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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

15,101–15,150 of 31,435, by identifier

(R)-4-dehydropantoate + NAD(+) + H2O = (R)-3,3-dimethylmalate + NADH + 2 H(+)
Direction not assertedBalancedRhea 19349
glycocholate + H2O = cholate + glycine
Direction not assertedBalancedRhea 19353
L-proline betaine + NADPH + O2 + H(+) = N-methyl-L-proline + formaldehyde + NADP(+) + H2O
Direction not assertedBalancedRhea 19357
isopentenyl diphosphate + (2E)-geranyl diphosphate = (2E,6E)-farnesyl diphosphate + diphosphate
Direction not assertedBalancedRhea 19361
D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + H(+)
Direction not assertedBalancedRhea 19365
L-histidyl-[protein] + S-adenosyl-L-methionine = N(tele)-methyl-L-histidyl-[protein] + S-adenosyl-L-homocysteine + H(+)
Left to rightBalance undeterminableRhea 19369
L-saccharopine + NADP(+) + H2O = L-lysine + 2-oxoglutarate + NADPH + H(+)

Right to leftBalancedRhea 19373

reduced riboflavin + NADP(+) = riboflavin + NADPH + 2 H(+)

Right to leftBalancedRhea 19377

(S)-oxalosuccinate + H(+) = 2-oxoglutarate + CO2

Direction not assertedBalancedRhea 19381

vomilenine + UDP-alpha-D-glucose = raucaffricine + UDP + H(+)

Direction not assertedBalancedRhea 19385

(E)-ferulate + ATP + CoA = (E)-feruloyl-CoA + ADP + phosphate

Direction not assertedBalancedRhea 19389

L-lysine + pyruvate = (S)-2-amino-6-oxohexanoate + L-alanine

Direction not assertedBalancedRhea 19393

(R)-4'-phosphopantothenate + L-cysteine + CTP = N-[(R)-4-phosphopantothenoyl]-L-cysteine + CMP + diphosphate + H(+)

Left to rightBalancedRhea 19397

methanol + NAD(+) = formaldehyde + NADH + H(+)

Direction not assertedBalancedRhea 19401

citrate + acetyl-CoA = (3S)-citryl-CoA + acetate

Direction not assertedBalancedRhea 19405

cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + NADH + H(+)

Left to rightBalancedRhea 19409

tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)

Left to rightBalancedRhea 19413

a di-trans,poly-cis-dolichyl diphosphate + [phosphate](n) = [phosphate](n+1) + a di-trans,poly-cis-dolichyl phosphate

Direction not assertedBalance undeterminableRhea 19417

(R)-2-hydroxypropyl-coenzyme M = (R)-1,2-epoxypropane + coenzyme M

Direction not assertedBalancedRhea 19421

imidazole-4-acetate + NADH + O2 + H(+) = 5-hydroxyimidazole-4-acetate + NAD(+) + H2O

Direction not assertedBalancedRhea 19425

[beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H(+)

Left to rightBalance undeterminableRhea 19429

D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)

Left to rightBalancedRhea 19433

nicotinate + UDP-alpha-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP

Direction not assertedBalancedRhea 19437

benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate + 2 H(+)

Direction not assertedBalancedRhea 19441

2,3-dihydroxyindole + O2 = anthranilate + CO2 + H(+)

Direction not assertedBalancedRhea 19445

L-alanine + 2-oxoglutarate = pyruvate + L-glutamate

Direction not assertedBalancedRhea 19453

2-nitrophenol + 2 NADPH + O2 + 2 H(+) = catechol + nitrite + 2 NADP(+) + H2O

Direction not assertedBalancedRhea 19457

3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl)-L-seryl-[protein] + ATP = 3-O-(beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-2-O-phosphoxylosyl)-L-seryl-[protein] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 19461

2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)

Direction not assertedBalancedRhea 19465

2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)

Direction not assertedBalancedRhea 19469

4-hydroxybenzoate + NADH + O2 + H(+) = 3,4-dihydroxybenzoate + NAD(+) + H2O

Direction not assertedBalancedRhea 19473

4-hydroxybenzoate + NADPH + O2 + H(+) = 3,4-dihydroxybenzoate + NADP(+) + H2O

Direction not assertedBalancedRhea 19477

succinyl-CoA + acetyl-CoA = 3-oxoadipyl-CoA + CoA

Direction not assertedBalancedRhea 19481

sphing-4-enine + UDP-alpha-D-galactose = beta-D-galactosyl-(1<->1)-sphing-4-enine + UDP + H(+)

Direction not assertedBalancedRhea 19485

dibenzothiophene 5,5-dioxide + FMN-N(5)-peroxide = 2'-hydroxybiphenyl-2-sulfinate + FMN-N(5)-oxide + 2 H(+)

Direction not assertedBalancedRhea 19489

D-cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose

Direction not assertedBalancedRhea 19493

L-aspartate + H(+) = beta-alanine + CO2

Direction not assertedBalancedRhea 19497

4-guanidinobutanoate + H2O = urea + 4-aminobutanoate

Left to rightBalancedRhea 19501

indole-3-acetyl-1D-myo-inositol + UDP-beta-L-arabinopyranose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + UDP + H(+)

Direction not assertedBalancedRhea 19505

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = L-erythro-biopterin + 2 NADPH + 2 H(+)

Direction not assertedBalancedRhea 19509

carbamoyl phosphate + L-ornithine = L-citrulline + phosphate + H(+)

Right to leftBalancedRhea 19513

N,N-dimethylformamide + H2O = dimethylamine + formate

Direction not assertedBalancedRhea 19517

acetyl-CoA + phosphate = acetyl phosphate + CoA

Direction not assertedBalancedRhea 19521

(2E,6E)-farnesyl diphosphate = (1S,8aR)-delta-cadinene + diphosphate

Direction not assertedBalancedRhea 19525

isovitexin + UDP-alpha-D-glucose = isovitexin 2''-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 19529

N(2)-succinyl-L-arginine + 2 H2O + 2 H(+) = N(2)-succinyl-L-ornithine + 2 NH4(+) + CO2

Direction not assertedBalancedRhea 19533

D-mannitol 1-phosphate + H2O = D-mannitol + phosphate

Direction not assertedBalancedRhea 19537

L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 19541

sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol + H(+)

Left to rightBalancedRhea 19545

o-orsellinate depside + H2O = 2 orsellinate + H(+)

Direction not assertedBalancedRhea 19549

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