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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

14,751–14,800 of 31,435, by identifier

an R-cob(III)alamin(out) + ATP + H2O = an R-cob(III)alamin(in) + ADP + phosphate + H(+)
Left to rightBalance undeterminableTransportRhea 17873
a catechol + S-adenosyl-L-methionine = a guaiacol + S-adenosyl-L-homocysteine + H(+)
Left to rightBalance undeterminableRhea 17877
N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
Direction not assertedBalancedRhea 17881
acetaldehyde = acetylene + H2O
Direction not assertedBalancedRhea 17885
phosphoethanolamine + H2O = acetaldehyde + NH4(+) + phosphate
Direction not assertedBalancedRhea 17889
ethylbenzene + A + H2O = (S)-1-phenylethanol + AH2
Direction not assertedBalancedRhea 17897
xanthotoxol + S-adenosyl-L-methionine = xanthotoxin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17901

(R)-glycerate + NAD(+) = 3-hydroxypyruvate + NADH + H(+)

Direction not assertedBalancedRhea 17905

(S)-lactate = acetaldehyde + formate

Direction not assertedBalancedRhea 17909

nitrite + NAD(+) + H2O = nitrate + NADH + H(+)

Direction not assertedBalancedRhea 17913

[Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly + glycine

Direction not assertedBalance undeterminableRhea 17917

D-arabinitol + NAD(+) = D-xylulose + NADH + H(+)

Direction not assertedBalancedRhea 17921

alpha-L-arabinopyanose + NAD(+) = L-arabinono-1,4-lactone + NADH + H(+)

Direction not assertedBalancedRhea 17925

an N-acylsphing-4-enine + ATP = an N-acylsphing-4-enine 1-phosphate + ADP + H(+)

Left to rightBalance undeterminableRhea 17929

a 7-hydroxyisoflavone + S-adenosyl-L-methionine = a 7-methoxyisoflavone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 17933

dihydroxyacetone phosphate = methylglyoxal + phosphate

Direction not assertedBalancedRhea 17937

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O

Direction not assertedBalancedRhea 17941

(4S)-limonene + reduced [NADPH--hemoprotein reductase] + O2 = (1S,5R)-carveol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 17945

3-hydroxy-1H-quinolin-4-one + O2 = N-formylanthranilate + CO + H(+)

Direction not assertedBalancedRhea 17949

3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde

Direction not assertedBalancedRhea 17953

3-oxopropanoate = propynoate + H2O

Direction not assertedBalancedRhea 17957

(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O

Left to rightBalancedRhea 17961

(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) = (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O

Direction not assertedBalancedRhea 17965

UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine + ATP = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 17969

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate

Right to leftBalancedRhea 17973

a long-chain primary fatty alcohol + 2 NAD(+) + H2O = a long-chain fatty acid + 2 NADH + 3 H(+)

Direction not assertedBalance undeterminableRhea 17977

4-(trimethylamino)butanal + NAD(+) + H2O = 4-(trimethylamino)butanoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 17985

L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)

Left to rightBalance undeterminableRhea 17989

gamma-L-glutamyl-L-cysteine + beta-alanine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 17993

Co-precorrin-2 + S-adenosyl-L-methionine = Co-precorrin-3 + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17997

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)

Direction not assertedBalance undeterminableRhea 18001

D-threitol + NADP(+) = D-erythrulose + NADPH + H(+)

Direction not assertedBalancedRhea 18005

glutaryl-CoA + L-lysyl-[protein] = N(6)-glutaryl-L-lysyl-[protein] + CoA + H(+)

Left to rightBalance undeterminableRhea 18009

N(5)-ethyl-L-glutamine + H2O = ethylamine + L-glutamate

Direction not assertedBalancedRhea 18013

indole-3-pyruvate + H(+) = indole-3-acetaldehyde + CO2

Direction not assertedBalancedRhea 18017

a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+)

Left to rightBalance undeterminableRhea 18021

hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)

Direction not assertedBalancedRhea 18029

benzoate + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxybenzoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 18033

agmatine + H2O = N-carbamoylputrescine + NH4(+)

Direction not assertedBalancedRhea 18037

6 oxidized [2Fe-2S]-[ferredoxin] + NH4(+) + 2 H2O = nitrite + 6 reduced [2Fe-2S]-[ferredoxin] + 8 H(+)

Direction not assertedBalance undeterminableRhea 18041

6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O = alpha-D-mannose derivative + alpha-D-glucose 1-phosphate + H(+)

Direction not assertedBalance undeterminableRhea 18045

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate

Direction not assertedBalancedRhea 18049

paraoxon + H2O = diethylphosphate + 4-nitrophenol + 2 H(+)

Direction not assertedBalancedRhea 18053

Watasenia luciferin + O2 = oxidized Watasenia luciferin + hnu + CO2

Direction not assertedBalance undeterminableRhea 18057

N-formylmethanofuran + 5,6,7,8-tetrahydromethanopterin + H(+) = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran

Direction not assertedBalancedRhea 18061

phosphonate(out) + ATP + H2O = phosphonate(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 18065

L-arginine = D-arginine

Direction not assertedBalancedRhea 18069

(S)-dihydroorotate + A = orotate + AH2

Direction not assertedBalancedRhea 18073

L-arginyl-[dinitrogen reductase] + NAD(+) = N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide + H(+)

Direction not assertedBalance undeterminableRhea 18077

(2E,6E)-farnesyl diphosphate = pentalenene + diphosphate

Direction not assertedBalancedRhea 18081

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