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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

15,001–15,050 of 31,435, by identifier

thiophene-2-carbonyl-CoA + AH2 + O2 = 5-hydroxythiophene-2-carbonyl-CoA + A + H2O + H(+)
Direction not assertedBalancedRhea 18929
(24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA = (24E)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-en-26-oyl-CoA + H2O
Right to leftBalancedRhea 18933
an N-acyl-L-homoserine lactone + H2O = L-homoserine lactone + a carboxylate
Direction not assertedBalance undeterminableRhea 18937
a (3R,4R)-3-[(1S)-1-hydroxyalkyl]-4-(hydroxymethyl)oxolan-2-one + NADP(+) = a (3R,4R)-3-alkanoyl-4-(hydroxymethyl)oxolan-2-one + NADPH + H(+)
Direction not assertedBalance undeterminableRhea 18941
L-prolyl-[collagen] + 2-oxoglutarate + O2 = trans-4-hydroxy-L-prolyl-[collagen] + succinate + CO2
Left to rightBalance undeterminableRhea 18945
taxa-4(20),11-dien-5alpha-ol + reduced [NADPH--hemoprotein reductase] + O2 = taxa-4(20),11-dien-5alpha,13alpha-diol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not asserted

?

Balance undeterminable

Rhea 18949

L-erythro-7,8-dihydrobiopterin + NADP(+) = L-sepiapterin + NADPH + H(+)

Right to leftBalancedRhea 18953

(4R)-limonene + reduced [NADPH--hemoprotein reductase] + O2 = (1R,5S)-carveol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 18957

D-allose + L-lysyl-[protein] = N(6)-(D-psicosyl)-L-lysyl-[protein] + H2O

Direction not assertedBalance undeterminableRhea 18961

hydroxymethylbilane = uroporphyrinogen III + H2O

Direction not assertedBalancedRhea 18965

a long-chain fatty acid + hnu + H(+) = a long-chain alkane + CO2

Direction not assertedBalance undeterminableRhea 18969

deacetoxyvindoline + 2-oxoglutarate + O2 = 4-O-deacetylvindoline + succinate + CO2

Direction not assertedBalancedRhea 18973

a quinone + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + a quinol

Left to rightBalance undeterminableRhea 18977

(R)-pantolactone + NADP(+) = 2-dehydropantolactone + NADPH + H(+)

Direction not assertedBalancedRhea 18981

chorismate = isochorismate

Direction not assertedBalancedRhea 18985

L-valine + H(+) = 2-methylpropan-1-amine + CO2

Direction not assertedBalancedRhea 18989

(9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate

Direction not assertedBalancedRhea 18993

phosphocholine + CTP + H(+) = CDP-choline + diphosphate

Left to rightBalancedRhea 18997

a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

Direction not assertedBalance undeterminableRhea 19009

dTTP + H2O = dTDP + phosphate + H(+)

Direction not assertedBalancedRhea 19013

(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)

Direction not assertedBalancedRhea 19017

an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + UDP + H(+)

Left to rightBalance undeterminableRhea 19021

L-aspartate + O2 + H2O = oxaloacetate + H2O2 + NH4(+)

Direction not assertedBalancedRhea 19025

urea-1-carboxylate + H2O + 3 H(+) = 2 NH4(+) + 2 CO2

Direction not assertedBalancedRhea 19029

an N-acyl-D-glucosamine = an N-acyl-D-mannosamine

ReversibleBalance undeterminableRhea 19033

an epoxide + H2O = an ethanediol

Left to rightBalance undeterminableRhea 19037

(25R)-cholest-5-ene-3beta,26-diol + reduced [NADPH--hemoprotein reductase] + O2 = (25R)-cholest-5-en-3beta,7alpha,26-triol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 19041

pyruvate + acetyl-CoA + H2O = (3R)-citramalate + CoA + H(+)

Direction not assertedBalancedRhea 19045

(5R)-5-hydroxy-L-lysine + GTP = (5R)-5-phosphooxy-L-lysine + GDP + H(+)

Direction not assertedBalancedRhea 19049

5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H2O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H(+)

Direction not assertedBalancedRhea 19053

a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2O

Left to rightBalance undeterminableRhea 19057

nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)

Direction not assertedBalancedRhea 19061

(R)-S-lactoylglutathione = methylglyoxal + glutathione

Right to leftBalancedRhea 19069

L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 19073

N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] + H2O = 3-deoxyglucosone + L-lysyl-[protein] + phosphate

Direction not assertedBalance undeterminableRhea 19077

1-haloalkane + H2O = a halide anion + a primary alcohol + H(+)

Direction not assertedBalance undeterminableRhea 19081

dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate

Direction not assertedBalancedRhea 19085

uroporphyrinogen III + S-adenosyl-L-methionine = precorrin-1 + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 19089

siroheme + 2 H(+) = 12,18-didecarboxysiroheme + 2 CO2

Direction not assertedBalancedRhea 19093

2-butyne-1,4-diol + NAD(+) = 4-hydroxy-2-butynal + NADH + H(+)

Direction not assertedBalancedRhea 19101

4-aminobutanal + NAD(+) + H2O = 4-aminobutanoate + NADH + 2 H(+)

Left to rightBalancedRhea 19105

1,2,3,6-tetrakis-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose + D-glucose + H(+)

Direction not assertedBalancedRhea 19109

(8Z,11Z,14Z)-heptadecatrienal + A + H2O = (8Z,11Z,14Z)-heptadecatrienoate + AH2 + H(+)

Direction not assertedBalancedRhea 19113

dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O

Left to rightBalancedRhea 19117

an S-substituted glutathione(in) + ATP + H2O = an S-substituted glutathione(out) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 19121

glyoxylate + L-serine = 3-hydroxypyruvate + glycine

Direction not assertedBalancedRhea 19125

thymidine + ATP = dTMP + ADP + H(+)

Left to rightBalancedRhea 19129

3,3',5-triiodo-L-thyronine + 2-oxoglutarate = 3,5,3'-triiodothyropyruvate + L-glutamate

Direction not assertedBalancedRhea 19133

17beta-estradiol + AH2 + O2 = 6beta-hydroxyestradiol-17beta + A + H2O

Direction not assertedBalancedRhea 19137

all-trans-retinol = 11-cis-retinol

ReversibleBalancedRhea 19141

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