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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

14,551–14,600 of 31,435, by identifier

N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA
Right to leftBalance undeterminableRhea 17017
(2-aminoethyl)phosphonate + pyruvate = phosphonoacetaldehyde + L-alanine
Direction not assertedBalancedRhea 17021
xylitol + NADP(+) = L-xylulose + NADPH + H(+)
Right to leftBalancedRhea 17025
(S)-allantoin + H2O = allantoate + H(+)
Direction not assertedBalancedRhea 17029
(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) = biphenyl-2,3-diol + NADH + H(+)
Direction not assertedBalancedRhea 17033
indole-3-ethanol + NADP(+) = indole-3-acetaldehyde + NADPH + H(+)
Direction not assertedBalancedRhea 17037
adenosine 5'-phosphosulfate + H2O = sulfate + AMP + 2 H(+)

Direction not assertedBalancedRhea 17041

3-demethylubiquinol-9 + S-adenosyl-L-methionine = ubiquinol-9 + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17049

D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate

ReversibleBalancedRhea 17053

a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]

Direction not assertedBalance undeterminableRhea 17057

phenol + NADPH + O2 + H(+) = catechol + NADP(+) + H2O

Direction not assertedBalancedRhea 17061

(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)

Direction not assertedBalancedRhea 17065

cortisol + acetyl-CoA = cortisol 21-acetate + CoA

Direction not assertedBalancedRhea 17073

N,N-dimethylglycine + O2 + H2O = sarcosine + formaldehyde + H2O2

Direction not assertedBalancedRhea 17077

(E)-isoeugenol + S-adenosyl-L-methionine = (E)-isomethyleugenol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17081

4-pyridoxate + A = 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2

Direction not assertedBalancedRhea 17085

2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate

Direction not assertedBalancedRhea 17089

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 17093

3-phenylpyruvate = enol-phenylpyruvate

Direction not assertedBalancedRhea 17097

an O-acyl-(R)-carnitine + H2O = (R)-carnitine + a fatty acid + H(+)

Direction not assertedBalance undeterminableRhea 17101

malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 17105

N-methylnicotinate + FMNH2 + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)

Direction not assertedBalancedRhea 17109

L-serine-phosphoethanolamine + H2O = phosphoethanolamine + L-serine + H(+)

Direction not assertedBalancedRhea 17113

methylamine + L-glutamate + ATP = N(5)-methyl-L-glutamine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 17117

carbamoyl phosphate + L-lysine = L-homocitrulline + phosphate + H(+)

Direction not assertedBalancedRhea 17121

N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine + H2O = N-(2-aminobutanoyl)glycine + 2-oxoglutarate

Direction not assertedBalancedRhea 17125

N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

Left to rightBalancedRhea 17129

L-seryl-[tyrosine-3-monooxygenase] + ATP = O-phospho-L-seryl-[tyrosine-3-monooxygenase] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 17133

prostaglandin H2 = thromboxane A2

Left to rightBalancedRhea 17137

oxaloacetate + glycine = glyoxylate + L-aspartate

Direction not assertedBalancedRhea 17141

2'-hydroxy-2,3-dihydrodaidzein + NADP(+) = 2'-hydroxydaidzein + NADPH + 2 H(+)

Direction not assertedBalancedRhea 17145

an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

ReversibleBalance undeterminableRhea 17149

CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O

Direction not assertedBalancedRhea 17153

creatine + ATP = N-phosphocreatine + ADP + H(+)

Left to rightBalancedRhea 17157

2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H(+)

Direction not assertedBalancedRhea 17161

alpha-D-galactose 1-phosphate + dTTP + H(+) = dTDP-D-galactose + diphosphate

Direction not assertedBalancedRhea 17165

alpha-D-galactosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-galactosamine 1-phosphate + CoA + H(+)

Direction not assertedBalancedRhea 17169

glutathionylspermidine + H2O = spermidine + glutathione

Direction not assertedBalancedRhea 17173

octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA

Left to rightBalancedRhea 17177

a long-chain fatty aldehyde + FMNH2 + O2 = a long-chain fatty acid + hnu + FMN + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 17181

IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)

Direction not assertedBalancedRhea 17185

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate

Left to rightBalance undeterminableRhea 17193

2 3-(4-hydroxyphenyl)pyruvate + O2 = 2 4-hydroxyphenylacetate + 2 CO2

Direction not assertedBalancedRhea 17197

2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H2O

Direction not assertedBalancedRhea 17201

quercetin 3-sulfate + 3'-phosphoadenylyl sulfate = quercetin 3,4'-bissulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 17205

1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O = 2-formylglutarate + NH4(+)

Direction not assertedBalancedRhea 17209

UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-mannosamine

Direction not assertedBalancedRhea 17213

dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O

Direction not assertedBalancedRhea 17221

1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] = 6-hydroxynicotinate + reduced 2[4Fe-4S]-[ferredoxin] + 2 H(+)

Direction not assertedBalance undeterminableRhea 17225

an aliphatic alcohol + acetyl-CoA = an acetyl ester + CoA

Direction not assertedBalance undeterminableRhea 17229

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