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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AssessmentsRegulatory determinations, transcribed
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Reference

Evidence

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

14,501–14,550 of 31,435, by identifier

L-kynurenine + H2O = anthranilate + L-alanine + H(+)
Direction not assertedBalancedRhea 16813
6-phospho-D-gluconate + NADP(+) = 6-phospho-2-dehydro-D-gluconate + NADPH + H(+)
Direction not assertedBalancedRhea 16817
6-phospho-D-gluconate + NAD(+) = 6-phospho-2-dehydro-D-gluconate + NADH + H(+)
Direction not assertedBalancedRhea 16821
uridine + ATP = UMP + ADP + H(+)
Direction not assertedBalancedRhea 16825
an aldehyde + O2 + H2O = a carboxylate + H2O2 + H(+)
Direction not assertedBalance undeterminableRhea 16829
2 glutathione + H2O2 = glutathione disulfide + 2 H2O
Left to rightBalancedRhea 16833
a 5'-acylphosphoadenosine + H2O = a carboxylate + AMP + 2 H(+)

? Direction not asserted

Balance undeterminable

Rhea 16837

precorrin-2 + S-adenosyl-L-methionine = precorrin-3A + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 16841

oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)

Direction not assertedBalancedRhea 16845

N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP

Direction not assertedBalancedRhea 16853

a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-methyl-2'-deoxycytidine in DNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 16857

(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = S-adenosyl-4-methylsulfanyl-2-oxobutanoate + (7R,8S)-7,8-diammoniononanoate

Direction not assertedBalancedRhea 16861

choloyl-CoA + propanoyl-CoA = 3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA + CoA

Right to leftBalancedRhea 16865

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

Left to rightBalancedRhea 16869

uridine(54) in tRNA + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADH + H(+) = 5-methyluridine(54) in tRNA + (6S)-5,6,7,8-tetrahydrofolate + NAD(+)

Direction not assertedBalancedRhea 16873

3-sulfino-L-alanine + H(+) = hypotaurine + CO2

Direction not assertedBalancedRhea 16877

thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H(+)

Direction not assertedBalancedRhea 16881

2 (4E,15E)-bilirubin IXalpha C8-beta-D-glucuronoside = bilirubin IXalpha bis-beta-D-glucuronoside + (4Z,15Z)-bilirubin IXalpha

Direction not assertedBalancedRhea 16885

6-acetamido-3-aminohexanoate + 2-oxoglutarate = 6-acetamido-3-oxohexanoate + L-glutamate

Direction not assertedBalancedRhea 16889

pyridine + S-adenosyl-L-methionine = N-methylpyridinium + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 16893

a 3beta-hydroxysteroid + a triacylglycerol = a 3beta-hydroxysteroid ester + a diacylglycerol

Direction not assertedBalance undeterminableRhea 16897

L-2,4-diaminobutanoate + acetyl-CoA = (2S)-4-acetamido-2-aminobutanoate + CoA + H(+)

Direction not assertedBalancedRhea 16901

a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = a 2,3-saturated aldehyde + sn-glycero-3-phosphoethanolamine

Direction not assertedBalance undeterminableRhea 16905

2 Fe(III)-[cytochrome c] + glycine + H2O = 2 Fe(II)-[cytochrome c] + glyoxylate + NH4(+) + 2 H(+)

Direction not assertedBalance undeterminableRhea 16909

a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)

Direction not assertedBalance undeterminableRhea 16913

2,6-dihydroxypyridine + NADH + O2 + H(+) = 2,3,6-trihydroxypyridine + NAD(+) + H2O

Direction not assertedBalancedRhea 16917

N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 16921

(E)-caffeoyl-CoA + S-adenosyl-L-methionine = (E)-feruloyl-CoA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 16925

2 benzoyl-CoA + L-ornithine = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H(+)

Direction not assertedBalancedRhea 16929

1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)

Direction not assertedBalancedRhea 16933

a 1-O-alkyl-sn-glycerol + ATP = a 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)

Left to rightBalance undeterminableRhea 16937

N-acetylindoxyl + O2 = N-acetylisatin + H2O

Direction not assertedBalancedRhea 16941

N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)

Direction not assertedBalance undeterminableRhea 16945

myo-inositol + NAD(+) = scyllo-inosose + NADH + H(+)

Direction not assertedBalancedRhea 16949

N(2)-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate

Direction not assertedBalancedRhea 16953

3',5'-cyclic GMP + H2O = GMP + H(+)

Left to rightBalancedRhea 16957

epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine

Direction not assertedBalancedRhea 16961

(2E)-geranyl diphosphate = beta-myrcene + diphosphate

Direction not assertedBalancedRhea 16965

dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose

Direction not assertedBalancedRhea 16969

2-hydroxypyridine + AH2 + O2 = 2,5-dihydroxypyridine + A + H2O

Direction not assertedBalancedRhea 16973

coenzyme M + acetoacetate + NADP(+) = 2-oxopropyl-coenzyme M + CO2 + NADPH

Direction not assertedBalancedRhea 16977

3-oxoadipate + NAD(+) = maleylacetate + NADH + H(+)

Direction not assertedBalancedRhea 16981

3-oxoadipate + NADP(+) = maleylacetate + NADPH + H(+)

Direction not assertedBalancedRhea 16985

1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate

Left to rightBalancedRhea 16989

S-disulfanyl-L-cysteinyl-[SoxY protein] + 6 Fe(III)-[cytochrome c] + 3 H2O = S-sulfosulfanyl-L-cysteinyl-[SoxY protein] + 6 Fe(II)-[cytochrome c] + 7 H(+)

Direction not assertedBalance undeterminableRhea 16993

5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol + 3'-phosphoadenylyl sulfate = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 16997

amidinoproclavaminate + H2O = proclavaminate + urea

Direction not assertedBalancedRhea 17001

D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + H(+)

Direction not assertedBalancedRhea 17005

2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 17009

phosphoenolpyruvate + H(+) = 3-phosphonopyruvate

Direction not assertedBalancedRhea 17013

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