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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

14,201–14,250 of 31,435, by identifier

N-acetylserotonin + S-adenosyl-L-methionine = melatonin + S-adenosyl-L-homocysteine + H(+)
Right to leftBalancedRhea 15573
uridine + H2O = D-ribose + uracil
Direction not assertedBalancedRhea 15577
biochanin A 7-O-beta-D-glucoside + malonyl-CoA = biochanin A 7-O-beta-D-glucoside 6''-O-malonate + CoA
Direction not assertedBalancedRhea 15581
15-cis-phytoene + 4 A = all-trans-lycopene + 4 AH2
Direction not assertedBalancedRhea 15585
D-4-hydroxyphenylglycine + 2-oxoglutarate = 4-hydroxyphenylglyoxylate + L-glutamate
Direction not assertedBalancedRhea 15589
amicoumacin A 2-phosphate + H2O = amicoumacin A + phosphate
Direction not assertedBalancedRhea 15593
a Fe(III)-siderophore(out) + ATP + H2O = a Fe(III)-siderophore(in) + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableTransportRhea 15597

(E)-cinnamoyl-CoA + (R)-3-phenyllactate = (R)-3-phenyllactoyl-CoA + (E)-cinnamate

Direction not assertedBalancedRhea 15601

L-serine O-sulfate + H2O = sulfate + pyruvate + NH4(+) + H(+)

Direction not assertedBalancedRhea 15605

D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)

Left to rightBalancedRhea 15609

precorrin-2 + NAD(+) = sirohydrochlorin + NADH + 2 H(+)

Direction not assertedBalancedRhea 15613

Fe(3+) + Fe(II)-[cytochrome c] = Fe(2+) + Fe(III)-[cytochrome c]

Direction not assertedBalance undeterminableRhea 15617

an N-acetyl-alpha-D-galactosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + UDP + H(+)

Direction not assertedBalance undeterminableRhea 15621

Co-precorrin-6B + NAD(+) = Co-precorrin-6A + NADH + H(+)

Direction not assertedBalancedRhea 15625

a steroid + 2 reduced [adrenodoxin] + O2 + 2 H(+) = an 11beta-hydroxysteroid + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 15629

3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde + H(+)

Direction not assertedBalancedRhea 15633

[alginate](n) + GDP-alpha-D-mannuronate = [alginate](n+1) + GDP + H(+)

Direction not assertedBalance undeterminableRhea 15637

oxaloacetate + H(+) = pyruvate + CO2

Left to rightBalancedRhea 15641

N2 + 4 reduced [flavodoxin] + 16 ATP + 16 H2O = 4 oxidized [flavodoxin] + H2 + 2 NH4(+) + 16 ADP + 16 phosphate + 18 H(+)

Direction not assertedBalance undeterminableRhea 15645

carbamate + 2 H(+) = NH4(+) + CO2

Direction not assertedBalancedRhea 15649

beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + H(+)

Left to rightBalancedRhea 15653

1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO2 + NADH

Direction not assertedBalancedRhea 15657

an anthocyanidin 3,5-di-O-beta-D-glucoside + (E)-4-coumaroyl-CoA = an anthocyanidin 3-O-beta-D-glucoside 5-O-beta-D-[(6-O-(E)-4-coumaroyl)glucoside] + CoA

Direction not assertedBalance undeterminableRhea 15661

aldehydo-D-glucose + L-lysyl-[protein] = N(6)-(D-fructosyl)-L-lysyl-[protein] + H2O

Direction not assertedBalance undeterminableRhea 15665

a 5'-end dephospho-2'-deoxyribonucleoside-DNA + ATP = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + ADP + H(+)

Direction not assertedBalance undeterminableRhea 15669

acetoacetyl-CoA + H2O = acetoacetate + CoA + H(+)

Left to rightBalancedRhea 15673

5-aminopentanamide + H2O = 5-aminopentanoate + NH4(+)

Direction not assertedBalancedRhea 15677

2-hydroxy-5-carboxymethylmuconate semialdehyde + NAD(+) + H2O = (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate + NADH + 2 H(+)

Direction not assertedBalancedRhea 15681

L-2,4-diaminobutanoate + H(+) = propane-1,3-diamine + CO2

Direction not assertedBalancedRhea 15689

(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + AH2 = (R)-2-hydroxy-(9Z,12Z,15Z)-octadecatrienoate + A + H2O

Direction not assertedBalancedRhea 15693

(2S)-liquiritigenin + reduced [NADPH--hemoprotein reductase] + O2 = licodione + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 15697

phenylacetyl-CoA + 2 a ubiquinone + H2O = phenylglyoxylyl-CoA + 2 a ubiquinol

Direction not assertedBalance undeterminableRhea 15705

kaempferol + UDP-alpha-D-galactose = kaempferol 3-O-beta-D-galactoside + UDP + H(+)

Direction not assertedBalancedRhea 15709

a beta-D-galactoside + acetyl-CoA = a 6-acetyl-beta-D-galactoside + CoA

Direction not assertedBalance undeterminableRhea 15713

daunorubicin + NADPH + O2 + H(+) = doxorubicin + NADP(+) + H2O

Direction not assertedBalancedRhea 15717

glycine + NAD(+) + H2O = glyoxylate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 15721

1,5-anhydro-D-fructose = ascopyrone M + H2O

Direction not assertedBalancedRhea 15725

D-mannonate + NAD(+) = keto-D-fructuronate + NADH + H(+)

Direction not assertedBalancedRhea 15729

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + A + H2O = (24R,25R)-3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oyl-CoA + AH2

Direction not assertedBalancedRhea 15733

cyclopentanone + NADPH + O2 + H(+) = 5-valerolactone + NADP(+) + H2O

Direction not assertedBalancedRhea 15737

2,5-dichlorocyclohexa-2,5-dien-1,4-diol + NAD(+) = 2,5-dichlorohydroquinone + NADH + H(+)

Direction not assertedBalancedRhea 15741

[(2->1)-beta-D-fructosyl](n) + sucrose = [(2->1)-beta-D-fructosyl](n+1) + D-glucose

Direction not assertedBalance undeterminableRhea 15745

(S)-mandelate + A = phenylglyoxylate + AH2

Direction not assertedBalancedRhea 15749

IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)

Direction not assertedBalancedRhea 15753

L-homoserine + NAD(+) = L-aspartate 4-semialdehyde + NADH + H(+)

Direction not assertedBalancedRhea 15757

L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)

Direction not assertedBalancedRhea 15761

adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)

Direction not assertedBalancedRhea 15765

adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)

Direction not assertedBalancedRhea 15769

dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)

Direction not assertedBalancedRhea 15773

1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + H2O = 1-guanidino-1-deoxy-scyllo-inositol + phosphate

Direction not assertedBalancedRhea 15777

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