direction not assertedBalancedRhea 21468
citrate + ATP + CoA = (3S)-citryl-CoA + ADP + phosphate
Direction not assertedBalancedRhea 21472

[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-beta-D-glucosyl](n+1) + UDP + H(+)

Direction not assertedBalance undeterminableRhea 21476

2-furoyl-CoA + A + H2O = 5-hydroxy-2-furoyl-CoA + AH2 + H(+)

Direction not assertedBalancedRhea 21480

dalnigrein beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranoside + H2O = dalnigrein + beta-D-apiofuranosyl-(1->6)-D-glucopyranose + H(+)

Direction not assertedBalancedRhea 21488

2,3-dihydroxybenzoate + H(+) = catechol + CO2

Direction not assertedBalancedRhea 21492

dimethylallyl diphosphate + H2O = prenol + diphosphate

Direction not assertedBalancedRhea 21496

UDP-alpha-D-glucose = UDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O

Left to rightBalancedRhea 21500

aldehydo-D-ribose 5-phosphate + acetoin = 1-deoxy-D-altro-heptulose 7-phosphate + acetaldehyde

Direction not assertedBalancedRhea 21504

all-trans-retinyl hexadecanoate + H2O = retinol + hexadecanoate + H(+)

Direction not assertedBalancedRhea 21508

3,6-anhydro-L-galactonate = 2-dehydro-3-deoxy-L-galactonate

Direction not assertedBalancedRhea 21512

isopiperitenone = piperitenone

Direction not assertedBalancedRhea 21516

2 Fe(III)-[cytochrome b1] + formate = 2 Fe(II)-[cytochrome b1] + CO2 + H(+)

Direction not assertedBalance undeterminableRhea 21520

3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)

Direction not assertedBalancedRhea 21524

[phosphate](n) + H2O = [phosphate](n-1) + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 21528

glutathionylspermidine + glutathione + ATP = trypanothione + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 21532

(3S)-3-hydroxy-3-methylglutaryl-CoA = 3-methyl-(2E)-glutaconyl-CoA + H2O

Right to leftBalancedRhea 21536

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate

Direction not assertedBalancedRhea 21540

(2E,6E)-farnesyl diphosphate + ATP = (2E,6E)-farnesyl triphosphate + ADP

Left to rightBalancedRhea 21544

N(6)-acetyl-L-lysyl-[alpha-tubulin] + H2O = L-lysyl-[alpha-tubulin] + acetate

Left to rightBalance undeterminableRhea 21548

a beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)-Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + CMP + H(+)

Direction not assertedBalance undeterminableRhea 21552

[calmodulin]-L-lysine + S-adenosyl-L-methionine = [calmodulin]-N(6)-methyl-L-lysine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 21556

3-hydroxy-2-methyl-3-phytyl-2,3-dihydro-1,4-naphthoquinone + oxidized dithiothreitol = 1,4-dithiothreitol + 2,3-epoxyphylloquinone

Direction not assertedBalancedRhea 21560

an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

ReversibleBalance undeterminableRhea 21564

beta-D-Gal-(1->3)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-D-Glc + H2O = beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + lactose

Direction not assertedBalancedRhea 21568

3-hydroxy-2-methyl-1H-quinolin-4-one + O2 = N-acetylanthranilate + CO + H(+)

Direction not assertedBalancedRhea 21572

carnitine + H(+) = 2-methylcholine + CO2

Direction not assertedBalancedRhea 21576

(2S)-2-acetolactate + H(+) = (R)-acetoin + CO2

Direction not assertedBalancedRhea 21580

propane-1,2-diol 1-phosphate + NAD(+) = hydroxyacetone phosphate + NADH + H(+)

Direction not assertedBalancedRhea 21584

N-acetyl-L-glutamate 5-semialdehyde + phosphate + NADP(+) = N-acetyl-L-glutamyl 5-phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 21588

(2S)-2-[(R)-1-carboxyethylamino]pentanoate + NAD(+) + H2O = L-2-aminopentanoate + pyruvate + NADH + H(+)

Direction not assertedBalancedRhea 21592

L-serine + NADP(+) = 2-aminomalonate semialdehyde + NADPH + H(+)

Direction not assertedBalancedRhea 21596

anthranilate + benzoyl-CoA = N-benzoylanthranilate + CoA

Direction not assertedBalancedRhea 21600

styrene oxide = 2-phenylacetaldehyde

Direction not assertedBalancedRhea 21604

isoliquiritigenin + S-adenosyl-L-methionine = 2'-O-methylisoliquiritigenin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 21608

D-gluconate = 2-dehydro-3-deoxy-D-gluconate + H2O

Direction not assertedBalancedRhea 21612

a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)

Left to rightBalance undeterminableRhea 21616

FMNH2 + NAD(+) = FMN + NADH + 2 H(+)

Right to leftBalancedRhea 21620

FMNH2 + NADP(+) = FMN + NADPH + 2 H(+)

Right to leftBalancedRhea 21624

17alpha-hydroxyprogesterone + NADPH + O2 = androst-4-ene-3,17-dione + acetate + NADP(+) + H2O

Direction not assertedBalancedRhea 21628

2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O

Direction not assertedBalancedRhea 21632

(E)-4-coumarate + UDP-alpha-D-glucose = 4-O-(beta-D-glucosyl)-trans-4-coumarate + UDP + H(+)

Direction not assertedBalancedRhea 21636

prephenate + NADP(+) = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH

Direction not assertedBalancedRhea 21640

glycerol + ATP = sn-glycerol 3-phosphate + ADP + H(+)

Left to rightBalancedRhea 21644

prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O

Direction not assertedBalancedRhea 21648

2-chlorobenzoate + NADH + O2 + H(+) = catechol + chloride + CO2 + NAD(+)

Direction not assertedBalancedRhea 21652

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