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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Reactions
Reach

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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

13,951–14,000 of 31,435, by identifier

mugineate + 2-oxoglutarate + O2 = 3-epihydroxymugineate + succinate + CO2 + H(+)
Direction not assertedBalancedRhea 14509
L-aspartyl-tRNA(Asn) + L-glutamine + ATP + H2O = L-asparaginyl-tRNA(Asn) + L-glutamate + ADP + phosphate + 2 H(+)
Direction not assertedBalancedRhea 14513
(E)-feruloyl-CoA + H2O = 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA
Direction not assertedBalancedRhea 14517
(2E)-geraniol + NADP(+) = (2E)-geranial + NADPH + H(+)
Direction not assertedBalancedRhea 14521
beta-cyclopiazonate + A = alpha-cyclopiazonate + AH2
Direction not assertedBalancedRhea 14525
D-ribose 5-phosphate + ADP + H(+) = ADP-D-ribose + phosphate
Direction not assertedBalancedRhea 14529
creatinine + H2O = creatine

Direction not assertedBalancedRhea 14533

1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + H2O + H(+) = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(2-hydroxyethyl)-2-methylpyridinium + NH4(+)

Direction not assertedBalancedRhea 14537

choloyl-CoA + H2O = cholate + CoA + H(+)

Left to rightBalancedRhea 14541

nicotinamide + H2O = nicotinate + NH4(+)

Direction not assertedBalancedRhea 14545

(2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H2O = 2-oxopent-4-enoate + formate + H(+)

Direction not assertedBalancedRhea 14549

(7R)-7-(5-carboxy-5-oxopentanamido)deacetylcephalosporanate + D-glutamate = cephalosporin C + 2-oxoglutarate

Direction not assertedBalancedRhea 14553

raucaffricine + H2O = vomilenine + D-glucose

Direction not assertedBalancedRhea 14557

piperidine + (E,E)-piperoyl-CoA = piperine + CoA + H(+)

Direction not assertedBalancedRhea 14561

(11Z)-hexadecenoyl-[ACP] + malonyl-[ACP] + H(+) = 3-oxo-(13Z)-octadecenoyl-[ACP] + holo-[ACP] + CO2

Direction not assertedBalance undeterminableRhea 14565

propane-1,2-diol = propanal + H2O

Direction not assertedBalancedRhea 14569

D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O

Direction not assertedBalancedRhea 14573

2 monodehydro-L-ascorbate radical + NADH + H(+) = 2 L-ascorbate + NAD(+)

Direction not assertedBalancedRhea 14581

gibberellin A12 + 4 reduced [2Fe-2S]-[ferredoxin] + 3 O2 + 5 H(+) = gibberellin A9 + 4 oxidized [2Fe-2S]-[ferredoxin] + CO2 + 4 H2O

Direction not assertedBalance undeterminableRhea 14585

luteolin + S-adenosyl-L-methionine = chrysoeriol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 14589

a CDP-1,2-diacyl-sn-glycerol + choline = a 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)

Direction not assertedBalance undeterminableRhea 14597

L-lysine + O2 = 5-aminopentanamide + CO2 + H2O

Direction not assertedBalancedRhea 14601

GDP-alpha-D-glucose + D-glucose 6-phosphate = alpha,alpha-trehalose 6-phosphate + GDP + H(+)

Direction not assertedBalancedRhea 14605

D-sorbitol + NADP(+) = keto-L-sorbose + NADPH + H(+)

Direction not assertedBalancedRhea 14609

taurine(out) + ATP + H2O = taurine(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 14613

glutathione + NADP(+) + CoA = CoA-glutathione + NADPH + H(+)

Direction not assertedBalancedRhea 14617

(S)-2,3-epoxysqualene = lanosterol

Left to rightBalancedRhea 14621

[(1->6)-alpha-D-glucosyl](n+1) + [(1->4)-alpha-D-glucosyl](n) = [(1->6)-alpha-D-glucosyl](n) + [(1->4)-alpha-D-glucosyl](n+1)

Direction not assertedBalance undeterminableRhea 14625

N-acetyl-L-glutamate + ATP = N-acetyl-L-glutamyl 5-phosphate + ADP

Direction not assertedBalancedRhea 14629

Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 14633

a thiol + 3'-phosphoadenylyl sulfate = S-alkyl thiosulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalance undeterminableRhea 14637

cyanurate + H2O = biuret + CO2

Direction not assertedBalancedRhea 14641

dTDP-beta-L-mycarose + demethyllactenocin = demethylmacrocin + dTDP + H(+)

Direction not assertedBalancedRhea 14649

a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate + H(+)

Left to rightBalance undeterminableRhea 14653

aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate

ReversibleBalancedRhea 14657

guanine + H2O + H(+) = xanthine + NH4(+)

Left to rightBalancedRhea 14665

D-glyceraldehyde 3-phosphate + NADP(+) + H2O = (2R)-3-phosphoglycerate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 14669

a polar amino acid(out) + ATP + H2O = a polar amino acid(in) + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableTransportRhea 14673

2 2-aminophenol + A + O2 = 2-aminophenoxazin-3-one + AH2 + 2 H2O

Direction not assertedBalancedRhea 14681

a primary alcohol + A = an aldehyde + AH2

Direction not assertedBalance undeterminableRhea 14685

4-chlorophenylacetate + NADH + O2 = 3,4-dihydroxyphenylacetate + chloride + NAD(+)

Direction not assertedBalancedRhea 14689

a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-phospho-di-trans,poly-cis-dolichol + UDP

Direction not assertedBalance undeterminableRhea 14693

(2E,6E)-farnesol + NADP(+) = (2E,6E)-farnesal + NADPH + H(+)

Direction not assertedBalancedRhea 14697

NAD(+) + 2 CoA = CoA-disulfide + NADH + H(+)

Direction not assertedBalancedRhea 14701

NADP(+) + 2 CoA = CoA-disulfide + NADPH + H(+)

Direction not assertedBalancedRhea 14705

a 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid

Direction not assertedBalance undeterminableRhea 14709

keto-L-sorbose + A = 5-dehydro-D-fructose + AH2

Direction not assertedBalancedRhea 14713

D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate

Direction not assertedBalancedRhea 14717

zeatin + UDP-alpha-D-xylose = O-beta-D-xylosylzeatin + UDP + H(+)

Direction not assertedBalancedRhea 14721

2 cob(II)inamide + reduced [electron-transfer flavoprotein] + 2 ATP = 2 adenosylcob(III)inamide + 2 triphosphate + oxidized [electron-transfer flavoprotein] + 3 H(+)

Direction not assertedBalance undeterminableRhea 14725

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