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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

14,651–14,700 of 31,435, by identifier

flaviolin + (2E)-geranyl diphosphate = 3-linalylflaviolin + diphosphate
Direction not assertedBalancedRhea 17449
5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)
Left to rightBalancedRhea 17453
L-cysteinyl-[cysteine desulfurase] + L-cysteine = S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + L-alanine
Direction not assertedBalance undeterminableRhea 17457
D-sedoheptulose 1,7-bisphosphate + H2O = D-sedoheptulose 7-phosphate + phosphate
Direction not assertedBalancedRhea 17461
quercitrin + H2O = L-rhamnopyranose + quercetin
Direction not assertedBalancedRhea 17465
all-trans-retinol--[retinol-binding protein] + a 1,2-diacyl-sn-glycero-3-phosphocholine = apo--[retinol-binding protein] + an all-trans-retinyl ester + a 2-acyl-sn-glycero-3-phosphocholine
Left to rightBalance undeterminableRhea

17469

GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)

Direction not assertedBalancedRhea 17473

precorrin-6B + 2 S-adenosyl-L-methionine = precorrin-8X + 2 S-adenosyl-L-homocysteine + CO2 + 3 H(+)

Direction not assertedBalancedRhea 17477

2 cob(I)alamin + NAD(+) + H(+) = 2 cob(II)alamin + NADH

Direction not assertedBalancedRhea 17481

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

Left to rightBalancedRhea 17485

phthalate + NADH + O2 + H(+) = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)

Direction not assertedBalancedRhea 17489

glycerol + A = dihydroxyacetone + AH2

Direction not assertedBalancedRhea 17493

formononetin + UDP-alpha-D-glucose = ononin + UDP

Direction not assertedBalancedRhea 17497

polyneuridine aldehyde + H2O = 16-epivellosimine + methanol + CO2

Direction not assertedBalancedRhea 17501

an N-(long-chain fatty acyl)ethanolamine + H2O = a long-chain fatty acid + ethanolamine

Left to rightBalance undeterminableRhea 17505

thiamine + H2O = 5-(2-hydroxyethyl)-4-methylthiazole + 4-amino-5-hydroxymethyl-2-methylpyrimidine + H(+)

Direction not assertedBalancedRhea 17509

an N-(long-chain-fatty-acyl)-L-glutamate + H2O = a long-chain fatty acid + L-glutamate

Direction not assertedBalance undeterminableRhea 17517

L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 17521

biuret + H2O = urea-1-carboxylate + NH4(+)

Direction not assertedBalancedRhea 17525

an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate

Direction not assertedBalance undeterminableRhea 17533

(R)-carnitinamide + H2O = (R)-carnitine + NH4(+)

Direction not assertedBalancedRhea 17537

an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2

Direction not assertedBalance undeterminableRhea 17541

S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate

Direction not assertedBalance undeterminableRhea 17545

a 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = a 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 17549

guanidinoethyl methyl phosphate + ATP = N'-phosphoguanidinoethyl methylphosphate + ADP + H(+)

Direction not assertedBalancedRhea 17553

anthranilate + malonyl-CoA = N-malonylanthranilate + CoA

Direction not assertedBalancedRhea 17557

acetylcholine + H2O = choline + acetate + H(+)

Left to rightBalancedRhea 17561

myo-inositol + S-adenosyl-L-methionine = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17565

(R)-reticuline + NADP(+) = 1,2-dehydroreticuline + NADPH + H(+)

Direction not assertedBalancedRhea 17569

demethylmacrocin + S-adenosyl-L-methionine = macrocin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17573

ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose

Direction not assertedBalancedRhea 17577

an N-carbamoyl-L-alpha-amino acid + H2O + 2 H(+) = an L-alpha-amino acid + NH4(+) + CO2

Direction not assertedBalance undeterminableRhea 17581

2,2'-iminodipropanoate + NAD(+) + H2O = L-alanine + pyruvate + NADH + H(+)

Direction not assertedBalancedRhea 17589

3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine

Direction not assertedBalancedRhea 17593

D-mannitol + 2 Fe(III)-[cytochrome c] = D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+)

Direction not assertedBalance undeterminableRhea 17597

D-ribulose + ATP = D-ribulose 5-phosphate + ADP + H(+)

Left to rightBalancedRhea 17601

C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine + ATP = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 17605

L-seryl-[sulfatase] + S-adenosyl-L-methionine = 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + L-methionine + H(+)

Direction not assertedBalance undeterminableRhea 17609

scyllo-inositol + NAD(+) = scyllo-inosose + NADH + H(+)

Direction not assertedBalancedRhea 17613

leukotriene C4 = leukotriene A4 + glutathione

ReversibleBalancedRhea 17617

citramalate + acetyl-CoA = (3S)-citramalyl-CoA + acetate

Direction not assertedBalancedRhea 17621

D-lysopine + NADP(+) + H2O = L-lysine + pyruvate + NADPH + H(+)

Direction not assertedBalancedRhea 17625

alpha,alpha-trehalose(in) = alpha,alpha-trehalose(out)

Right to leftBalancedTransportRhea 17629

a beta-D-glucuronoside + H2O = D-glucuronate + an alcohol

Left to rightBalance undeterminableRhea 17633

squalene = hop-22(29)-ene

Direction not assertedBalancedRhea 17637

L-arginine + H(+) = agmatine + CO2

Direction not assertedBalancedRhea 17641

N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] + H2O = N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate

Direction not assertedBalance undeterminableRhea 17645

acetyl-[ACP] + malonate = malonyl-[ACP] + acetate

Direction not assertedBalance undeterminableRhea 17649

isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate

Direction not assertedBalancedRhea 17653

dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

Left to rightBalance undeterminableRhea 17657

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