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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

15,351–15,400 of 31,435, by identifier

androsterone + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)
ReversibleBalancedRhea 20381
(2R,3R)-dihydroquercetin + NADH + O2 + H(+) = (2R,3R)-2,3-dihydrogossypetin + NAD(+) + H2O
Direction not assertedBalancedRhea 20385
(2R,3R)-dihydroquercetin + NADPH + O2 + H(+) = (2R,3R)-2,3-dihydrogossypetin + NADP(+) + H2O
Direction not assertedBalancedRhea 20389
S-acetylphosphopantotheine + holo-[citrate lyase ACP] = acetyl-[citrate lyase ACP] + (R)-4'-phosphopantetheine
Direction not assertedBalance undeterminableRhea 20393
O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)
Direction not assertedBalancedRhea 20397
a beta-lactam + H2O = a substituted beta-amino acid
Direction not assertedBalance undeterminableRhea 20401
N-acetyl-(2S,6S)-2,6-diaminopimelate + H2O = (2S,6S)-2,6-diaminopimelate + acetate

Direction not assertedBalancedRhea 20405

riboflavin + alpha-D-glucose 1-phosphate = FMN + D-glucose

Direction not assertedBalancedRhea 20409

glucuronoxylan D-glucuronate + n S-adenosyl-L-methionine = glucuronoxylan 4-O-methyl-D-glucuronate + n S-adenosyl-L-homocysteine + n H(+)

Direction not assertedBalance undeterminableRhea 20413

coelenterazine + O2 = coelenteramide + hnu + CO2

Direction not assertedBalance undeterminableRhea 20417

alpha-maltose 6'-phosphate + H2O = D-glucose 6-phosphate + D-glucose

Direction not assertedBalancedRhea 20421

hydrogencarbonate + 2-oxoglutarate + ATP = (S)-oxalosuccinate + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 20425

apigenin + S-adenosyl-L-methionine = acacetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 20429

xylitol + NAD(+) = D-xylulose + NADH + H(+)

Direction not assertedBalancedRhea 20433

5D-5-O-methyl-chiro-inositol + NADP(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADPH + H(+)

Direction not assertedBalancedRhea 20437

L-cysteine + O2 = 3-sulfino-L-alanine + H(+)

Left to rightBalancedRhea 20441

L-arogenate + oxaloacetate = prephenate + L-aspartate

Direction not assertedBalancedRhea 20445

5-amino-4-chloro-2-(2,3-dihydroxyphenyl)pyridazin-3(2H)-one + O2 = 5-amino-4-chloro-2-(2-hydroxymuconoyl)pyridazin-3(2H)-one + 2 H(+)

Direction not assertedBalancedRhea 20449

scopoletin + UDP-alpha-D-glucose = scopolin + UDP + H(+)

Direction not assertedBalancedRhea 20453

D-arabinose + NAD(+) = D-arabinono-1,4-lactone + NADH + H(+)

Direction not assertedBalancedRhea 20457

an N(2)-[(3R)-3-(2-saturated-acyloxy)acyl]-L-ornithine lipid + 3 S-adenosyl-L-methionine = an N,N,N-trimethylornithine lipid + 3 S-adenosyl-L-homocysteine + 3 H(+)

Direction not assertedBalance undeterminableRhea 20461

[hyaluronan](n) + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-beta-D-glucosaminyl-(1->4)-[hyaluronan](n) + UDP + H(+)

Left to rightBalance undeterminableRhea 20465

IMP + H2O = hypoxanthine + D-ribose 5-phosphate

Direction not assertedBalancedRhea 20469

(R)-lipoyl-5'-AMP + L-lysyl-[lipoyl-carrier protein] = N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein] + AMP + 2 H(+)

Direction not assertedBalance undeterminableRhea 20473

coelenterazine h + 3'-phosphoadenylyl sulfate = luciferyl sulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 20481

(S)-scoulerine + reduced [NADPH--hemoprotein reductase] + O2 = (S)-cheilanthifoline + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 20485

L-alanyl-tRNA(Ala) + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = a 1,2-diacyl-sn-glycero-3-phospho-1'-(3'-O-L-alanyl)-sn-glycerol + tRNA(Ala)

Direction not assertedBalance undeterminableRhea 20489

an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)

Direction not assertedBalance undeterminableRhea 20493

a 2-arylethylamine + acetyl-CoA = an N-acetyl-2-arylethylamine + CoA + H(+)

Direction not assertedBalance undeterminableRhea 20497

an alpha-(gamma-L-glutamyl)-L-amino acid = 5-oxo-L-proline + an L-alpha-amino acid

Left to rightBalance undeterminableRhea 20505

viomycin + ATP = O-phosphoviomycin + ADP + H(+)

Direction not assertedBalancedRhea 20509

2-aryl-2-methylmalonate + H(+) = 2-arylpropionate + CO2

Direction not assertedBalance undeterminableRhea 20513

UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-galactosamine

Direction not assertedBalancedRhea 20517

(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + NADH + H(+)

Direction not assertedBalancedRhea 20521

ethylamine + L-glutamate + ATP = N(5)-ethyl-L-glutamine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 20525

2-cis-(+)-abscisic aldehyde + O2 + H2O = 2-cis-(+)-abscisate + H2O2 + H(+)

Direction not assertedBalancedRhea 20529

pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate

Left to rightBalancedRhea 20533

holo-[ACP] + H2O = apo-[ACP] + (R)-4'-phosphopantetheine + H(+)

Direction not assertedBalance undeterminableRhea 20537

Mg-13(1)-hydroxyprotoporphyrin 13-monomethyl ester + NADPH + O2 + H(+) = Mg-13(1)-oxoprotoporphyrin 13-monomethyl ester + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 20541

L-kynurenine + NADPH + O2 + H(+) = 3-hydroxy-L-kynurenine + NADP(+) + H2O

Direction not assertedBalancedRhea 20545

2 thiosulfate + 2 Fe(III)-[cytochrome c] = tetrathionate + 2 Fe(II)-[cytochrome c] + 2 H(+)

Direction not assertedBalance undeterminableRhea 20549

(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA

Right to leftBalancedRhea 20553

urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)

Direction not assertedBalancedRhea 20557

3-hydroxypyruvate + H(+) = glycolaldehyde + CO2

Direction not assertedBalancedRhea 20561

(2E)-geranyl diphosphate + H2O = (1S,2S,4R)-endo-fenchol + diphosphate

Direction not assertedBalancedRhea 20565

L-arginine + H2O = urea + L-ornithine

Left to rightBalancedRhea 20569

calcidiol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = calcitriol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 20573

3-hydroxyaminophenol = aminohydroquinone

Direction not assertedBalancedRhea 20577

NH4(+) + NAD(+) + H2O = hydroxylamine + NADH + 2 H(+)

Direction not assertedBalancedRhea 20581

loganin + reduced [NADPH--hemoprotein reductase] + O2 = secologanin + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 20585

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