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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

13,901–13,950 of 31,435, by identifier

a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H2O = D-galactose + an N-acylsphing-4-enine
Left to rightBalance undeterminableRhea 14297
4-pyridoxolactone + H2O = 4-pyridoxate + H(+)
Direction not assertedBalancedRhea 14301
tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate
Left to rightBalancedRhea 14305
2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 14313
morphine + NAD(+) = morphinone + NADH + H(+)
Direction not assertedBalancedRhea 14317
morphine + NADP(+) = morphinone + NADPH + H(+)
Direction not assertedBalancedRhea 14321
7,8-dihydroxycoumarin + UDP-alpha-D-glucose = daphnin + UDP + H(+)

Direction not assertedBalancedRhea 14325

O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate

Right to leftBalancedRhea 14329

a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol = 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 14333

UDP-N-acetyl-alpha-D-galactosamine 4-sulfate + 3'-phosphoadenylyl sulfate = UDP-N-acetyl-alpha-D-galactosamine 4,6-bissulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 14337

glyoxylate + 2-oxoglutarate + H(+) = 2-hydroxy-3-oxoadipate + CO2

Direction not assertedBalancedRhea 14341

L-tyrosine + H(+) = tyramine + CO2

Direction not assertedBalancedRhea 14345

an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + UDP + H(+)

Left to rightBalance undeterminableRhea 14349

3-dehydro-L-gulonate 6-phosphate + H(+) = L-xylulose 5-phosphate + CO2

Direction not assertedBalancedRhea 14353

riboflavin + ATP = FMN + ADP + H(+)

Left to rightBalancedRhea 14357

N-carbamoyl-L-aspartate + H2O + 2 H(+) = L-aspartate + NH4(+) + CO2

Direction not assertedBalancedRhea 14365

2-phosphoglycolate + H2O = glycolate + phosphate

Direction not assertedBalancedRhea 14369

5beta-cholestane-3alpha,7alpha,12alpha-triol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 14373

(3R)-3-hydroxy-L-aspartate = glyoxylate + glycine

Direction not assertedBalancedRhea 14377

4-guanidinobutanal + NAD(+) + H2O = 4-guanidinobutanoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 14381

a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 14385

a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)

Direction not assertedBalance undeterminableRhea 14389

N-terminal L-alanyl-[cypemycin] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-alanyl-[cypemycin] + 2 S-adenosyl-L-homocysteine + 3 H(+)

Direction not assertedBalance undeterminableRhea 14393

(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H(+) = (4Z)-2-oxohept-4-enedioate + CO2

Direction not assertedBalancedRhea 14397

chlordecone alcohol + NADP(+) = chlordecone + NADPH + H(+)

Direction not assertedBalancedRhea 14401

D-glucose + NADP(+) = D-glucono-1,5-lactone + NADPH + H(+)

Left to rightBalancedRhea 14405

cysteamine + O2 = hypotaurine + H(+)

Left to rightBalancedRhea 14409

biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+)

Direction not assertedBalancedRhea 14413

acetyl phosphate + L-lysine = N(6)-acetyl-L-lysine + phosphate + H(+)

Direction not assertedBalancedRhea 14417

N(2)-benzoyl-D-arginine-4-nitroanilide + H2O = N(2)-benzoyl-D-arginine + 4-nitroaniline + H(+)

Direction not assertedBalancedRhea 14421

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)

Left to rightBalance undeterminableRhea 14425

a [oligopeptide](in) + ATP + H2O = a [oligopeptide](out) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 14429

a tRNA precursor + 2 CTP + ATP = a tRNA with a 3' CCA end + 3 diphosphate

Left to rightBalance undeterminableRhea 14433

L-lysine + O2 + H2O = 6-amino-2-oxohexanoate + H2O2 + NH4(+)

Direction not assertedBalancedRhea 14437

gentamicin C + acetyl-CoA = N(3)-acetylgentamycin C + CoA + H(+)

Direction not assertedBalance undeterminableRhea 14441

a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)

Left to rightBalance undeterminableRhea 14445

chlorophyllide a + NADP(+) = 3,8-divinyl chlorophyllide a + NADPH + H(+)

Direction not assertedBalancedRhea 14449

pentanoyl-CoA + glyoxylate + H2O = 3-propylmalate + CoA + H(+)

Direction not assertedBalancedRhea 14457

(25S)-5beta-spirostan-3beta-ol + UDP-alpha-D-glucose = (25S)-5beta-spirostan-3beta-yl beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 14461

L-histidinol phosphate + H2O = L-histidinol + phosphate

Direction not assertedBalancedRhea 14465

2-aminomuconate 6-semialdehyde + NAD(+) + H2O = (2Z,4E)-2-aminomuconate + NADH + 2 H(+)

Direction not assertedBalancedRhea 14469

a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)

Right to leftBalance undeterminableRhea 14473

a medium-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a medium-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 14477

2-hydroxy-5-methylsulfanyl-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate

Direction not assertedBalancedRhea 14481

(2E,6E)-farnesyl diphosphate + H2O = 10-epi-juneol + diphosphate

Direction not assertedBalancedRhea 14485

a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 2'-phosphate + H(+)

Direction not assertedBalance undeterminableRhea 14489

N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + H2O = L-arginyl-[dinitrogen reductase] + ADP-D-ribose

Direction not assertedBalance undeterminableRhea 14493

pyridoxine + A = isopyridoxal + AH2

Direction not assertedBalancedRhea 14497

L-homocysteine + H2O = 2-oxobutanoate + hydrogen sulfide + NH4(+) + H(+)

Left to rightBalancedRhea 14501

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

Direction not assertedBalancedRhea 14505

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