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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

15,301–15,350 of 31,435, by identifier

alpha-D-mannose derivative + UDP-alpha-D-glucose = 6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + UMP + H(+)
Direction not assertedBalance undeterminableRhea 20181
a CMP-N-acyl-beta-neuraminate + H2O = an N-acylneuraminate + CMP + H(+)
Direction not assertedBalance undeterminableRhea 20185
5,6-dihydrouracil + NAD(+) = uracil + NADH + H(+)
Direction not assertedBalancedRhea 20189
(R)-mevalonate + NADP(+) = (R)-mevaldate + NADPH + H(+)
Direction not assertedBalancedRhea 20193
[heparosan-N-sulfate](n) = [heparan-N-sulfate](n)
Direction not assertedBalance undeterminableRhea 20197
L-phenylalanine + ATP + H2O = D-phenylalanine + AMP + diphosphate + H(+)
Direction not assertedBalancedRhea 20201
methylazoxymethanol + UDP-alpha-D-glucose = cycasin + UDP + H(+)

Direction not assertedBalancedRhea 20205

xylitol + ATP = xylitol 5-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 20209

N(6)-octanoyl-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] = N(6)-octanoyl-L-lysyl-[lipoyl-carrier protein] + L-lysyl-[glycine-cleavage complex H protein]

Direction not assertedBalance undeterminableRhea 20213

trimethylamine N-oxide + H(+) = dimethylamine + formaldehyde

Direction not assertedBalancedRhea 20217

(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate

Left to rightBalancedRhea 20221

(E)-caffeate + S-adenosyl-L-methionine = (E)-ferulate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 20225

2,3-dihydroxybenzoate + ATP + H(+) = 2,3-dihydroxybenzoyl-5'-AMP + diphosphate

Direction not assertedBalancedRhea 20229

a 7beta-hydroxysteroid + NADP(+) = a 7-oxosteroid + NADPH + H(+)

Right to leftBalance undeterminableRhea 20233

(1S,4S)-5-oxo-1,2-campholide = [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-en-1-yl]acetate + H(+)

Direction not assertedBalancedRhea 20237

nicotinate + S-adenosyl-L-methionine = N-methylnicotinate + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 20241

streptomycin + ATP = 3''-O-adenylylstreptomycin + diphosphate

Direction not assertedBalancedRhea 20245

L-alanine = D-alanine

Direction not assertedBalancedRhea 20249

(2R,3S)-2,3-dimethylmalate = dimethylmaleate + H2O

Direction not assertedBalancedRhea 20253

3-methyloxindole + NADP(+) = 3-methyleneoxindole + NADPH + H(+)

Direction not assertedBalancedRhea 20257

3,5,7-trioxododecanoyl-CoA = olivetol + CO2 + CoA

Direction not assertedBalancedRhea 20261

L-proline + 2-oxoglutarate + O2 = cis-3-hydroxy-L-proline + succinate + CO2

Direction not assertedBalancedRhea 20265

4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate = 2 5-dehydro-4-deoxy-D-glucuronate

Direction not assertedBalancedRhea 20269

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine

Direction not assertedBalancedRhea 20273

an N-hydroxyarylamine + acetyl-CoA = an N-acetoxyarylamine + CoA

Direction not assertedBalance undeterminableRhea 20277

(Z)-desulfoglucotropeolin + 3'-phosphoadenylyl sulfate = (Z)-glucotropeolin + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 20281

beta-D-galactosyl-(1->3)-N-acetyl-D-glucosamine + phosphate = alpha-D-galactose 1-phosphate + N-acetyl-D-glucosamine

Direction not assertedBalancedRhea 20285

acetyl-CoA + H2O = acetate + CoA + H(+)

Left to rightBalancedRhea 20289

3-(3,5-diiodo-4-hydroxyphenyl)lactate + NAD(+) = 3-(3,5-diiodo-4-hydroxyphenyl)pyruvate + NADH + H(+)

Direction not assertedBalancedRhea 20293

an anilide + H2O = aniline + a carboxylate + H(+)

Direction not assertedBalance undeterminableRhea 20297

tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate

Direction not assertedBalancedRhea 20301

4-hydroxybenzaldehyde + NAD(+) + H2O = 4-hydroxybenzoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 20305

2 H2O2 = O2 + 2 H2O

Direction not assertedBalancedRhea 20309

1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ATP = 1D-myo-inositol hexakisphosphate + ADP + H(+)

Direction not assertedBalancedRhea 20313

L-proline + NADP(+) = 1-pyrroline-2-carboxylate + NADPH + H(+)

Right to leftBalancedRhea 20317

L-proline + NAD(+) = 1-pyrroline-2-carboxylate + NADH + H(+)

Right to leftBalancedRhea 20321

N-hydroxy-4-acetylaminobiphenyl = N-acetoxy-4-aminobiphenyl

Direction not assertedBalancedRhea 20325

L-seryl-[low-density-lipoprotein receptor] + ATP = O-phospho-L-seryl-[low-density-lipoprotein receptor] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 20329

L-seryl-[acetyl-CoA carboxylase] + ATP = O-phospho-L-seryl-[acetyl-CoA carboxylase] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 20333

(R)-2-O-sulfolactate + H2O = (R)-lactate + sulfate + H(+)

Direction not assertedBalancedRhea 20337

sn-glycerol 3-phosphate + UDP-alpha-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + UDP + H(+)

Direction not assertedBalancedRhea 20341

[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide + NADPH + H(+)

Right to leftBalance undeterminableRhea 20345

toluene + NADH + O2 + H(+) = 2-hydroxytoluene + NAD(+) + H2O

Direction not assertedBalancedRhea 20349

trichloroethene + chloride + A + H(+) = tetrachloroethene + AH2

Direction not assertedBalancedRhea 20353

3-phenylpropanoate + NADH + O2 + H(+) = 3-(cis-5,6-dihydroxycyclohexa-1,3-dien-1-yl)propanoate + NAD(+)

Direction not assertedBalancedRhea 20357

4-hydroxy-3-(all-trans-hexaprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 3,4-dihydroxy-5-(all-trans-hexaprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 20361

phosphoethanolamine + S-adenosyl-L-methionine = N-methylethanolamine phosphate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 20365

betaine aldehyde + O2 + H2O = glycine betaine + H2O2 + H(+)

Direction not assertedBalancedRhea 20369

propanoate + ATP + CoA = propanoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 20373

androsterone + NADP(+) = 5alpha-androstan-3,17-dione + NADPH + H(+)

Right to leftBalancedRhea 20377

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