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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

14,951–15,000 of 31,435, by identifier

taurine + A + H2O = sulfoacetaldehyde + AH2 + NH4(+)
Direction not assertedBalancedRhea 18709
3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine
Direction not assertedBalancedRhea 18717
ent-8alpha-hydroxylabd-13-en-15-yl diphosphate = ent-13-epi-manoyl oxide + diphosphate
Direction not assertedBalancedRhea 18721
3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = vanillin + acetyl-CoA
Direction not assertedBalancedRhea 18725
hydrogenselenide + ATP + H2O = selenophosphate + AMP + phosphate + 2 H(+)
Left to rightBalancedRhea 18737
10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA
Direction not assertedBalancedRhea 18741
2 juglone + O2 = 2 3,5-dihydroxy-1,4-naphthoquinone + 2 H(+)

Direction not assertedBalancedRhea 18745

[protein]-dithiol + NAD(+) = [protein]-disulfide + NADH + H(+)

Direction not assertedBalance undeterminableRhea 18749

[protein]-dithiol + NADP(+) = [protein]-disulfide + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 18753

7-deoxycylindrospermopsin + 2-oxoglutarate + O2 = cylindrospermopsin + succinate + CO2

Direction not assertedBalancedRhea 18757

a 1,2-diacyl-sn-glycerol + H2O = a monoacylglycerol + a fatty acid + H(+)

Direction not assertedBalance undeterminableRhea 18761

an N-acylsphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sphingomyelin + a 1,2-diacyl-sn-glycerol

ReversibleBalance undeterminableRhea 18765

5-methylsulfanyl-2,3-dioxopentyl phosphate = 2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate

Direction not assertedBalancedRhea 18769

methyl-Co(III)-[methylamine-specific corrinoid protein] + coenzyme M = Co(I)-[methylamine-specific corrinoid protein] + methyl-coenzyme M + H(+)

Direction not assertedBalance undeterminableRhea 18773

an alkylmercury + H(+) = an alkane + Hg(2+)

Direction not assertedBalance undeterminableRhea 18777

malonyl-CoA + H(+) = acetyl-CoA + CO2

Left to rightBalancedRhea 18781

gibberellin A12 aldehyde + A + H2O = gibberellin A12 + AH2 + H(+)

Direction not assertedBalancedRhea 18785

D-glucosamine 6-phosphate = D-galactosamine 6-phosphate

Direction not assertedBalancedRhea 18789

alpha-D-ribose 1-phosphate = D-ribose 5-phosphate

Direction not assertedBalancedRhea 18793

a 3'-hydroxy,5'-unsubstituted flavanone + reduced [NADPH--hemoprotein reductase] + O2 = a 3',5'-dihydroxyflavanone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 18797

(cis-prenyl)(n)-diphosphate + isopentenyl diphosphate = (cis-prenyl)(n+1)-diphosphate + diphosphate

Direction not assertedBalance undeterminableRhea 18801

[DsbA protein]-disulfide + [protein]-dithiol = [DsbA protein]-dithiol + [protein]-disulfide

Direction not assertedBalance undeterminableRhea 18805

oxomalonate + L-alanine = aminomalonate + pyruvate

Direction not assertedBalancedRhea 18809

(2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate = (3E,5R)-5-carboxy-2-oxohept-3-enedioate

Direction not assertedBalancedRhea 18813

malonate + acetyl-CoA = acetate + malonyl-CoA

Direction not assertedBalancedRhea 18817

choline + acetyl-CoA = acetylcholine + CoA

Direction not assertedBalancedRhea 18821

[(1->6)-alpha-D-glucosyl](n) + sucrose = [(1->6)-alpha-D-glucosyl](n+1) + D-fructose

Direction not assertedBalance undeterminableRhea 18825

4-phospho-D-erythronate + NAD(+) = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + NADH + H(+)

Direction not assertedBalancedRhea 18829

4-formylbenzenesulfonate + NAD(+) + H2O = 4-sulfobenzoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 18833

10-deacetyltaxuyunnanin C + acetyl-CoA = taxuyunnanin C + CoA

Direction not assertedBalancedRhea 18837

(R)-glycerate + NADP(+) = 2-hydroxy-3-oxopropanoate + NADPH + H(+)

Direction not assertedBalancedRhea 18841

(R)-glycerate + NAD(+) = 2-hydroxy-3-oxopropanoate + NADH + H(+)

Direction not assertedBalancedRhea 18845

a 2'-unsubstituted isoflavone + reduced [NADPH--hemoprotein reductase] + O2 = a 2'-hydroxyisoflavone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 18849

tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + NADH + H(+)

Direction not assertedBalancedRhea 18853

lithocholate + reduced [NADPH--hemoprotein reductase] + O2 = 6beta-hydroxylithocholate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 18857

a 5-hydroxyfurocoumarin + S-adenosyl-L-methionine = a 5-methoxyfurocoumarin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 18861

N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 2-methylpropanoyl-CoA = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CoA

Right to leftBalance undeterminableRhea 18865

L-xylulose + ATP = L-xylulose 5-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 18869

3-chloro-D-alanine + H2O = chloride + pyruvate + NH4(+) + H(+)

Direction not assertedBalancedRhea 18873

myo-inositol + S-adenosyl-L-methionine = 1D-3-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 18877

histamine + L-glutamate + ATP = N(alpha)-gamma-L-glutamylhistamine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 18881

GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + NADPH + H(+)

Direction not assertedBalancedRhea 18885

D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-trehalose 6-phosphate + UDP + H(+)

Direction not assertedBalancedRhea 18889

a flavonol 3-O-beta-D-glucoside + UDP-alpha-D-glucose = a flavonol 3-O-beta-D-glucosyl-(1->2)-beta-D-glucoside + UDP + H(+)

Direction not assertedBalance undeterminableRhea 18893

3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2

Right to leftBalancedRhea 18897

N-benzyloxycarbonyl-L-leucine + H2O + H(+) = benzyl alcohol + L-leucine + CO2

Direction not assertedBalancedRhea 18901

phosphonoacetaldehyde + H2O = acetaldehyde + phosphate + H(+)

Direction not assertedBalancedRhea 18905

2,4,6-trichlorophenol + S-adenosyl-L-methionine = 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 18909

a neolactoside nLc4Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer(d18:1(4E)) + CMP + H(+)

Left to rightBalance undeterminableRhea 18913

L-gulono-1,4-lactone + NADP(+) = D-glucurono-3,6-lactone + NADPH + H(+)

Direction not assertedBalancedRhea 18925

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