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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Interactions
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Reactions
Reach

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

14,251–14,300 of 31,435, by identifier

L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate
Direction not assertedBalancedRhea 15781
L-xylose + NADP(+) = L-xylono-1,4-lactone + NADPH + H(+)
Direction not assertedBalancedRhea 15789
(4Z,15Z)-bilirubin IXalpha + NADP(+) = biliverdin IXalpha + NADPH + H(+)
Right to leftBalancedRhea 15793
(4Z,15Z)-bilirubin IXalpha + NAD(+) = biliverdin IXalpha + NADH + H(+)
Right to leftBalancedRhea 15797
a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
Left to rightBalance undeterminableRhea 15801
(7R,8S)-7,8-diammoniononanoate + CO2 + ATP = (4R,5S)-dethiobiotin + ADP + phosphate + 3 H(+)
Direction not assertedBalancedRhea 15805
(2E)-geranyl diphosphate + H2O = (R)-linalool + diphosphate

Direction not assertedBalancedRhea 15809

1H-imidazole + acetyl-CoA = N-acetylimidazole + CoA

Direction not assertedBalancedRhea 15813

pyridoxamine 5'-phosphate + O2 + H2O = pyridoxal 5'-phosphate + H2O2 + NH4(+)

Left to rightBalancedRhea 15817

glycine + 2 A = hydrogen cyanide + 2 AH2 + CO2

Direction not assertedBalancedRhea 15821

AZD1979 + H2O = AZD1979 oxetane hydrolysis product + H(+)

Direction not assertedBalancedRhea 15825

a 16alpha-hydroxysteroid = a 16beta-hydroxysteroid

Direction not assertedBalance undeterminableRhea 15829

(S)-4-hydroxymandelate + O2 + H(+) = 4-hydroxybenzaldehyde + H2O2 + CO2

Direction not assertedBalancedRhea 15833

methylamine + L-glutamate = N-methyl-L-glutamate + NH4(+)

Direction not assertedBalancedRhea 15837

D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH + H(+)

Left to rightBalancedRhea 15841

4-O-{[(2R)-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP-alpha-D-glucose = 4-O-{[(2R)-2-alpha-D-glucosyl-1-glycerylphospho](n)-(2R)-1-glycerylphospho}-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl undecaprenyl diphosphate + n UDP + n H(+)

Direction not assertedBalance undeterminableRhea 15845

L-ascorbate + 2 Fe(III)-[cytochrome c] = L-dehydroascorbate + 2 Fe(II)-[cytochrome c] + 2 H(+)

Direction not assertedBalance undeterminableRhea 15849

(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NAD(+) = 17alpha-hydroxyprogesterone + NADH + H(+)

Direction not assertedBalancedRhea 15853

(17R,20S)-17,20-dihydroxypregn-4-en-3-one + NADP(+) = 17alpha-hydroxyprogesterone + NADPH + H(+)

Right to leftBalancedRhea 15857

3-ADP-2-phosphoglycerate + H2O = 3-ADP-glycerate + phosphate

Direction not assertedBalancedRhea 15861

tryptamine + AH2 + O2 = 4-hydroxytryptamine + A + H2O

Direction not assertedBalancedRhea 15865

D-alanine + 2-oxoglutarate = D-glutamate + pyruvate

Direction not assertedBalancedRhea 15869

an NDP-alpha-D-glucose + [(1->4)-alpha-D-glucosyl](n) = [(1->4)-alpha-D-glucosyl](n+1) + a ribonucleoside 5'-diphosphate + H(+)

Direction not assertedBalance undeterminableRhea 15873

pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate

Direction not assertedBalancedRhea 15877

L-seryl-[Fas-activated protein] + ATP = O-phospho-L-seryl-[Fas-activated protein] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 15881

propane-1,2-diol + NADP(+) = (S)-lactaldehyde + NADPH + H(+)

Direction not assertedBalancedRhea 15885

L-glutamine + H2O = L-glutamate + NH4(+)

Direction not assertedBalancedRhea 15889

Co-sirohydrochlorin + 2 H(+) = sirohydrochlorin + Co(2+)

Direction not assertedBalancedRhea 15893

4-acetamidobutanoate + H2O = 4-aminobutanoate + acetate

Direction not assertedBalancedRhea 15897

(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate

ReversibleBalancedRhea 15901

3-hydroxycyclohexanone + A = cyclohexane-1,3-dione + AH2

Direction not assertedBalancedRhea 15905

taurine + 2-oxoglutarate + O2 = aminoacetaldehyde + sulfite + succinate + CO2 + H(+)

Direction not assertedBalancedRhea 15909

thiamine phosphate + ATP = thiamine diphosphate + ADP

Direction not assertedBalancedRhea 15913

an aldopyranose + NAD(+) = aldono-1,5-lactone + NADH + H(+)

Direction not assertedBalance undeterminableRhea 15917

2 a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol = a 1,2-diacyl-3-O-[beta-D-galactosyl-(1->6)-beta-D-galactosyl]-sn-glycerol + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 15921

dihydrobunolol + NADP(+) = bunolol + NADPH + H(+)

Direction not assertedBalancedRhea 15925

methylenediurea + 2 H2O + 2 H(+) = N-(hydroxymethyl)urea + 2 NH4(+) + CO2

Direction not assertedBalancedRhea 15929

(S)-propane-1,2-diol + NAD(+) = (S)-lactaldehyde + NADH + H(+)

Direction not assertedBalancedRhea 15933

a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)

Right to leftBalance undeterminableRhea 15937

N(2)-acetyl-L-ornithine + H2O = L-ornithine + acetate

Direction not assertedBalancedRhea 15941

aldehydo-D-glucose 6-phosphate + L-lysyl-[protein] = N(6)-(6-O-phospho-D-fructosyl)-L-lysyl-[protein] + H2O

Direction not assertedBalance undeterminableRhea 15945

(R)-2-hydroxyoctadecanoate + NAD(+) = 2-oxooctadecanoate + NADH + H(+)

Direction not assertedBalancedRhea 15949

agmatine + ATP = N(4)-phosphoagmatine + ADP + 2 H(+)

Direction not assertedBalancedRhea 15953

D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O

Direction not assertedBalancedRhea 15957

4-hydroxymandelonitrile + UDP-alpha-D-glucose = taxiphyllin + UDP + H(+)

Direction not assertedBalancedRhea 15961

a 1-O-alkyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-O-alkyl-sn-glycero-3-phosphate + ethanolamine + H(+)

Direction not assertedBalance undeterminableRhea 15965

methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

Direction not assertedBalancedRhea 15969

estrone + 3'-phosphoadenylyl sulfate = estrone 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalancedRhea 15973

(S)-4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrogen cyanide

Direction not assertedBalancedRhea 15977

S-adenosyl-L-methionine + H(+) = S-adenosyl 3-(methylsulfanyl)propylamine + CO2

Direction not assertedBalancedRhea 15981

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