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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

14,701–14,750 of 31,435, by identifier

succinate + ATP + CoA = succinyl-CoA + ADP + phosphate
Direction not assertedBalancedRhea 17661
octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)
Left to rightBalance undeterminableRhea 17665
3-(2-hydroxyphenyl)propanoate + NADH + O2 + H(+) = 3-(2,3-dihydroxyphenyl)propanoate + NAD(+) + H2O
Direction not assertedBalancedRhea 17669
quercetin + S-adenosyl-L-methionine = 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 17673
2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H2O + H(+) = 2-(hydroxymethyl)-4-oxobutanoate + acetate + NH4(+) + CO2
Direction not assertedBalancedRhea 17677
3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)
Direction not assertedBalancedRhea 17681

uracil 5-carboxylate + H(+) = uracil + CO2

Direction not assertedBalancedRhea 17685

glycochenodeoxycholate + 3'-phosphoadenylyl sulfate = glycochenodeoxycholate 7-sulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 17689

pyridine + thiamine = heteropyrithiamine + 5-(2-hydroxyethyl)-4-methylthiazole

Direction not assertedBalancedRhea 17697

geranoyl-CoA + hydrogencarbonate + ATP = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 17701

all-trans-nonaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-nonaprenyl)benzoate + diphosphate

Left to rightBalancedRhea 17709

(R)-reticuline + reduced [NADPH--hemoprotein reductase] + O2 = salutaridine + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 17713

1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)

Direction not assertedBalancedRhea 17717

a long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 17721

(2S,3S)-2-methylcitrate = 2-methyl-cis-aconitate + H2O

Direction not assertedBalancedRhea 17725

an acyl-CoA + cholesterol = a cholesterol ester + CoA

Left to rightBalance undeterminableRhea 17729

acetylenedicarboxylate + H2O + H(+) = pyruvate + CO2

Direction not assertedBalancedRhea 17733

shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)

Direction not assertedBalancedRhea 17737

shikimate + NAD(+) = 3-dehydroshikimate + NADH + H(+)

Direction not assertedBalancedRhea 17741

N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + UDP + H(+)

Left to rightBalancedRhea 17745

quinoline + A + H2O = quinolin-2(1H)-one + AH2

Direction not assertedBalancedRhea 17749

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine

Direction not assertedBalancedRhea 17753

L-methionine + H(+) = 3-(methylsulfanyl)propanamine + CO2

Direction not assertedBalancedRhea 17757

an aromatic primary alcohol + NADP(+) = an aromatic aldehyde + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 17761

(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)

ReversibleBalancedRhea 17765

choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 17769

tRNA(Cys) + L-cysteine + ATP = L-cysteinyl-tRNA(Cys) + AMP + diphosphate

ReversibleBalancedRhea 17773

a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)

Left to rightBalance undeterminableRhea 17777

N(alpha)-formyl-L-methionine + H2O = formate + L-methionine

Left to rightBalancedRhea 17781

L-glutamate + H(+) = 4-aminobutanoate + CO2

Left to rightBalancedRhea 17785

(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine = (S)-reticuline + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17789

L-alanyl-tRNA(Thr) + H2O = tRNA(Thr) + L-alanine + H(+)

Direction not assertedBalancedRhea 17793

[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)

Direction not assertedBalance undeterminableRhea 17797

L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H(+)

Direction not assertedBalancedRhea 17801

S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Direction not assertedBalancedRhea 17805

Mg-protoporphyrin IX + S-adenosyl-L-methionine = Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 17809

D-altronate + NAD(+) = keto-D-tagaturonate + NADH + H(+)

Direction not assertedBalancedRhea 17813

UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine + (3R)-hydroxytetradecanoyl-[ACP] = UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine + holo-[ACP] + H(+)

Direction not assertedBalance undeterminableRhea 17817

hydrogen cyanide + L-cysteine = 3-cyano-L-alanine + hydrogen sulfide + H(+)

Direction not assertedBalancedRhea 17821

D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)

Left to rightBalancedRhea 17825

3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17833

2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate

Direction not assertedBalancedRhea 17837

trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine = O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 17841

5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH + H(+)

Direction not assertedBalancedRhea 17845

(3R)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O

Direction not assertedBalancedRhea 17849

keto-L-sorbose + O2 = 5-dehydro-D-fructose + H2O2

Direction not assertedBalancedRhea 17853

taurochenodeoxycholate + reduced [NADPH--hemoprotein reductase] + O2 = taurohyocholate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 17857

21-hydroxyprogesterone = 20-hydroxy-3-oxopregn-4-en-21-al

Direction not assertedBalancedRhea 17861

5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + NADPH + H(+)

Right to leftBalancedRhea 17865

5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + NADH + H(+)

Right to leftBalancedRhea 17869

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