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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Articles

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Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

15,151–15,200 of 31,435, by identifier

L-tryptophan + H2O = indole + pyruvate + NH4(+)
Direction not assertedBalancedRhea 19553
pregna-4,9(11)-diene-3,20-dione + AH2 + O2 = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H2O
Direction not assertedBalancedRhea 19557
androst-4-ene-3,17-dione + NADPH + O2 + H(+) = testololactone + NADP(+) + H2O
Direction not assertedBalancedRhea 19561
(2E)-geranyl diphosphate + H2O = sabinene hydrate + diphosphate
Direction not assertedBalancedRhea 19565
5-aminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-methionine = 5-methylaminomethyl-2-thiouridine(34) in tRNA + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 19569
[phosphate](n) + ATP = [phosphate](n+1) + ADP
Direction not assertedBalance undeterminableRhea 19573
luteolin + UDP-alpha-D-glucose = luteolin 7-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 19577

N(6)-dimethylallyladenine + S-adenosyl-L-methionine = discadenine + S-methyl-5'-thioadenosine + H(+)

Direction not assertedBalancedRhea 19581

lithocholate + NAD(+) = 3-oxo-5beta-cholan-24-oate + NADH + H(+)

Direction not assertedBalancedRhea 19585

L-arginine + H2O = L-citrulline + NH4(+)

Direction not assertedBalancedRhea 19597

orcinol + NADH + O2 + H(+) = 2,3,5-trihydroxytoluene + NAD(+) + H2O

Direction not assertedBalancedRhea 19601

a chlorophyll + H2O = a chlorophyllide + phytol + H(+)

Direction not assertedBalance undeterminableRhea 19605

adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)

Direction not assertedUnbalancedRhea 19609

dimethyl sulfide + S-adenosyl-L-methionine = trimethylsulfonium + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 19613

a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(purine-ribonucleoside) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 19617

a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 3'-phosphate + H(+)

Direction not assertedBalance undeterminableRhea 19621

L-threonine = acetaldehyde + glycine

Left to rightBalancedRhea 19625

D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH

Left to rightBalancedRhea 19629

(3S,5S)-3,5-diaminohexanoate + NAD(+) + H2O = (5S)-5-amino-3-oxohexanoate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 19633

D-nopaline + NADP(+) + H2O = L-arginine + 2-oxoglutarate + NADPH + H(+)

Direction not assertedBalancedRhea 19637

(E)-4-coumarate + ATP + CoA = (E)-4-coumaroyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 19641

a D-threo-aldose + NAD(+) = a D-threo-aldono-1,5-lactone + NADH + H(+)

Direction not assertedBalance undeterminableRhea 19645

tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate

Direction not assertedBalancedRhea 19649

CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NAD(+) + H2O = CDP-4-dehydro-6-deoxy-alpha-D-glucose + NADH + H(+)

Direction not assertedBalancedRhea 19653

CDP-4-dehydro-3,6-dideoxy-alpha-D-glucose + NADP(+) + H2O = CDP-4-dehydro-6-deoxy-alpha-D-glucose + NADPH + H(+)

Direction not assertedBalancedRhea 19657

D-mannitol 1-phosphate + NAD(+) = beta-D-fructose 6-phosphate + NADH + H(+)

Direction not assertedBalancedRhea 19661

6-carboxyhexanoyl-CoA + NAD(+) = 6-carboxyhex-2-enoyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 19665

GTP + H2O = GDP + phosphate + H(+)

Left to rightBalancedRhea 19669

1,2,3-trihydroxybenzene + O2 = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + 2 H(+)

Direction not assertedBalancedRhea 19673

9'-cis-neoxanthin + O2 = (3S,5R,6R)-3,5-dihydroxy-6,7-didehydro-5,6-dihydro-12'-apo-beta-caroten-12'-al + 2-cis,4-trans-xanthoxin

Direction not assertedBalancedRhea 19677

biotin + ATP + CoA = biotinyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 19681

(E)-feruloyl-CoA + tyramine = N-[(E)-feruloyl]tyramine + CoA + H(+)

Direction not assertedBalancedRhea 19685

L-rhamnulose 1-phosphate = (S)-lactaldehyde + dihydroxyacetone phosphate

Direction not assertedBalancedRhea 19689

5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + NAD(+) + H2O = 5-hydroxy-6-methylpyridine-3,4-dicarboxylate + NADH + 2 H(+)

Direction not assertedBalancedRhea 19693

11-cis-retinyl hexadecanoate + H2O = 11-cis-retinol + hexadecanoate + H(+)

Direction not assertedBalancedRhea 19697

a flavonol 3-O-glycoside + UDP-alpha-D-xylose = a flavonol 3-O-[beta-D-xylosyl-(1->2)-beta-D-glycoside] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 19701

hexadecanal + NAD(+) + CoA = hexadecanoyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 19705

a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA

Left to rightBalance undeterminableRhea 19709

(5Z,8Z,11Z,14Z)-eicosatetraenoate + ATP + CoA = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 19713

L-phenylalanine + H(+) = 2-phenylethylamine + CO2

Direction not assertedBalancedRhea 19717

octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 19721

UDP-alpha-D-galacturonate + H(+) = UDP-beta-L-arabinopyranose + CO2

Direction not assertedBalancedRhea 19725

acetoacetate + H(+) = acetone + CO2

Direction not assertedBalancedRhea 19729

3-deacetyl-3-(1-hydroxyethyl)bacteriochlorophyllide a + NAD(+) = bacteriochlorophyllide a + NADH + H(+)

Direction not assertedBalancedRhea 19733

4-(gamma-L-glutamylamino)butanoate + H2O = 4-aminobutanoate + L-glutamate

Direction not assertedBalancedRhea 19737

formyl-CoA + H2O = formate + CoA + H(+)

Direction not assertedBalancedRhea 19741

3,3',5-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

Right to leftBalancedRhea 19745

[(1->3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-alpha-D-glucosyl](n+1) + UDP + H(+)

Direction not assertedBalance undeterminableRhea 19749

diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)

Direction not assertedBalance undeterminableRhea 19753

(3R)-3-hydroxy-L-aspartate = oxaloacetate + NH4(+)

Direction not assertedBalancedRhea 19757

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