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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

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Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

15,401–15,450 of 31,435, by identifier

glutaryl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E)-glutaconyl-CoA + reduced [electron-transfer flavoprotein]
Direction not assertedBalance undeterminableRhea 20589
N-acetyl-D-glucosamine + H2O = D-glucosamine + acetate
Direction not assertedBalancedRhea 20593
2 L-cysteine + NAD(+) = L-cystine + NADH + H(+)
Direction not assertedBalancedRhea 20597
cytosine + H2O + H(+) = uracil + NH4(+)
Direction not assertedBalancedRhea 20605
2-dehydro-3-deoxy-D-arabinonate = glycolaldehyde + pyruvate
Direction not assertedBalancedRhea 20609
a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + 3'-phosphoadenylyl sulfate = an N-acyl-1-beta-D-(3-O-sulfo)-galactosyl-sphing-4-enine + adenosine 3',5'-bisphosphate + H(+)
Left to rightBalance undeterminableRhea 20613
L-galactono-1,4-lactone + O2 = L-ascorbate + H2O2 + H(+)

Direction not assertedBalancedRhea 20617

Zn(2+)(in) + ATP + H2O = Zn(2+)(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 20621

2 Fe(III)-[cytochrome c3] + H2 = 2 Fe(II)-[cytochrome c3] + 2 H(+)

Direction not assertedBalance undeterminableRhea 20625

O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate

Left to rightBalance undeterminableRhea 20629

a (3R)-hydroxyacyl-[ACP] + L-ornithine = a lyso-ornithine lipid + holo-[ACP] + H(+)

Direction not assertedBalance undeterminableRhea 20633

D-fructose + D-glucose = D-glucono-1,5-lactone + D-sorbitol

Direction not assertedBalancedRhea 20637

L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)

Direction not assertedBalancedRhea 20641

23,24-dihydrocucurbitacin B + NADP(+) = cucurbitacin B + NADPH + H(+)

Direction not assertedBalancedRhea 20649

23,24-dihydrocucurbitacin B + NAD(+) = cucurbitacin B + NADH + H(+)

Direction not assertedBalancedRhea 20653

4-chlorophenylacetonitrile + 2 H2O = 4-chlorophenylacetate + NH4(+)

Direction not assertedBalancedRhea 20657

D-alanyl-D-alanine + H2O = 2 D-alanine

Direction not assertedBalancedRhea 20661

1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + NADPH + H(+)

Direction not assertedBalancedRhea 20665

4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NAD(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADH

Direction not assertedBalancedRhea 20669

4alpha-carboxy-4beta-methyl-5alpha-cholest-7-ene-3beta-ol + NADP(+) = 4alpha-methyl-5alpha-cholest-7-en-3-one + CO2 + NADPH

Direction not assertedBalancedRhea 20673

alizarin + UDP-alpha-D-glucose = 1-hydroxy-2-(beta-D-glucosyloxy)-9,10-anthraquinone + UDP + H(+)

Direction not assertedBalancedRhea 20677

cis-zeatin + UDP-alpha-D-glucose = O-beta-D-glucosyl-cis-zeatin + UDP + H(+)

Direction not assertedBalancedRhea 20681

galactitol + NAD(+) = keto-D-tagatose + NADH + H(+)

Direction not assertedBalancedRhea 20685

chlorogenate + H2O = L-quinate + (E)-caffeate + H(+)

Direction not assertedBalancedRhea 20689

2 superoxide + 2 H(+) = H2O2 + O2

Left to rightBalancedRhea 20696

lipid A disaccharide (E. coli) + ATP = lipid IVA (E. coli) + ADP + H(+)

Direction not assertedBalancedRhea 20700

a D-alpha-amino acid + acetyl-CoA = an N-acetyl-D-amino acid + CoA + H(+)

Direction not assertedBalance undeterminableRhea 20704

erythritol + ATP = D-erythritol 4-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 20708

6-carboxyhexanoyl-CoA + L-alanine + H(+) = (8S)-8-amino-7-oxononanoate + CO2 + CoA

Direction not assertedBalancedRhea 20712

S-adenosyl-L-homocysteine + H2O + H(+) = S-inosyl-L-homocysteine + NH4(+)

Direction not assertedBalancedRhea 20716

isopenicillin N + phenylacetyl-CoA + H2O = penicillin G + L-2-aminoadipate + CoA + H(+)

Direction not assertedBalancedRhea 20720

a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O

Left to rightBalance undeterminableRhea 20724

L-glutamate + O2 + H2O = 2-oxoglutarate + H2O2 + NH4(+)

Direction not assertedBalancedRhea 20728

[protein]-dithiol + [thioredoxin]-disulfide = [protein]-disulfide + [thioredoxin]-dithiol

Direction not assertedBalance undeterminableRhea 20732

glycine + acetyl-CoA = (2S)-2-amino-3-oxobutanoate + CoA

Right to leftBalancedRhea 20736

trans-2,3-epoxysuccinate + H2O = (2R,3S)-tartrate

Direction not assertedBalancedRhea 20740

prostaglandin D2 + NADP(+) = 15-oxoprostaglandin D2 + NADPH + H(+)

Left to rightBalancedRhea 20744

penicillin N + 2-oxoglutarate + O2 = deacetoxycephalosporin C + succinate + CO2 + H2O

Direction not assertedBalancedRhea 20748

2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

Right to leftBalancedRhea 20752

D-threo-isocitrate + (E)-caffeoyl-CoA = 2-[(E)-caffeoyl]-D-threo-isocitrate(3-) + CoA

Direction not assertedBalancedRhea 20756

(S)-methylmalonyl-CoA + pyruvate = propanoyl-CoA + oxaloacetate

Direction not assertedBalancedRhea 20764

3-phosphonopyruvate + H(+) = phosphonoacetaldehyde + CO2

Direction not assertedBalancedRhea 20768

2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin

Direction not assertedBalancedRhea 20772

alpha-D-galactosyl-(1->3)-1D-myo-inositol + raffinose = stachyose + myo-inositol

Direction not assertedBalancedRhea 20776

GMP + ATP = GDP + ADP

Direction not assertedBalancedRhea 20780

N(omega)-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + L-arginine

Direction not assertedBalancedRhea 20784

phosphate + NAD(+) = ADP-alpha-D-ribose 1''-phosphate + nicotinamide + H(+)

Direction not assertedBalancedRhea 20788

tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate

Direction not assertedBalancedRhea 20792

aldehydo-D-ribose = D-ribulose

Direction not assertedBalancedRhea 20796

3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine = 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP + H(+)

Left to rightBalance undeterminableRhea 20800

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