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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

14,001–14,050 of 31,435, by identifier

beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate
ReversibleBalancedRhea 14729
Ag(+)(in) + ATP + H2O = Ag(+)(out) + ADP + phosphate + H(+)
Direction not assertedBalancedTransportRhea 14733
CTP = 3',5'-cyclic CMP + diphosphate
Direction not assertedBalancedRhea 14737
4-methylene-L-glutamine + H2O = 4-methylene-L-glutamate + NH4(+)
Direction not assertedBalancedRhea 14741
1-hydroxy-2-naphthoate + O2 = (3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H(+)
Direction not assertedBalancedRhea 14749
17alpha-hydroxyprogesterone + reduced [NADPH--hemoprotein reductase] + O2 = androst-4-ene-3,17-dione + acetate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)
Left to rightBalance undeterminableRhea 14753
L-galactono-1,4-lactone + 2 Fe(III)-[cytochrome c] = L-ascorbate + 2 Fe(II)-[cytochrome c] + 3 H(+)

Direction not assertedBalance undeterminableRhea 14757

L-serine + hexadecanoyl-CoA + H(+) = 3-oxosphinganine + CO2 + CoA

Left to rightBalancedRhea 14761

coelenterazine h + O2 = excited coelenteramide h monoanion + hnu + CO2 + H(+)

Direction not assertedBalance undeterminableRhea 14765

(S)-nicotine + A + H2O = (S)-6-hydroxynicotine + AH2

Direction not assertedBalancedRhea 14769

palmatine + S-adenosyl-L-methionine + 2 NADPH = corydaline + S-adenosyl-L-homocysteine + 2 NADP(+)

Direction not assertedBalancedRhea 14773

AMP + H2O + H(+) = IMP + NH4(+)

Left to rightBalancedRhea 14777

heptanedioate + ATP + CoA = 6-carboxyhexanoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 14781

RNA(n) + UTP = RNA(n)-3'-uridine ribonucleotide + diphosphate

Direction not assertedBalance undeterminableRhea 14785

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)

Left to rightBalance undeterminableRhea 14789

2-hydroxyadipate + NAD(+) = 2-oxoadipate + NADH + H(+)

Direction not assertedBalancedRhea 14793

2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + H(+)

Direction not assertedBalancedRhea 14797

(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP

ReversibleBalancedRhea 14801

D-allose + ATP = D-allose 6-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 14805

phenol + S-adenosyl-L-methionine = anisole + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 14809

L-2-aminohexano-6-lactam = D-2-aminohexano-6-lactam

Direction not assertedBalancedRhea 14813

4-maleylacetoacetate = 4-fumarylacetoacetate

Direction not assertedBalancedRhea 14817

beta-L-arabinopyranose = L-ribulose

Direction not assertedBalancedRhea 14821

(1R,5S)-carveol + NAD(+) = (S)-carvone + NADH + H(+)

Direction not assertedBalancedRhea 14825

O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate

Direction not assertedBalancedRhea 14829

(R)-mevalonate + 2 NAD(+) + CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H(+)

Direction not assertedBalancedRhea 14833

glyoxylate + O2 + H2O = oxalate + H2O2 + H(+)

Left to rightBalancedRhea 14837

(2E,6E,10E)-geranylgeranyl diphosphate = ent-copalyl diphosphate

Direction not assertedBalancedRhea 14841

L-aspartate 4-semialdehyde + pyruvate = (S)-2,3-dihydrodipicolinate + 2 H2O + H(+)

Direction not assertedBalancedRhea 14845

N-amidino-L-aspartate + H2O = urea + L-aspartate

Direction not assertedBalancedRhea 14849

4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl-CoA + chloride + H(+)

Direction not assertedBalancedRhea 14853

(indol-3-yl)acetate + L-lysine + ATP = N(6)-[(indole-3-yl)acetyl]-L-lysine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 14857

(S)-dihydroorotate + NADP(+) = orotate + NADPH + H(+)

Direction not assertedBalancedRhea 14861

tyramine + S-adenosyl-L-methionine = N-methyltyramine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 14865

an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + acetate

Direction not assertedBalance undeterminableRhea 14869

indole-3-ethanol + NAD(+) = indole-3-acetaldehyde + NADH + H(+)

Direction not assertedBalancedRhea 14873

L-glutamate + ATP = L-glutamyl 5-phosphate + ADP

Direction not assertedBalancedRhea 14877

3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) = asparagusate + NADH + H(+)

Direction not assertedBalancedRhea 14881

N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + H2O = ADP-D-ribose + L-arginyl-[protein]

Left to rightBalance undeterminableRhea 14885

(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate

Direction not assertedBalancedRhea 14889

D-ornithine = (2R,4S)-2,4-diaminopentanoate

Direction not assertedBalancedRhea 14893

(2E,6E,10E)-geranylgeranyl diphosphate = casbene + diphosphate

Direction not assertedBalancedRhea 14901

5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O

Right to leftBalancedRhea 14905

L-gulonate + NADP(+) = aldehydo-D-glucuronate + NADPH + H(+)

Direction not assertedBalancedRhea 14909

thymidine + AMP = dTMP + adenosine

Direction not assertedBalancedRhea 14913

obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)

Direction not assertedBalance undeterminableRhea 14917

(indol-3-yl)acetate + UDP-alpha-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP

Direction not assertedBalancedRhea 14921

D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 14925

testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+)

Left to rightBalancedRhea 14929

N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] + H2O = N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate

Direction not assertedBalance undeterminableRhea 14933

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