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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

14,801–14,850 of 31,435, by identifier

methanophenazine + coenzyme B + coenzyme M = dihydromethanophenazine + coenzyme M-coenzyme B heterodisulfide
Direction not assertedBalancedRhea 18085
L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+)
Left to rightBalance undeterminableRhea 18089
5,6-dihydrouracil + NADP(+) = uracil + NADPH + H(+)
Right to leftBalancedRhea 18093
pteridine-2,4,6,7-tetrol = xanthine-8-carboxylate + H(+)
Direction not assertedBalancedRhea 18097
cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + NADH + H(+)
Direction not assertedBalancedRhea 18101
Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)
Left to rightBalancedTransportRhea 18105
sn-3-O-(geranylgeranyl)glycerol 1-phosphate + (2E,6E,10E)-geranylgeranyl diphosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate

Direction not assertedBalancedRhea 18109

a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP

Left to rightBalance undeterminableRhea 18113

L-tyrosine + O2 = L-dopaquinone + H2O

Left to rightBalancedRhea 18117

an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)

Left to rightBalance undeterminableRhea 18121

a D-alpha-amino acid + A + H2O = a 2-oxocarboxylate + AH2 + NH4(+)

Direction not assertedBalance undeterminableRhea 18125

2-oxoaldehyde + NADP(+) + H2O = a 2-oxocarboxylate + NADPH + 2 H(+)

Direction not assertedBalance undeterminableRhea 18129

sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate

Left to rightBalancedRhea 18133

3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) = 5alpha-pregnane-3,20-dione + NADPH + H(+)

Direction not assertedBalancedRhea 18137

trans-cyclohexane-1,2-diol + NAD(+) = 2-hydroxycyclohexan-1-one + NADH + H(+)

Direction not assertedBalancedRhea 18141

beta-D-fructose + ATP = beta-D-fructose 1-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 18145

N-acetyl-D-galactosamine 6-phosphate + H2O = D-galactosamine 6-phosphate + acetate

Direction not assertedBalancedRhea 18149

2 GTP + H(+) = P(1),P(4)-bis(5'-guanosyl) tetraphosphate + diphosphate

Direction not assertedBalancedRhea 18153

pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)

Right to leftBalancedRhea 18157

tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA

Right to leftBalancedRhea 18161

biphenyl + NADH + O2 + H(+) = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)

Direction not assertedBalancedRhea 18165

4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

Direction not assertedBalancedRhea 18169

(R)-octopamine = (4-hydroxyphenyl)acetaldehyde + NH4(+)

Direction not assertedBalancedRhea 18173

a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + NADH + H(+)

Direction not assertedBalance undeterminableRhea 18177

glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

Direction not assertedBalancedRhea 18181

adenosine + O2 = 5'-dehydroadenosine + H2O2

Direction not assertedBalancedRhea 18185

[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)

Direction not assertedBalance undeterminableRhea 18189

N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + H2O = (S)-4,5-dihydroxy-2-oxopentanal + L-lysyl-[protein] + phosphate

Direction not assertedBalance undeterminableRhea 18193

N-cyclohexylformamide = cyclohexyl isocyanide + H2O

Direction not assertedBalancedRhea 18197

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-dopa

Left to rightBalancedRhea 18201

(2E)-geranyl diphosphate = (2S,4R)-bornyl diphosphate

Direction not assertedBalancedRhea 18209

alpha-D-glucose 1-phosphate + CTP + H(+) = CDP-D-glucose + diphosphate

Direction not assertedBalancedRhea 18213

an alkane-alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate

Direction not assertedBalance undeterminableRhea 18217

a 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphate + H2O = a 1-O-alkyl-2-acetyl-sn-glycerol + phosphate

Direction not assertedBalance undeterminableRhea 18221

[N-(6-aminohexanoyl)](n) + H2O = [N-(6-aminohexanoyl)](n-1) + 6-aminohexanoate

Direction not assertedBalance undeterminableRhea 18225

glycolate + NAD(+) = glyoxylate + NADH + H(+)

Direction not assertedBalancedRhea 18229

2,5-dihydroxybenzoate + O2 = 3-maleylpyruvate + H(+)

Direction not assertedBalancedRhea 18237

D-lysine = (2R,5S)-2,5-diaminohexanoate

Direction not assertedBalancedRhea 18241

3'-dephospho-CoA + ATP = ADP + CoA + H(+)

Left to rightBalancedRhea 18245

(S)-malate + NADP(+) = pyruvate + CO2 + NADPH

ReversibleBalancedRhea 18253

coproporphyrinogen III + O2 + 2 H(+) = protoporphyrinogen IX + 2 CO2 + 2 H2O

Left to rightBalancedRhea 18257

precorrin-5 + S-adenosyl-L-methionine + H2O = precorrin-6A + acetate + S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalancedRhea 18261

6-hydroxycyclohex-1-ene-1-carbonyl-CoA + NAD(+) = 6-oxocyclohex-1-ene-1-carbonyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 18265

ethyl (S)-3-hydroxyhexanoate + NADP(+) = ethyl 3-oxohexanoate + NADPH + H(+)

Direction not assertedBalancedRhea 18269

putrescine + O2 + H2O = 4-aminobutanal + H2O2 + NH4(+)

Left to rightBalancedRhea 18273

a thiol + S-adenosyl-L-methionine = a methyl thioether + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 18277

succinate + NAD(+) = fumarate + NADH + H(+)

Direction not assertedBalancedRhea 18281

an N-acyl-D-aspartate + H2O = D-aspartate + a carboxylate

Direction not assertedBalance undeterminableRhea 18285

(S,S)-tartrate = oxaloacetate + H2O

Direction not assertedBalancedRhea 18289

oxalate + ATP + CoA = oxalyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 18293

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