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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

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Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

14,601–14,650 of 31,435, by identifier

L-fucose = L-fuculose
Direction not assertedBalancedRhea 17233
FMN + ATP + H(+) = FAD + diphosphate
Left to rightBalancedRhea 17237
an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol + H(+)
Direction not assertedBalance undeterminableRhea 17241
3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2
Direction not assertedBalancedRhea 17245
2 Fe(2+) + H2O2 + 2 H2O = 2 iron(III) oxide-hydroxide + 6 H(+)
Direction not assertedBalancedRhea 17249
vinorine + reduced [NADPH--hemoprotein reductase] + O2 = vomilenine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminableRhea 17257
an aryl sulfate + H2O = a phenol + sulfate + H(+)

Direction not assertedBalance undeterminableRhea 17261

trans-aconitate = cis-aconitate

Direction not assertedBalancedRhea 17265

macrocin + S-adenosyl-L-methionine = tylosin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17269

(4-hydroxyphenyl)acetaldehyde + NAD(+) + H2O = 4-hydroxyphenylacetate + NADH + 2 H(+)

Direction not assertedBalancedRhea 17273

6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O

Direction not assertedBalancedRhea 17277

(2S)-4-acetamido-2-aminobutanoate = L-ectoine + H2O

Direction not assertedBalancedRhea 17281

a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP + H(+)

Direction not assertedBalance undeterminableRhea 17285

beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate

Left to rightBalancedRhea 17289

precorrin-3A + NADH + O2 + 2 H(+) = precorrin-3B + NAD(+) + H2O

Direction not assertedBalancedRhea 17293

2 oxidized [2Fe-2S]-[ferredoxin] + 2-oxoglutarate + CoA = succinyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + H(+)

Direction not assertedBalance undeterminableRhea 17297

L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+)

Left to rightBalance undeterminableRhea 17301

N(omega),N(omega)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

Left to rightBalancedRhea 17305

a phenyl acetate + H2O = a phenol + acetate + H(+)

Direction not assertedBalance undeterminableRhea 17309

tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 17313

phytyl diphosphate + chlorophyllide a + H(+) = chlorophyll a + diphosphate

Direction not assertedBalancedRhea 17317

L-tryptophan + S-adenosyl-L-methionine = 2-methyl-L-tryptophan + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17321

(S)-2,3,4,5-tetrahydrodipicolinate + succinyl-CoA + H2O = (S)-2-succinylamino-6-oxoheptanedioate + CoA

Direction not assertedBalancedRhea 17325

(1R,2S,4R)-borneol + NAD(+) = (1R,4R)-camphor + NADH + H(+)

Direction not assertedBalancedRhea 17329

zeatin + O-acetyl-L-serine = L-lupinate + acetate + H(+)

Direction not assertedBalancedRhea 17333

catechol + O2 = (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)

Direction not assertedBalancedRhea 17337

1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 17341

(S)-methylmalonyl-CoA + H2O = methylmalonate + CoA + H(+)

Direction not assertedBalancedRhea 17345

3-[(Z)-2-isocyanoethenyl]-1H-indole + (2E)-geranyl diphosphate = 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate

Direction not assertedBalancedRhea 17349

2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2

Left to rightBalance undeterminableRhea 17357

3-oxo-3-ureidopropanoate + H2O = malonate + urea + H(+)

Direction not assertedBalancedRhea 17361

Mn(2+)(out) + ATP + H2O = Mn(2+)(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 17365

glycyrrhizin + H2O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate

Direction not assertedBalancedRhea 17369

all-trans-antheraxanthin = all-trans-capsanthin

Direction not assertedBalancedRhea 17373

a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)

Left to rightBalance undeterminableRhea 17377

(9Z,12Z)-octadecadienoate = (9Z,11E)-octadecadienoate

Direction not assertedBalancedRhea 17381

D-arabinitol + NAD(+) = D-ribulose + NADH + H(+)

Direction not assertedBalancedRhea 17389

3-maleylpyruvate = 3-fumarylpyruvate

Direction not assertedBalancedRhea 17393

a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)

Right to leftBalance undeterminableRhea 17397

2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate + H2O

Direction not assertedBalancedRhea 17401

N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17405

(S)-coclaurine + S-adenosyl-L-methionine = (S)-N-methylcoclaurine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17409

a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)

Direction not assertedBalance undeterminableRhea 17413

N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + H(+)

Left to rightBalancedRhea 17417

pyruvate + NADP(+) + CoA = acetyl-CoA + CO2 + NADPH

Direction not assertedBalancedRhea 17425

trans-4-hydroxycyclohexane-1-carboxylate + NAD(+) = 4-oxocyclohexane-1-carboxylate + NADH + H(+)

Direction not assertedBalancedRhea 17429

choline + A = betaine aldehyde + AH2

Left to rightBalancedRhea 17433

2-(2,4-dichloro-5-oxo-2,5-dihydrofuryl)acetate = (2E,4E)-2,4-dichloromuconate + H(+)

Direction not assertedBalancedRhea 17437

L-cysteine + 2-oxoglutarate = 2-oxo-3-sulfanylpropanoate + L-glutamate

ReversibleBalancedRhea 17441

H2 + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 reduced [2Fe-2S]-[ferredoxin] + 2 H(+)

Direction not assertedBalance undeterminableRhea 17445

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